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• W2103509958 abstract "We introduce another view of sequence evolution. Contrary to other approaches, we model the substitution process in two steps. First we assume (arbitrary) scaled branch lengths on a given phylogenetic tree. Second we allocate a Poisson distributed number of substitutions on the branches. The probability to place a mutation on a branch is proportional to its relative branch length. More importantly, the action of a single mutation on an alignment column is described by a doubly stochastic matrix, the so-called one-step mutation matrix. This matrix leads to analytical formulae for the posterior probability distribution of the number of substitutions for an alignment column." @default.
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• W2103509958 date "2008-10-07" @default.
• W2103509958 modified "2023-10-05" @default.
• W2103509958 title "The impact of single substitutions on multiple sequence alignments" @default.
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• W2103509958 doi "https://doi.org/10.1098/rstb.2008.0140" @default.
• W2103509958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2607407" @default.
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