FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103554410> ?p ?o ?g. }

• W2103554410 endingPage "947" @default.
• W2103554410 startingPage "941" @default.
• W2103554410 abstract "Background/Aims: The aim of this study was to assess the effect of interleukin-6 (IL-6) on the proliferation of hepatocytes and to study the interaction between IL-6 and hepatocyte growth factor (HGF) in vivo. Methods: IL-6 was injected at a dose of 200 μg/mg subcutaneously into rats every day for 14 days. Liver and blood samples were obtained at 1, 3, 7 and 14 days during IL-6 administration. Hepatocyte proliferative activity of sera was measured using 3H-thymidine incorporation into cultured rat hepatocytes. To evaluate the proliferative activity of the hepatocytes in tissue sections, hepatic DNA content and immunostaining of the liver tissue sections for proliferating cell nuclear antigen (PCNA) were performed. Plasma HGF levels were measured using specific EIA. In addition, total RNA was extracted from the liver and expression of HGF mRNA was detected by RT-PCR. Results: The DNA contents of liver taken from IL-6-treated rats were increased during IL-6 administration compared with untreated rats. Sera taken from IL-6-treated rats at various intervals during administration also significantly increased 3H-thymidine incorporation by cultured rat hepatocytes compared with sera from untreated rats, suppressing 3H-thymidine incorporation at day 1 and 3 by anti-HGF antibody. IL-6 itself did not increase 3H-thymidine incorporation. Increased expression of PCNA in these hepatocytes was noted from 1 day after IL-6 administration, and at 14 days, the number of PCNA-positive cells was sevenfold greater than in the livers of untreated rats. However, plasma HGF levels showed a peak at day 1, decreased gradually from day 3, and became undetectable by day 14. HGF mRNA expression in livers of IL-6-treated rats was suppressed from day 3 to day 14 of IL-6 administration. Conclusions: These data show that IL-6 induces an early phase of liver cell growth in vivo and suggest that an increase level of HGF mediates this effect." @default.
• W2103554410 created "2016-06-24" @default.
• W2103554410 creator A5036475624 @default.
• W2103554410 creator A5037421364 @default.
• W2103554410 creator A5041323186 @default.
• W2103554410 creator A5047154345 @default.
• W2103554410 creator A5061508002 @default.
• W2103554410 creator A5063908844 @default.
• W2103554410 creator A5074859428 @default.
• W2103554410 creator A5076571038 @default.
• W2103554410 creator A5084712550 @default.
• W2103554410 creator A5091064461 @default.
• W2103554410 date "1996-12-01" @default.
• W2103554410 modified "2023-10-18" @default.
• W2103554410 title "Interleukin-6 induces proliferation of rat hepatocytes in vivo" @default.
• W2103554410 cites W1563645938 @default.
• W2103554410 cites W1570782716 @default.
• W2103554410 cites W1775749144 @default.
• W2103554410 cites W1966398859 @default.
• W2103554410 cites W1974652824 @default.
• W2103554410 cites W1996389318 @default.
• W2103554410 cites W1996497126 @default.
• W2103554410 cites W1999921831 @default.
• W2103554410 cites W2005782838 @default.
• W2103554410 cites W2013296666 @default.
• W2103554410 cites W2035331137 @default.
• W2103554410 cites W2050661529 @default.
• W2103554410 cites W2060912271 @default.
• W2103554410 cites W2063529172 @default.
• W2103554410 cites W2079371318 @default.
• W2103554410 cites W2127689401 @default.
• W2103554410 cites W2132286068 @default.
• W2103554410 cites W4239008863 @default.
• W2103554410 doi "https://doi.org/10.1016/s0168-8278(96)80300-x" @default.
• W2103554410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9007724" @default.
• W2103554410 hasPublicationYear "1996" @default.
• W2103554410 type Work @default.
• W2103554410 sameAs 2103554410 @default.
• W2103554410 citedByCount "39" @default.
• W2103554410 countsByYear W21035544102012 @default.
• W2103554410 countsByYear W21035544102017 @default.
• W2103554410 countsByYear W21035544102018 @default.
• W2103554410 crossrefType "journal-article" @default.
• W2103554410 hasAuthorship W2103554410A5036475624 @default.
• W2103554410 hasAuthorship W2103554410A5037421364 @default.
• W2103554410 hasAuthorship W2103554410A5041323186 @default.
• W2103554410 hasAuthorship W2103554410A5047154345 @default.
• W2103554410 hasAuthorship W2103554410A5061508002 @default.
• W2103554410 hasAuthorship W2103554410A5063908844 @default.
• W2103554410 hasAuthorship W2103554410A5074859428 @default.
• W2103554410 hasAuthorship W2103554410A5076571038 @default.
• W2103554410 hasAuthorship W2103554410A5084712550 @default.
• W2103554410 hasAuthorship W2103554410A5091064461 @default.
• W2103554410 hasConcept C126322002 @default.
• W2103554410 hasConcept C134018914 @default.
• W2103554410 hasConcept C150903083 @default.
• W2103554410 hasConcept C153911025 @default.
• W2103554410 hasConcept C170493617 @default.
• W2103554410 hasConcept C185592680 @default.
• W2103554410 hasConcept C202751555 @default.
• W2103554410 hasConcept C204232928 @default.
• W2103554410 hasConcept C207001950 @default.
• W2103554410 hasConcept C2776200302 @default.
• W2103554410 hasConcept C2776996007 @default.
• W2103554410 hasConcept C2777108182 @default.
• W2103554410 hasConcept C34688535 @default.
• W2103554410 hasConcept C4224716 @default.
• W2103554410 hasConcept C55493867 @default.
• W2103554410 hasConcept C62112901 @default.
• W2103554410 hasConcept C64241487 @default.
• W2103554410 hasConcept C71924100 @default.
• W2103554410 hasConcept C86803240 @default.
• W2103554410 hasConceptScore W2103554410C126322002 @default.
• W2103554410 hasConceptScore W2103554410C134018914 @default.
• W2103554410 hasConceptScore W2103554410C150903083 @default.
• W2103554410 hasConceptScore W2103554410C153911025 @default.
• W2103554410 hasConceptScore W2103554410C170493617 @default.
• W2103554410 hasConceptScore W2103554410C185592680 @default.
• W2103554410 hasConceptScore W2103554410C202751555 @default.
• W2103554410 hasConceptScore W2103554410C204232928 @default.
• W2103554410 hasConceptScore W2103554410C207001950 @default.
• W2103554410 hasConceptScore W2103554410C2776200302 @default.
• W2103554410 hasConceptScore W2103554410C2776996007 @default.
• W2103554410 hasConceptScore W2103554410C2777108182 @default.
• W2103554410 hasConceptScore W2103554410C34688535 @default.
• W2103554410 hasConceptScore W2103554410C4224716 @default.
• W2103554410 hasConceptScore W2103554410C55493867 @default.
• W2103554410 hasConceptScore W2103554410C62112901 @default.
• W2103554410 hasConceptScore W2103554410C64241487 @default.
• W2103554410 hasConceptScore W2103554410C71924100 @default.
• W2103554410 hasConceptScore W2103554410C86803240 @default.
• W2103554410 hasIssue "6" @default.
• W2103554410 hasLocation W21035544101 @default.
• W2103554410 hasLocation W21035544102 @default.
• W2103554410 hasOpenAccess W2103554410 @default.
• W2103554410 hasPrimaryLocation W21035544101 @default.
• W2103554410 hasRelatedWork W1990709240 @default.
• W2103554410 hasRelatedWork W2016278271 @default.

• next