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• W2103603242 abstract "Multiple sclerosis is an inflammatory demyelinating disease of the CNS. The histopathological pattern shows a continuous destruction of the myelin due to inflammatory lesions. Additionally, the disease is accompanied by a destruction of axonal and neuronal structures, which are one of the most important reasons for permanent disabilities of MS patients. All established concepts of treatment target at the inflammatory component of the disease. Due to the fact that modern MS therapies cannot stop the slowly progressing increase in persistent disabilities, the development of neuroprotective treatments, which restrict the irreversible neuronal damage, seems to be essential. This paper describes the evaluation of the effect of monoclonal antibodies targeting at the repulsive guidance molecule a (RGMa) in the animal model of the experimental autoimmune encephalomyelitis (EAE). RGMa is a guidance molecule that was found and characterized while exploring the neuronal development of the visual system. Moreover, an axon-regenerating effect was observed in a trauma model, when antagonizing the molecule. First, we performed analysis of expression, which confirmed that RGMa appears in neuronal structures. The comparison of preparations of healthy and EAE-rats showed an augmented appearance of RGMa in inflammatory demyelinating areas. The treatment with the antibodies was compared to the treatment with two placebos. One animal group was medicated with PBS as a placebo, the other group of control with a monoclonal antibody against human RGMa. The intraperitonal application of 1 or 4 mg/kg body weight verum showed no effect in Brown Norway rat with optic neuritis considering the inflammation of the optic nerve, the axonal degeneration and the neuronal cell death. The missing neuroprotective and anti-inflammatory impact was also seen in unchanged clinical deficits of the rats. The result of this experiment underlines the necessity of further experimental and clinical studies in order to decrypt the interaction of inflammation and degeneration of the MS and to develop a neuroprotective and anti-inflammatory monotherapy." @default.
• W2103603242 created "2016-06-24" @default.
• W2103603242 creator A5014188362 @default.
• W2103603242 date "2022-02-20" @default.
• W2103603242 modified "2023-09-30" @default.
• W2103603242 title "Die Wirkung eines RGMa-Antikörpers im Optikusneuritis-Modell" @default.
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