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• W2103518970 abstract "Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR). PCSK9 and LDLR are also expressed in insulin-producing pancreatic islet β cells, possibly affecting the function of these cells. Here we show that, compared to control mice, PCSK9-null male mice over 4 months of age carried more LDLR and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose-intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. Collectively, these observations suggest that PCSK9 may be necessary for the normal function of pancreatic islets." @default.
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• W2103518970 date "2009-12-16" @default.
• W2103518970 modified "2023-10-18" @default.
• W2103518970 title "PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities" @default.
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• W2103518970 doi "https://doi.org/10.1016/j.febslet.2009.12.018" @default.
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