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- W2103520912 abstract "The function of the brainstem Hap1-Ahi1 complex in the regulation of feeding behavior was investigated. When mice were fasted or treated with 2-deoxy-D-glucose (2-DG), Hap1-Ahi1 was significantly upregulated. By using streptozotocin (STZ) to decrease the circulating insulin in mice, Hap1-Ahi1 was significantly increased. Furthermore, intra-brain injection of insulin decreased the expression of Hap1-Ahi1 in the brainstem. Moreover, when we knocked down the expression of brainstem Hap1 by RNAi, the mice showed decreased food intake and lower body weights. Collectively, our results indicate that the Hap1-Ahi1 complex in the brainstem works as a sensor for insulin signals in feeding control." @default.
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- W2103520912 date "2010-12-10" @default.
- W2103520912 modified "2023-09-23" @default.
- W2103520912 title "Brainstem Hap1-Ahi1 is involved in insulin-mediated feeding control" @default.
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- W2103520912 doi "https://doi.org/10.1016/j.febslet.2010.11.059" @default.
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