Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103584104> ?p ?o ?g. }
- W2103584104 endingPage "1333" @default.
- W2103584104 startingPage "1326" @default.
- W2103584104 abstract "Alum-adsorbed BBG2Na, a recombinant vaccine derived in part from the respiratory syncytial virus (RSV) subgroup A G protein, induced moderate antibody titers after 1 immunization in 1-week-old mice but conferred complete lung protection upon RSV challenge. The anti-BBG2Na IgG1-IgG2a neonatal isotype profile was suggestive of dominant Th2 responses compared with those in adults. Formulation of BBG2Na with a Th1-driving adjuvant efficiently shifted neonatal responses toward a more balanced and adultlike IgG1-IgG2a profile without compromising its protective efficacy. BBG2Na-induced protective immunity was maintained even after early life immunization in the presence of high titers of maternal antibodies. Under these conditions, the protective efficacy (86%-100%) reflected the high capacity of the nonglycosylated G2Na immunogen to escape inhibition by RSV-A-induced maternal antibodies. Thus, immunization with BBG2Na protected against viral challenge despite neonatal immunologic immaturity and the presence of maternal antibodies, two major obstacles to neonatal RSV vaccine development." @default.
- W2103584104 created "2016-06-24" @default.
- W2103584104 creator A5001026624 @default.
- W2103584104 creator A5030631117 @default.
- W2103584104 creator A5036648745 @default.
- W2103584104 creator A5042537374 @default.
- W2103584104 creator A5050894666 @default.
- W2103584104 creator A5059672970 @default.
- W2103584104 creator A5074268731 @default.
- W2103584104 creator A5080640332 @default.
- W2103584104 date "1999-06-01" @default.
- W2103584104 modified "2023-10-18" @default.
- W2103584104 title "Protective Efficacy against Respiratory Syncytial Virus following Murine Neonatal Immunization with BBG2Na Vaccine: Influence of Adjuvants and Maternal Antibodies" @default.
- W2103584104 cites W1511209971 @default.
- W2103584104 cites W1525273492 @default.
- W2103584104 cites W1534531493 @default.
- W2103584104 cites W1554745563 @default.
- W2103584104 cites W1572013878 @default.
- W2103584104 cites W1673458349 @default.
- W2103584104 cites W1885601830 @default.
- W2103584104 cites W1887285520 @default.
- W2103584104 cites W1898933481 @default.
- W2103584104 cites W1913350003 @default.
- W2103584104 cites W1919840375 @default.
- W2103584104 cites W1929856540 @default.
- W2103584104 cites W1967838120 @default.
- W2103584104 cites W1972941257 @default.
- W2103584104 cites W1983808349 @default.
- W2103584104 cites W1987410181 @default.
- W2103584104 cites W1993953211 @default.
- W2103584104 cites W1994088766 @default.
- W2103584104 cites W1996443074 @default.
- W2103584104 cites W2003250816 @default.
- W2103584104 cites W2011589552 @default.
- W2103584104 cites W2023832218 @default.
- W2103584104 cites W2025391611 @default.
- W2103584104 cites W2027729283 @default.
- W2103584104 cites W2067239231 @default.
- W2103584104 cites W2075430281 @default.
- W2103584104 cites W2083613414 @default.
- W2103584104 cites W2086275027 @default.
- W2103584104 cites W2121744159 @default.
- W2103584104 cites W2128547646 @default.
- W2103584104 cites W2131880147 @default.
- W2103584104 cites W2136540289 @default.
- W2103584104 cites W2144159905 @default.
- W2103584104 cites W2147890600 @default.
- W2103584104 cites W2151393053 @default.
- W2103584104 cites W2154567574 @default.
- W2103584104 cites W2163813388 @default.
- W2103584104 cites W2169767874 @default.
- W2103584104 cites W2324251256 @default.
- W2103584104 cites W2395422949 @default.
- W2103584104 cites W2007121055 @default.
- W2103584104 doi "https://doi.org/10.1086/314778" @default.
- W2103584104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10228051" @default.
- W2103584104 hasPublicationYear "1999" @default.
- W2103584104 type Work @default.
- W2103584104 sameAs 2103584104 @default.
- W2103584104 citedByCount "66" @default.
- W2103584104 countsByYear W21035841042013 @default.
- W2103584104 countsByYear W21035841042014 @default.
- W2103584104 countsByYear W21035841042015 @default.
- W2103584104 countsByYear W21035841042017 @default.
- W2103584104 countsByYear W21035841042019 @default.
- W2103584104 countsByYear W21035841042020 @default.
- W2103584104 countsByYear W21035841042021 @default.
- W2103584104 crossrefType "journal-article" @default.
- W2103584104 hasAuthorship W2103584104A5001026624 @default.
- W2103584104 hasAuthorship W2103584104A5030631117 @default.
- W2103584104 hasAuthorship W2103584104A5036648745 @default.
- W2103584104 hasAuthorship W2103584104A5042537374 @default.
- W2103584104 hasAuthorship W2103584104A5050894666 @default.
- W2103584104 hasAuthorship W2103584104A5059672970 @default.
- W2103584104 hasAuthorship W2103584104A5074268731 @default.
- W2103584104 hasAuthorship W2103584104A5080640332 @default.
- W2103584104 hasBestOaLocation W21035841041 @default.
- W2103584104 hasConcept C159047783 @default.
- W2103584104 hasConcept C159654299 @default.
- W2103584104 hasConcept C203014093 @default.
- W2103584104 hasConcept C22070199 @default.
- W2103584104 hasConcept C22889606 @default.
- W2103584104 hasConcept C2522874641 @default.
- W2103584104 hasConcept C2777863537 @default.
- W2103584104 hasConcept C2778668663 @default.
- W2103584104 hasConcept C2779341262 @default.
- W2103584104 hasConcept C2779909307 @default.
- W2103584104 hasConcept C2780801004 @default.
- W2103584104 hasConcept C32611913 @default.
- W2103584104 hasConcept C542903549 @default.
- W2103584104 hasConcept C71924100 @default.
- W2103584104 hasConcept C8891405 @default.
- W2103584104 hasConceptScore W2103584104C159047783 @default.
- W2103584104 hasConceptScore W2103584104C159654299 @default.
- W2103584104 hasConceptScore W2103584104C203014093 @default.
- W2103584104 hasConceptScore W2103584104C22070199 @default.
- W2103584104 hasConceptScore W2103584104C22889606 @default.
- W2103584104 hasConceptScore W2103584104C2522874641 @default.