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- W2103560669 abstract "A critical step in the viral life cycle of ds DNA viruses such as Adenovirus, Bacteriophage lambda and Herpes, is the encapsidation of the viral genome. In human Adenovirus, this step is initiated by the assembly of two viral proteins, called IVa2 and L4-22K, onto conserved sequences within the viral genome. Genetic studies have shown that a critical feature of these sequences is that multiple copies are present, which strongly suggests that heterotropic cooperative interactions between these two proteins control the viral decision to initiate the genome encapsidation reaction. Precise control of the viruses decision to begin to manufacture viral particles is required to optimize virus particle numbers. Here we apply rigorous hydrodynamic and thermodynamic approaches to investigate the equilibrium mechanism of assembly onto viral DNA. Based on these data, we propose a detailed biochemical model which provides, for the first time, a predictive understanding of the regulation of viral DNA packaging." @default.
- W2103560669 created "2016-06-24" @default.
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- W2103560669 date "2011-02-01" @default.
- W2103560669 modified "2023-10-17" @default.
- W2103560669 title "Assembly of the Adenoviral IVa2 and L4-22K Proteins on a Viral DNA Packaging Sequence" @default.
- W2103560669 doi "https://doi.org/10.1016/j.bpj.2010.12.2386" @default.
- W2103560669 hasPublicationYear "2011" @default.
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