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- W2103604567 abstract "An increased function in the mesolimbic dopaminergic system has been extensively associated with the rewarding effects of both natural stimuli and drugs of abuse. Thus, dopamine receptor blockers, such as neuroleptic drugs, can be proposed as candidates for potential therapeutic approaches to treat drug dependence. Notwithstanding, this therapeutic potential of neuroleptics critically depends on a selective action on the specific mechanisms related to the development of addiction. We compared the effects of different doses of haloperidol, ziprasidone and aripiprazole (first-, second- and third-generation neuroleptics, respectively) on spontaneous locomotor activity of mice in a novel environment, hyperlocomotion induced by acute cocaine administration and cocaine-induced locomotor sensitization by a two-injection protocol. Whereas high doses of haloperidol abolished the three behavioural paradigms without selectivity, low doses of ziprasidone selectively abolished the development of the behavioural sensitization phenomenon. Finally, low doses of aripiprazole inhibited acute cocaine-induced hyperlocomotion and behavioural sensitization without modifying spontaneous locomotor activity. Thus, aripiprazole at lower doses was the most selective antipsychotic drug concerning the inhibition of the development of behavioural sensitization to cocaine. Because locomotor sensitization in rodents has been proposed to share plastic mechanisms with drug addiction in humans, our data provide relevant suggestions to the clinical practice." @default.
- W2103604567 created "2016-06-24" @default.
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- W2103604567 date "2013-12-17" @default.
- W2103604567 modified "2023-10-02" @default.
- W2103604567 title "Selective action of an atypical neuroleptic on the mechanisms related to the development of cocaine addiction: a pre-clinical behavioural study" @default.
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- W2103604567 cites W1570141004 @default.
- W2103604567 cites W1934926274 @default.
- W2103604567 cites W1943803076 @default.
- W2103604567 cites W1964899806 @default.
- W2103604567 cites W1971165967 @default.
- W2103604567 cites W1971179661 @default.
- W2103604567 cites W1972791221 @default.
- W2103604567 cites W1973799461 @default.
- W2103604567 cites W1975216040 @default.
- W2103604567 cites W1981219005 @default.
- W2103604567 cites W1986846918 @default.
- W2103604567 cites W1986854589 @default.
- W2103604567 cites W1990450584 @default.
- W2103604567 cites W1991238636 @default.
- W2103604567 cites W1997044850 @default.
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- W2103604567 cites W2000940102 @default.
- W2103604567 cites W2001677998 @default.
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- W2103604567 cites W2006821655 @default.
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- W2103604567 cites W2010870930 @default.
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- W2103604567 cites W2015006945 @default.
- W2103604567 cites W2015538348 @default.
- W2103604567 cites W2018825306 @default.
- W2103604567 cites W2022395708 @default.
- W2103604567 cites W2023785281 @default.
- W2103604567 cites W2025783554 @default.
- W2103604567 cites W2026615999 @default.
- W2103604567 cites W2029516351 @default.
- W2103604567 cites W2029986826 @default.
- W2103604567 cites W2031658048 @default.
- W2103604567 cites W2033608262 @default.
- W2103604567 cites W2033705393 @default.
- W2103604567 cites W2039828875 @default.
- W2103604567 cites W2042494118 @default.
- W2103604567 cites W2042578245 @default.
- W2103604567 cites W2043832903 @default.
- W2103604567 cites W2046346017 @default.
- W2103604567 cites W2046731194 @default.
- W2103604567 cites W2050247926 @default.
- W2103604567 cites W2050607774 @default.
- W2103604567 cites W2051814352 @default.
- W2103604567 cites W2056117721 @default.
- W2103604567 cites W2058744011 @default.
- W2103604567 cites W2060059942 @default.
- W2103604567 cites W2065639025 @default.
- W2103604567 cites W2066830094 @default.
- W2103604567 cites W2069798616 @default.
- W2103604567 cites W2072792161 @default.
- W2103604567 cites W2080059945 @default.
- W2103604567 cites W2080313651 @default.
- W2103604567 cites W2080572861 @default.
- W2103604567 cites W2082890691 @default.
- W2103604567 cites W2087683500 @default.
- W2103604567 cites W2095217951 @default.
- W2103604567 cites W2098515903 @default.
- W2103604567 cites W2106862702 @default.
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- W2103604567 cites W2122592499 @default.
- W2103604567 cites W2123328912 @default.
- W2103604567 cites W2129541348 @default.
- W2103604567 cites W2146938761 @default.
- W2103604567 cites W2156422754 @default.
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- W2103604567 cites W2168620692 @default.
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- W2103604567 doi "https://doi.org/10.1017/s1461145713001430" @default.
- W2103604567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24345415" @default.
- W2103604567 hasPublicationYear "2013" @default.
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