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• W2103585434 abstract "Objectives . The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-B immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods . Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas). Results . COX-2 expression is increased in the cytoplasm of bladder cells, during loss of cell differentiation (, ) and in muscle invasive carcinomas (). A strong positive association between tumor grade and nuclear expression of NFB has been established. A positive correlation between COX-2 and nuclear NFB immunoreactivity was observed. Conclusions . The possible coordinated upregulation of NFB and COX-2, during bladder carcinogenesis, indicates that agents inhibitors of these two molecules may represent a possible new treatment strategy, by virtue of their role in bladder carcinogenesis." @default.
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• W2103585434 date "2010-01-01" @default.
• W2103585434 modified "2023-09-26" @default.
• W2103585434 title "Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor B Is a Steady Feature of Urinary Bladder Carcinogenesis" @default.
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• W2103585434 doi "https://doi.org/10.1155/2010/871356" @default.
• W2103585434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2933857" @default.
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