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• W2103581475 abstract "P048 Factors affecting post-operative recurrence in Crohn’s disease A. Ouakaa-Kchaou*, N. Ben Mahmoud, H. Elloumi, D. Gargouri, R. Hefaiedh, A. Kochlef, A. Kilani, M. Romani, J. Kharrat, A. Ghorbel. Habib Thameur Hospital, Tunis, Tunisia Background: Crohn’s disease is a chronic inflammatory gastrointestinal disorder with an unpredictable clinical course characterized by the high incidence of recurrence. In spite of the important role of conservative treatment, up to 90 % of all patients with Crohn’s disease require surgery during their lifetime. However, the factors that predict post-operative recurrence remain controversial. Aim: This study was designed to identify the risk factors for recurrence in patients with Crohn’s disease and the influence of the primary operation. Methods: From 1994 through 2006, 40 patients affected by Crohn’s disease required operative treatment. All these patients underwent a primary procedure. There were 29 men and 11 women (mean age: 33 years). Recurrence was defined by the presence of clinical symptoms. Univariate and multivariate analysis were performed to find the predictors of recurrence. Results: The most common indication for the surgical treatment was stenosis (45%). As the most frequent procedures, the ileocoecal resection (37.5%) and the partial resection of the small bowel (32.5%) were performed. The mean length of the follow-up was 48 months. The overall recurrence rate was 40%. Logistic regression analysis revealed that age at onset of disease (p = 0.01), age at surgery (p = 0.02), smoking (p = 0.005), preoperative treatment (p = 0.04), urgent surgery (p = 0.03) and prophylactic medical treatment (p = 0.00) were associated with the risk of recurrence. Neither gender, form of aggressiveness of the disease, duration of Crohn’s disease before surgery and anatomical site of involvement, nor microscopically affected resection margins and typical granulomas were found to predict the recurrence of the disease. Conclusion: In the treatment of Crohn’s disease, it is important to identify a group with high risk of recurrence in order to undertake an appropriate medical prophylaxis. This is very important because of the higher risk for complications caused by reoperations. That is why interdisciplinary cooperation including postoperative care and optimal conservative treatment are absolutely essential." @default.
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• W2103581475 date "2009-02-01" @default.
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• W2103581475 title "P049 - The value of capsule endoscopy for the phenotypic classification and the management of patients with Crohn's disease" @default.
• W2103581475 doi "https://doi.org/10.1016/s1873-9946(09)60076-3" @default.
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