FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103606437> ?p ?o ?g. }

• W2103606437 abstract "Background: Detection of serum cryptococcal antigen (sCrAg) in HIV-infected patients is associated with 3-6 fold increased mortality. Studies on the feasibility and effectiveness of sCrAg-screening and pre-emptive therapy before antiretroviral treatment (ART) are limited. Amongst antiretroviral treatment-naive adults with baseline CD4 counts <100 cells/µL undergoing pre-ART sCrAg screening, without previous cryptococcal meningitis (CM), we report on the 1) prevalence of sCrAg-positivity; 2) proportion with concurrent CM; 3) six-month patient outcomes. Methods: This is a retrospective hospital-based cohort study evaluating a “screen-and-treat” protocol implemented between 10/2008 and 8/2012 in Phnom Penh, Cambodia. All sCrAg(+) patients underwent lumbar puncture (LP). After ruling-out CM, fluconazole was started (400mg/d-10 weeks; 200mg/d secondary prophylaxis) immediately. sCrAg(-) patients received primary prophylaxis (fluconazole 100mg/d). CM was treated with amphotericin-B (0.7mg/ kg-2 weeks, followed by fluconazole 400mg/day for 8 weeks). Results: A total of 357 patients were enrolled with a median age of 38 (IQR 31-43) years and median CD4 count of 28 (IQR 14-53) cells/µL; 54% were male, 20% had BMI <16 kg/m2. Thirty (8.4%) of 357 tested were sCrAg(+). Six (20%) of the 30 sCrAg(+) patients had concurrent CM with no/minimal symptoms. Two were treated as CM without LP done. Amongst sCrAg(+) patients, the following 6-month outcomes were noted: 25 (83.3%) were retained and on ART, 1 (3.3%) patient died and 4 (13.3%) were lost-to-follow-up. Excluding those treated for CM (n=8), one case (1/22; 4.5%) of incident CM was detected by month six. Corresponding 6-month outcomes amongst the 327 CrAg(-) patients were: 269 (82.3%) retained and on ART, 23 (7%) deaths, 29 (9%) lost-to-follow-up, 6 (1.8%) transferred-out. One case (1/327; 0.3%) of incident CM was documented. Conclusion: Outcomes of sCrAg(+) patients with the “screen-and-treat” approach were good. Fluconazole at 400mg/day appears appropriate for treatment of sCrAg(+) patients. Routine LP in sCrAg(+) might be indicated." @default.
• W2103606437 created "2016-06-24" @default.
• W2103606437 creator A5009410966 @default.
• W2103606437 creator A5021126631 @default.
• W2103606437 creator A5028128458 @default.
• W2103606437 creator A5045317610 @default.
• W2103606437 creator A5063869269 @default.
• W2103606437 creator A5082739891 @default.
• W2103606437 date "2013-01-01" @default.
• W2103606437 modified "2023-09-30" @default.
• W2103606437 title "Integrated Cryptococcal Antigen Screening and Pre-Emptive Treatment Prior to Initiation of Antiretroviral Treatment in Cambodia" @default.
• W2103606437 cites W1806692586 @default.
• W2103606437 cites W1964188845 @default.
• W2103606437 cites W1991321426 @default.
• W2103606437 cites W2006263719 @default.
• W2103606437 cites W2028893274 @default.
• W2103606437 cites W2066915351 @default.
• W2103606437 cites W2073363331 @default.
• W2103606437 cites W2077109508 @default.
• W2103606437 cites W2079513681 @default.
• W2103606437 cites W2081488265 @default.
• W2103606437 cites W2094977131 @default.
• W2103606437 cites W2101961938 @default.
• W2103606437 cites W2107740974 @default.
• W2103606437 cites W2113358982 @default.
• W2103606437 cites W2119878310 @default.
• W2103606437 cites W2121822883 @default.
• W2103606437 cites W2127250507 @default.
• W2103606437 cites W2139368207 @default.
• W2103606437 cites W2146499128 @default.
• W2103606437 cites W2146627546 @default.
• W2103606437 cites W2148609341 @default.
• W2103606437 cites W2149684675 @default.
• W2103606437 cites W2153871762 @default.
• W2103606437 cites W2161173327 @default.
• W2103606437 cites W2164448442 @default.
• W2103606437 doi "https://doi.org/10.4172/2155-6113.1000227" @default.
• W2103606437 hasPublicationYear "2013" @default.
• W2103606437 type Work @default.
• W2103606437 sameAs 2103606437 @default.
• W2103606437 citedByCount "4" @default.
• W2103606437 countsByYear W21036064372015 @default.
• W2103606437 countsByYear W21036064372016 @default.
• W2103606437 crossrefType "journal-article" @default.
• W2103606437 hasAuthorship W2103606437A5009410966 @default.
• W2103606437 hasAuthorship W2103606437A5021126631 @default.
• W2103606437 hasAuthorship W2103606437A5028128458 @default.
• W2103606437 hasAuthorship W2103606437A5045317610 @default.
• W2103606437 hasAuthorship W2103606437A5063869269 @default.
• W2103606437 hasAuthorship W2103606437A5082739891 @default.
• W2103606437 hasBestOaLocation W21036064371 @default.
• W2103606437 hasConcept C142462285 @default.
• W2103606437 hasConcept C147483822 @default.
• W2103606437 hasConcept C157585117 @default.
• W2103606437 hasConcept C159047783 @default.
• W2103606437 hasConcept C16005928 @default.
• W2103606437 hasConcept C177713679 @default.
• W2103606437 hasConcept C203014093 @default.
• W2103606437 hasConcept C2779548794 @default.
• W2103606437 hasConcept C2909254382 @default.
• W2103606437 hasConcept C2993143319 @default.
• W2103606437 hasConcept C3013748606 @default.
• W2103606437 hasConcept C3019165603 @default.
• W2103606437 hasConcept C60644358 @default.
• W2103606437 hasConcept C71924100 @default.
• W2103606437 hasConcept C86803240 @default.
• W2103606437 hasConceptScore W2103606437C142462285 @default.
• W2103606437 hasConceptScore W2103606437C147483822 @default.
• W2103606437 hasConceptScore W2103606437C157585117 @default.
• W2103606437 hasConceptScore W2103606437C159047783 @default.
• W2103606437 hasConceptScore W2103606437C16005928 @default.
• W2103606437 hasConceptScore W2103606437C177713679 @default.
• W2103606437 hasConceptScore W2103606437C203014093 @default.
• W2103606437 hasConceptScore W2103606437C2779548794 @default.
• W2103606437 hasConceptScore W2103606437C2909254382 @default.
• W2103606437 hasConceptScore W2103606437C2993143319 @default.
• W2103606437 hasConceptScore W2103606437C3013748606 @default.
• W2103606437 hasConceptScore W2103606437C3019165603 @default.
• W2103606437 hasConceptScore W2103606437C60644358 @default.
• W2103606437 hasConceptScore W2103606437C71924100 @default.
• W2103606437 hasConceptScore W2103606437C86803240 @default.
• W2103606437 hasIssue "07" @default.
• W2103606437 hasLocation W21036064371 @default.
• W2103606437 hasOpenAccess W2103606437 @default.
• W2103606437 hasPrimaryLocation W21036064371 @default.
• W2103606437 hasRelatedWork W1693997567 @default.
• W2103606437 hasRelatedWork W2046386873 @default.
• W2103606437 hasRelatedWork W2104525569 @default.
• W2103606437 hasRelatedWork W2157738683 @default.
• W2103606437 hasRelatedWork W2404133416 @default.
• W2103606437 hasRelatedWork W2418227611 @default.
• W2103606437 hasRelatedWork W2473570102 @default.
• W2103606437 hasRelatedWork W2594359367 @default.
• W2103606437 hasRelatedWork W3163569494 @default.
• W2103606437 hasRelatedWork W4255610595 @default.
• W2103606437 hasVolume "04" @default.
• W2103606437 isParatext "false" @default.
• W2103606437 isRetracted "false" @default.
• W2103606437 magId "2103606437" @default.
• W2103606437 workType "article" @default.