Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103564124> ?p ?o ?g. }
- W2103564124 abstract "The objectives of this thesis were to study cerebral serotonin transporters (SERT) in the diencephalon and striatal dopamine transporters (DAT) in humans in different metabolic conditions (i.e. lean, obese and insulin resistant state) in relation to feeding behavior and to investigate the early consequences of overeating on diencephalic SERT and striatal DAT, on a number of metabolic parameters including fat accumulation and insulin sensitivity, and on the autonomic nervous system in lean humans. To do this, we performed a hypercaloric diet study with 4 hypercaloric diets with different meal pattern and diet composition. We measured several metabolic parameters, serotonin and dopamine transporters (SERT and DAT) in the brain, behavioral outcomes and central nervous system activity. In addition, we measured metabolic outcomes and brain SERT and DAT in obese humans with or without insulin resistance and matched lean controls. In this thesis we show that SERT and DAT in the human brain are involved in food motivated behavior and that SERT is reduced in the hypothalamus of overweight/ obese subjects and particularly in obese women with insulin resistance. Moreover we provide evidence that consuming high-fat-high-sugar snacks in excess of caloric need reduces SERT in the diencephalon and reduces hepatic insulin sensitivity in addition to the negative effects of snacking on liver and abdominal fat accumulation. Increasing meal size only did not show these effects pointing to an independent effect of hypercaloric snacking behavior on peripheral glucose metabolism and on brain circuitries involved in feeding behavior and central control of glucose metabolism." @default.
- W2103564124 created "2016-06-24" @default.
- W2103564124 creator A5061560220 @default.
- W2103564124 date "2014-01-01" @default.
- W2103564124 modified "2023-09-27" @default.
- W2103564124 title "Central serotonin and dopamine transporters in overeating, obesity and insulin resistance" @default.
- W2103564124 cites W1484306029 @default.
- W2103564124 cites W1512522692 @default.
- W2103564124 cites W1515329225 @default.
- W2103564124 cites W1549657738 @default.
- W2103564124 cites W1709672860 @default.
- W2103564124 cites W1776600295 @default.
- W2103564124 cites W1849760882 @default.
- W2103564124 cites W1864797938 @default.
- W2103564124 cites W1967881863 @default.
- W2103564124 cites W1968545401 @default.
- W2103564124 cites W1970993456 @default.
- W2103564124 cites W1972151139 @default.
- W2103564124 cites W1972520687 @default.
- W2103564124 cites W1975846239 @default.
- W2103564124 cites W1979565994 @default.
- W2103564124 cites W1980557031 @default.
- W2103564124 cites W1983467559 @default.
- W2103564124 cites W1985592156 @default.
- W2103564124 cites W1988028110 @default.
- W2103564124 cites W1989802774 @default.
- W2103564124 cites W1991893150 @default.
- W2103564124 cites W1993642953 @default.
- W2103564124 cites W1998028256 @default.
- W2103564124 cites W1999351864 @default.
- W2103564124 cites W2000232109 @default.
- W2103564124 cites W2001510740 @default.
- W2103564124 cites W2001562531 @default.
- W2103564124 cites W2002532911 @default.
- W2103564124 cites W2003413351 @default.
- W2103564124 cites W2009278051 @default.
- W2103564124 cites W2016476659 @default.
- W2103564124 cites W2020047056 @default.
- W2103564124 cites W2020980272 @default.
- W2103564124 cites W2025128166 @default.
- W2103564124 cites W2031153362 @default.
- W2103564124 cites W2035001090 @default.
- W2103564124 cites W2036956142 @default.
- W2103564124 cites W2038783185 @default.
- W2103564124 cites W2039849925 @default.
- W2103564124 cites W2045084840 @default.
- W2103564124 cites W2045278261 @default.
- W2103564124 cites W2046045427 @default.
- W2103564124 cites W2051448042 @default.
- W2103564124 cites W2056843772 @default.
- W2103564124 cites W2057683939 @default.
- W2103564124 cites W2059325999 @default.
- W2103564124 cites W2059366384 @default.
- W2103564124 cites W2059726811 @default.
- W2103564124 cites W2060392637 @default.
- W2103564124 cites W2063450581 @default.
- W2103564124 cites W2064329557 @default.
- W2103564124 cites W2064936475 @default.
- W2103564124 cites W2067859532 @default.
- W2103564124 cites W2068515505 @default.
- W2103564124 cites W2069600955 @default.
- W2103564124 cites W2069762648 @default.
- W2103564124 cites W2074370892 @default.
- W2103564124 cites W2074989227 @default.
- W2103564124 cites W2079395662 @default.
- W2103564124 cites W2081104414 @default.
- W2103564124 cites W2081478664 @default.
- W2103564124 cites W2089253166 @default.
- W2103564124 cites W2092703117 @default.
- W2103564124 cites W2093085769 @default.
- W2103564124 cites W2099421491 @default.
- W2103564124 cites W2102312935 @default.
- W2103564124 cites W2103135709 @default.
- W2103564124 cites W2107721366 @default.
- W2103564124 cites W2109386189 @default.
- W2103564124 cites W2111248735 @default.
- W2103564124 cites W2111951188 @default.
- W2103564124 cites W2117340355 @default.
- W2103564124 cites W2122063356 @default.
- W2103564124 cites W2123468633 @default.
- W2103564124 cites W2124232607 @default.
- W2103564124 cites W2128280806 @default.
- W2103564124 cites W2130087327 @default.
- W2103564124 cites W2130172549 @default.
- W2103564124 cites W2130189158 @default.
- W2103564124 cites W2131501155 @default.
- W2103564124 cites W2132279532 @default.
- W2103564124 cites W2133589238 @default.
- W2103564124 cites W2137890984 @default.
- W2103564124 cites W2142658017 @default.
- W2103564124 cites W2144459143 @default.
- W2103564124 cites W2145894102 @default.
- W2103564124 cites W2146966453 @default.
- W2103564124 cites W2148402277 @default.
- W2103564124 cites W2151211427 @default.
- W2103564124 cites W2151736176 @default.
- W2103564124 cites W2156339883 @default.
- W2103564124 cites W2158287537 @default.
- W2103564124 cites W2160283765 @default.
- W2103564124 cites W2163805252 @default.