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- W2103580875 abstract "The premature death (p) mutation in the Mexican axolotl (Ambystoma mexicanum) affects the ability of ectoderm to produce normal neural crest cells. We have examined the effect of this mutation on the development of a derivative of placodal ectoderm—the lateral-line system—and found that both migration of lateral-line primordia and differentiation of mechanoreceptive neuromast organs are disrupted in p/p embryos. These effects cannot be explained by the presence of other mutant tissues, since development is also abnormal when lateral-line placodes from mutant embryos are transplanted into wild-type hosts. Furthermore, wild-type placodes develop normally in mutant embryos. Thus, the p gene affects both placodal and neural crest cell development. These results strongly suggest that neural crest cells and placodal ectoderm arise in response to common developmental interactions, which could indicate that they were derived from an ancestral precursor tissue. © 1994 Wiley-Liss, Inc." @default.
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- W2103580875 date "1994-11-01" @default.
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- W2103580875 title "Evidence for a developmental and evolutionary link between placodal ectoderm and neural crest" @default.
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- W2103580875 doi "https://doi.org/10.1002/jez.1402700308" @default.
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