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- W2103608257 abstract "Platelets play a central role in hemostasis, but also in atherothrombosis, as they rapidly adhere to tissue and to one another as a response to any vascular injury. This process involves a large number of surface receptors, signaling pathways, and enzymatic cascades as well as their complex interplay. Although in vitro experiments proved successful in both identifying new receptors and pathways and developing potent and selective antithrombotic drugs, in vitro research cannot mimic the myriad hemodynamic and spatiotemporal cellular and molecular interactions that occur during the generation and propagation of thrombi in vivo. Animal models, and, with the availability of genetically modified mouse strains and of modern intravital imaging techniques, mouse models in particular, have opened new ways to identify both individual roles and the interplay of platelet proteins in complex in vivo settings. In vivo models revealed the important role of, eg, Gas6 or blood coagulation factor XII in thrombus formation, and results obtained in in vivo models raised the interesting possibility that (physiologic) hemostasis and (pathologic) thrombosis might represent 2 mechanistically different processes. This review summarizes in vivo findings that contributed significantly to our understanding of hemostatic and thrombotic processes and which may help to guide future research." @default.
- W2103608257 created "2016-06-24" @default.
- W2103608257 creator A5008888080 @default.
- W2103608257 creator A5012568958 @default.
- W2103608257 date "2007-04-13" @default.
- W2103608257 modified "2023-09-30" @default.
- W2103608257 title "In Vivo Thrombus Formation in Murine Models" @default.
- W2103608257 cites W101862950 @default.
- W2103608257 cites W1480134646 @default.
- W2103608257 cites W1525378600 @default.
- W2103608257 cites W1531273705 @default.
- W2103608257 cites W1536015903 @default.
- W2103608257 cites W1543884598 @default.
- W2103608257 cites W1567363998 @default.
- W2103608257 cites W1574213882 @default.
- W2103608257 cites W1605902218 @default.
- W2103608257 cites W1608256683 @default.
- W2103608257 cites W1657825487 @default.
- W2103608257 cites W1658287483 @default.
- W2103608257 cites W1707922975 @default.
- W2103608257 cites W1743894323 @default.
- W2103608257 cites W1892723216 @default.
- W2103608257 cites W1897252591 @default.
- W2103608257 cites W1919102519 @default.
- W2103608257 cites W1936995585 @default.
- W2103608257 cites W1965740748 @default.
- W2103608257 cites W1967534082 @default.
- W2103608257 cites W1971309654 @default.
- W2103608257 cites W1972832497 @default.
- W2103608257 cites W1973043594 @default.
- W2103608257 cites W1974146559 @default.
- W2103608257 cites W1974882457 @default.
- W2103608257 cites W1982309326 @default.
- W2103608257 cites W1982733325 @default.
- W2103608257 cites W1985975297 @default.
- W2103608257 cites W1986747192 @default.
- W2103608257 cites W1999927753 @default.
- W2103608257 cites W2000312990 @default.
- W2103608257 cites W2004761712 @default.
- W2103608257 cites W2008184120 @default.
- W2103608257 cites W2013559225 @default.
- W2103608257 cites W2013847077 @default.
- W2103608257 cites W2016217548 @default.
- W2103608257 cites W2016933463 @default.
- W2103608257 cites W2022851623 @default.
- W2103608257 cites W2023122926 @default.
- W2103608257 cites W2025015037 @default.
- W2103608257 cites W2025166282 @default.
- W2103608257 cites W2029004784 @default.
- W2103608257 cites W2029271892 @default.
- W2103608257 cites W2030455963 @default.
- W2103608257 cites W2033035657 @default.
- W2103608257 cites W2036655503 @default.
- W2103608257 cites W2038469874 @default.
- W2103608257 cites W2039848332 @default.
- W2103608257 cites W2040032861 @default.
- W2103608257 cites W2045676822 @default.
- W2103608257 cites W2046499889 @default.
- W2103608257 cites W2046737719 @default.
- W2103608257 cites W2046809665 @default.
- W2103608257 cites W2047800110 @default.
- W2103608257 cites W2053965071 @default.
- W2103608257 cites W2054540030 @default.
- W2103608257 cites W2056480338 @default.
- W2103608257 cites W2056587965 @default.
- W2103608257 cites W2057410086 @default.
- W2103608257 cites W2061344749 @default.
- W2103608257 cites W2062563200 @default.
- W2103608257 cites W2067235985 @default.
- W2103608257 cites W2070368409 @default.
- W2103608257 cites W2072299517 @default.
- W2103608257 cites W2072629623 @default.
- W2103608257 cites W2074504036 @default.
- W2103608257 cites W2074707530 @default.
- W2103608257 cites W2075018860 @default.
- W2103608257 cites W2076244069 @default.
- W2103608257 cites W2077290326 @default.
- W2103608257 cites W2080226094 @default.
- W2103608257 cites W2080525854 @default.
- W2103608257 cites W2084289450 @default.
- W2103608257 cites W2085727695 @default.
- W2103608257 cites W2086917915 @default.
- W2103608257 cites W2087411946 @default.
- W2103608257 cites W2090451941 @default.
- W2103608257 cites W2092330685 @default.
- W2103608257 cites W2100021081 @default.
- W2103608257 cites W2100712701 @default.
- W2103608257 cites W2107916818 @default.
- W2103608257 cites W2114278146 @default.
- W2103608257 cites W2120595618 @default.
- W2103608257 cites W2124989653 @default.
- W2103608257 cites W2126683943 @default.
- W2103608257 cites W2128214001 @default.
- W2103608257 cites W2129464080 @default.
- W2103608257 cites W2129958400 @default.
- W2103608257 cites W2130083671 @default.
- W2103608257 cites W2131058877 @default.
- W2103608257 cites W2134723230 @default.