FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103553504> ?p ?o ?g. }

• W2103553504 endingPage "498" @default.
• W2103553504 startingPage "489" @default.
• W2103553504 abstract "Abstract Malignant tumors arise, in part, because the immune system does not adequately recognize and destroy them. Expression of indoleamine-2,3-dioxygenase (IDO; IDO1), a rate-limiting enzyme in the catabolism of tryptophan into kynurenine, contributes to this immune evasion. Here we describe the effects of systemic IDO inhibition using orally active hydroxyamidine small molecule inhibitors. A single dose of INCB023843 or INCB024360 results in efficient and durable suppression of Ido1 activity in the plasma of treated mice and dogs, the former to levels seen in Ido1-deficient mice. Hydroxyamidines potently suppress tryptophan metabolism in vitro in CT26 colon carcinoma and PAN02 pancreatic carcinoma cells and in vivo in tumors and their draining lymph nodes. Repeated administration of these IDO1 inhibitors impedes tumor growth in a dose- and lymphocyte-dependent fashion and is well tolerated in efficacy and preclinical toxicology studies. Substantiating the fundamental role of tumor cell–derived IDO expression, hydroxyamidines control the growth of IDO-expressing tumors in Ido1-deficient mice. These activities can be attributed, at least partially, to the increased immunoreactivity of lymphocytes found in tumors and their draining lymph nodes and to the reduction in tumor-associated regulatory T cells. INCB024360, a potent IDO1 inhibitor with desirable pharmaceutical properties, is poised to start clinical trials in cancer patients. Mol Cancer Ther; 9(2); 489–98" @default.
• W2103553504 created "2016-06-24" @default.
• W2103553504 creator A5005999476 @default.
• W2103553504 creator A5014354861 @default.
• W2103553504 creator A5017603782 @default.
• W2103553504 creator A5018193992 @default.
• W2103553504 creator A5018886805 @default.
• W2103553504 creator A5022438790 @default.
• W2103553504 creator A5023090545 @default.
• W2103553504 creator A5027146475 @default.
• W2103553504 creator A5041340848 @default.
• W2103553504 creator A5046355139 @default.
• W2103553504 creator A5059677466 @default.
• W2103553504 creator A5076020307 @default.
• W2103553504 creator A5076394182 @default.
• W2103553504 creator A5088797925 @default.
• W2103553504 date "2010-02-01" @default.
• W2103553504 modified "2023-10-01" @default.
• W2103553504 title "Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors" @default.
• W2103553504 cites W1757421115 @default.
• W2103553504 cites W1966912859 @default.
• W2103553504 cites W1973251492 @default.
• W2103553504 cites W1978992242 @default.
• W2103553504 cites W1987171603 @default.
• W2103553504 cites W1991075838 @default.
• W2103553504 cites W1991243877 @default.
• W2103553504 cites W2002267497 @default.
• W2103553504 cites W2015058212 @default.
• W2103553504 cites W2024000351 @default.
• W2103553504 cites W2030410453 @default.
• W2103553504 cites W2044160434 @default.
• W2103553504 cites W2053217888 @default.
• W2103553504 cites W2071514741 @default.
• W2103553504 cites W2073144071 @default.
• W2103553504 cites W2086167770 @default.
• W2103553504 cites W2089346214 @default.
• W2103553504 cites W2091540351 @default.
• W2103553504 cites W2111769244 @default.
• W2103553504 cites W2113846910 @default.
• W2103553504 cites W2120937496 @default.
• W2103553504 cites W2122012981 @default.
• W2103553504 cites W2127191483 @default.
• W2103553504 cites W2127903252 @default.
• W2103553504 cites W2141579931 @default.
• W2103553504 cites W2149244682 @default.
• W2103553504 cites W2154879572 @default.
• W2103553504 cites W2156222101 @default.
• W2103553504 cites W2156305611 @default.
• W2103553504 cites W2161550811 @default.
• W2103553504 cites W2162234205 @default.
• W2103553504 cites W2162646864 @default.
• W2103553504 cites W2338699203 @default.
• W2103553504 cites W2344411250 @default.
• W2103553504 doi "https://doi.org/10.1158/1535-7163.mct-09-0628" @default.
• W2103553504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20124451" @default.
• W2103553504 hasPublicationYear "2010" @default.
• W2103553504 type Work @default.
• W2103553504 sameAs 2103553504 @default.
• W2103553504 citedByCount "220" @default.
• W2103553504 countsByYear W21035535042012 @default.
• W2103553504 countsByYear W21035535042013 @default.
• W2103553504 countsByYear W21035535042014 @default.
• W2103553504 countsByYear W21035535042015 @default.
• W2103553504 countsByYear W21035535042016 @default.
• W2103553504 countsByYear W21035535042017 @default.
• W2103553504 countsByYear W21035535042018 @default.
• W2103553504 countsByYear W21035535042019 @default.
• W2103553504 countsByYear W21035535042020 @default.
• W2103553504 countsByYear W21035535042021 @default.
• W2103553504 countsByYear W21035535042022 @default.
• W2103553504 countsByYear W21035535042023 @default.
• W2103553504 crossrefType "journal-article" @default.
• W2103553504 hasAuthorship W2103553504A5005999476 @default.
• W2103553504 hasAuthorship W2103553504A5014354861 @default.
• W2103553504 hasAuthorship W2103553504A5017603782 @default.
• W2103553504 hasAuthorship W2103553504A5018193992 @default.
• W2103553504 hasAuthorship W2103553504A5018886805 @default.
• W2103553504 hasAuthorship W2103553504A5022438790 @default.
• W2103553504 hasAuthorship W2103553504A5023090545 @default.
• W2103553504 hasAuthorship W2103553504A5027146475 @default.
• W2103553504 hasAuthorship W2103553504A5041340848 @default.
• W2103553504 hasAuthorship W2103553504A5046355139 @default.
• W2103553504 hasAuthorship W2103553504A5059677466 @default.
• W2103553504 hasAuthorship W2103553504A5076020307 @default.
• W2103553504 hasAuthorship W2103553504A5076394182 @default.
• W2103553504 hasAuthorship W2103553504A5088797925 @default.
• W2103553504 hasBestOaLocation W21035535041 @default.
• W2103553504 hasConcept C121608353 @default.
• W2103553504 hasConcept C126322002 @default.
• W2103553504 hasConcept C150903083 @default.
• W2103553504 hasConcept C203014093 @default.
• W2103553504 hasConcept C207001950 @default.
• W2103553504 hasConcept C2776706248 @default.
• W2103553504 hasConcept C2777503454 @default.
• W2103553504 hasConcept C502942594 @default.
• W2103553504 hasConcept C515207424 @default.
• W2103553504 hasConcept C55493867 @default.
• W2103553504 hasConcept C62112901 @default.

• next