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- W2103528343 abstract "We report the first demonstration of Thy-1+, Lyt-2-, L3T4- MHC-specific CTL clones derived from the Lyt-2-, L3T4- subset of lymph node cells of C3H-gld/gld mice. These clones express alpha/beta heterodimeric TCRs on the cell surface and specifically recognize class I molecules on target cells. Lyt-2 and L3T4 molecules are therefore not essential for the induction, recognition, and killing of antigen-specific CTL. In addition, these studies suggest that antigen specificity development for class I structures may occur before Lyt-2 gene activation in the differentiation of T cells." @default.
- W2103528343 created "2016-06-24" @default.
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- W2103528343 date "1987-10-01" @default.
- W2103528343 modified "2023-09-27" @default.
- W2103528343 title "Characterization of Lyt-2-, L3T4- class I-specific cytolytic clones in C3H-gld/gld mice. Implications for functions of accessory molecules and programmed development." @default.
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- W2103528343 doi "https://doi.org/10.1084/jem.166.4.1026" @default.
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