FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103548416> ?p ?o ?g. }

• W2103548416 endingPage "5559" @default.
• W2103548416 startingPage "5552" @default.
• W2103548416 abstract "Abstract Purpose: The main function of erythropoietin (EPO) is to stimulate erythropoiesis. EPO receptors (EPOR) are expressed in other cell types, including tumor cells, suggesting that the EPO/EPOR pathway governs additional cellular processes besides erythropoiesis. Recombinant EPO (rhEPO) is frequently given to anemic cancer patients, although data on clinical outcome are conflicting. In an attempt to understand these clinical data, we analyzed EPO and EPOR expression in breast cancer and evaluated EPOR as a putative prognostic and predictive marker in breast cancer patients treated with tamoxifen. Experimental Design: EPO mRNA/protein and EPOR mRNA were quantified by PCR and ELISA, respectively. Tissue microarrays containing 500 breast tumors from premenopausal women randomized to tamoxifen or no adjuvant treatment were evaluated for EPOR expression by immunohistochemistry. Predictive and prognostic information was evaluated using Kaplan-Meier curves and log-rank tests to estimate recurrence-free survival (RFS). Results: EPO and EPOR were expressed in cultured cells, and breast tumor specimens expressed EPOR at varying levels. Tamoxifen treatment significantly increased RFS in patients with estrogen receptor–positive/progesterone receptor–positive (ER+/PR+) tumors with low EPOR expression (P = 0.001) but had no effect on RFS in patients with tumors with high EPOR expression (P = 0.98). In the untreated cohort, RFS was significantly improved for patients with ER+ tumors with high EPOR expression. Conclusion: EPOR is abundantly expressed in breast cancer specimens. The fact that high expression of EPOR is related to an impaired tamoxifen response in ER+/PR+ tumors and to improved survival in untreated patients suggests that EPOR expression in breast cancer affects tumor behavior. (Clin Cancer Res 2009;15(17):5552–9)" @default.
• W2103548416 created "2016-06-24" @default.
• W2103548416 creator A5010340306 @default.
• W2103548416 creator A5013892045 @default.
• W2103548416 creator A5018182572 @default.
• W2103548416 creator A5029764881 @default.
• W2103548416 creator A5046588878 @default.
• W2103548416 creator A5051135936 @default.
• W2103548416 creator A5078646392 @default.
• W2103548416 date "2009-08-31" @default.
• W2103548416 modified "2023-10-16" @default.
• W2103548416 title "Erythropoietin Receptor Expression and Correlation to Tamoxifen Response and Prognosis in Breast Cancer" @default.
• W2103548416 cites W1504954730 @default.
• W2103548416 cites W155375556 @default.
• W2103548416 cites W1577577364 @default.
• W2103548416 cites W1607267312 @default.
• W2103548416 cites W1965419075 @default.
• W2103548416 cites W1967818195 @default.
• W2103548416 cites W1968046745 @default.
• W2103548416 cites W1969258314 @default.
• W2103548416 cites W1974106801 @default.
• W2103548416 cites W1987727256 @default.
• W2103548416 cites W1988242406 @default.
• W2103548416 cites W2000124620 @default.
• W2103548416 cites W2002189627 @default.
• W2103548416 cites W2005495277 @default.
• W2103548416 cites W2010386340 @default.
• W2103548416 cites W2019695814 @default.
• W2103548416 cites W2020989983 @default.
• W2103548416 cites W2025740574 @default.
• W2103548416 cites W2025917081 @default.
• W2103548416 cites W2031980124 @default.
• W2103548416 cites W2040827803 @default.
• W2103548416 cites W2043981867 @default.
• W2103548416 cites W2061776631 @default.
• W2103548416 cites W2070284936 @default.
• W2103548416 cites W2079527824 @default.
• W2103548416 cites W2081491080 @default.
• W2103548416 cites W2102546064 @default.
• W2103548416 cites W2119195886 @default.
• W2103548416 cites W2123681374 @default.
• W2103548416 cites W2131994307 @default.
• W2103548416 cites W2137490350 @default.
• W2103548416 cites W2142957794 @default.
• W2103548416 cites W2144296845 @default.
• W2103548416 cites W2152169567 @default.
• W2103548416 cites W2161032736 @default.
• W2103548416 cites W2162885883 @default.
• W2103548416 cites W2163066827 @default.
• W2103548416 cites W2164837040 @default.
• W2103548416 cites W4231292559 @default.
• W2103548416 cites W4256003647 @default.
• W2103548416 doi "https://doi.org/10.1158/1078-0432.ccr-08-3014" @default.
• W2103548416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19706814" @default.
• W2103548416 hasPublicationYear "2009" @default.
• W2103548416 type Work @default.
• W2103548416 sameAs 2103548416 @default.
• W2103548416 citedByCount "21" @default.
• W2103548416 countsByYear W21035484162012 @default.
• W2103548416 countsByYear W21035484162013 @default.
• W2103548416 countsByYear W21035484162014 @default.
• W2103548416 countsByYear W21035484162016 @default.
• W2103548416 countsByYear W21035484162017 @default.
• W2103548416 countsByYear W21035484162019 @default.
• W2103548416 countsByYear W21035484162021 @default.
• W2103548416 countsByYear W21035484162022 @default.
• W2103548416 crossrefType "journal-article" @default.
• W2103548416 hasAuthorship W2103548416A5010340306 @default.
• W2103548416 hasAuthorship W2103548416A5013892045 @default.
• W2103548416 hasAuthorship W2103548416A5018182572 @default.
• W2103548416 hasAuthorship W2103548416A5029764881 @default.
• W2103548416 hasAuthorship W2103548416A5046588878 @default.
• W2103548416 hasAuthorship W2103548416A5051135936 @default.
• W2103548416 hasAuthorship W2103548416A5078646392 @default.
• W2103548416 hasBestOaLocation W21035484161 @default.
• W2103548416 hasConcept C121608353 @default.
• W2103548416 hasConcept C126322002 @default.
• W2103548416 hasConcept C134018914 @default.
• W2103548416 hasConcept C143998085 @default.
• W2103548416 hasConcept C193270364 @default.
• W2103548416 hasConcept C204232928 @default.
• W2103548416 hasConcept C2776067312 @default.
• W2103548416 hasConcept C2777176818 @default.
• W2103548416 hasConcept C2778001805 @default.
• W2103548416 hasConcept C2778534260 @default.
• W2103548416 hasConcept C31102739 @default.
• W2103548416 hasConcept C502942594 @default.
• W2103548416 hasConcept C530470458 @default.
• W2103548416 hasConcept C71924100 @default.
• W2103548416 hasConcept C84606932 @default.
• W2103548416 hasConcept C86803240 @default.
• W2103548416 hasConceptScore W2103548416C121608353 @default.
• W2103548416 hasConceptScore W2103548416C126322002 @default.
• W2103548416 hasConceptScore W2103548416C134018914 @default.
• W2103548416 hasConceptScore W2103548416C143998085 @default.
• W2103548416 hasConceptScore W2103548416C193270364 @default.
• W2103548416 hasConceptScore W2103548416C204232928 @default.
• W2103548416 hasConceptScore W2103548416C2776067312 @default.

• next