Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103609042> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2103609042 endingPage "1617" @default.
- W2103609042 startingPage "1610" @default.
- W2103609042 abstract "Many ChIP-Seq experiments are aimed at developing gold standards for determining the locations of various genomic features such as transcription start or transcription factor binding sites on the whole genome. Many such pioneering experiments lack rigorous testing methods and adequate 'gold standard' annotations to compare against as they themselves are the most reliable source of empirical data available. To overcome this problem, we propose a self-consistency test whereby a dataset is tested against itself. It relies on a supervised machine learning style protocol for in silico annotation of a genome and accuracy estimation to guarantee, at least, self-consistency.The main results use a novel performance metric (a calibrated precision) in order to assess and compare the robustness of the proposed supervised learning method across different test sets. As a proof of principle, we applied the whole protocol to two recent ChIP-Seq ENCODE datasets of STAT1 and Pol-II binding sites. STAT1 is benchmarked against in silicodetection of binding sites using available position weight matrices. Pol-II, the main focus of this paper, is benchmarked against 17 algorithms for the closely related and well-studied problem of in silico transcription start site (TSS) prediction. Our results also demonstrate the feasibility of in silico genome annotation extension with encouraging results from a small portion of annotated genome to the remainder.Available fromhttp://www.genomics.csse.unimelb.edu.au/gat." @default.
- W2103609042 created "2016-06-24" @default.
- W2103609042 creator A5029760705 @default.
- W2103609042 creator A5064626077 @default.
- W2103609042 date "2011-05-09" @default.
- W2103609042 modified "2023-10-18" @default.
- W2103609042 title "Genome annotation test with validation on transcription start site and ChIP-Seq for Pol-II binding data" @default.
- W2103609042 cites W1965100590 @default.
- W2103609042 cites W1976526581 @default.
- W2103609042 cites W1996212302 @default.
- W2103609042 cites W2003463914 @default.
- W2103609042 cites W2011064727 @default.
- W2103609042 cites W2049569197 @default.
- W2103609042 cites W2049970533 @default.
- W2103609042 cites W2099961908 @default.
- W2103609042 cites W2105089812 @default.
- W2103609042 cites W2105776281 @default.
- W2103609042 cites W2111400482 @default.
- W2103609042 cites W2123231299 @default.
- W2103609042 cites W2130410032 @default.
- W2103609042 cites W2140948028 @default.
- W2103609042 cites W2142976423 @default.
- W2103609042 cites W2152100019 @default.
- W2103609042 cites W2157825442 @default.
- W2103609042 cites W2166971561 @default.
- W2103609042 doi "https://doi.org/10.1093/bioinformatics/btr263" @default.
- W2103609042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21558156" @default.
- W2103609042 hasPublicationYear "2011" @default.
- W2103609042 type Work @default.
- W2103609042 sameAs 2103609042 @default.
- W2103609042 citedByCount "0" @default.
- W2103609042 crossrefType "journal-article" @default.
- W2103609042 hasAuthorship W2103609042A5029760705 @default.
- W2103609042 hasAuthorship W2103609042A5064626077 @default.
- W2103609042 hasBestOaLocation W21036090421 @default.
- W2103609042 hasConcept C104317684 @default.
- W2103609042 hasConcept C124101348 @default.
- W2103609042 hasConcept C141231307 @default.
- W2103609042 hasConcept C154945302 @default.
- W2103609042 hasConcept C189206191 @default.
- W2103609042 hasConcept C2775905019 @default.
- W2103609042 hasConcept C2776321320 @default.
- W2103609042 hasConcept C41008148 @default.
- W2103609042 hasConcept C54355233 @default.
- W2103609042 hasConcept C66746571 @default.
- W2103609042 hasConcept C70721500 @default.
- W2103609042 hasConcept C86803240 @default.
- W2103609042 hasConcept C89566754 @default.
- W2103609042 hasConceptScore W2103609042C104317684 @default.
- W2103609042 hasConceptScore W2103609042C124101348 @default.
- W2103609042 hasConceptScore W2103609042C141231307 @default.
- W2103609042 hasConceptScore W2103609042C154945302 @default.
- W2103609042 hasConceptScore W2103609042C189206191 @default.
- W2103609042 hasConceptScore W2103609042C2775905019 @default.
- W2103609042 hasConceptScore W2103609042C2776321320 @default.
- W2103609042 hasConceptScore W2103609042C41008148 @default.
- W2103609042 hasConceptScore W2103609042C54355233 @default.
- W2103609042 hasConceptScore W2103609042C66746571 @default.
- W2103609042 hasConceptScore W2103609042C70721500 @default.
- W2103609042 hasConceptScore W2103609042C86803240 @default.
- W2103609042 hasConceptScore W2103609042C89566754 @default.
- W2103609042 hasIssue "12" @default.
- W2103609042 hasLocation W21036090421 @default.
- W2103609042 hasLocation W21036090422 @default.
- W2103609042 hasOpenAccess W2103609042 @default.
- W2103609042 hasPrimaryLocation W21036090421 @default.
- W2103609042 hasRelatedWork W110079389 @default.
- W2103609042 hasRelatedWork W142583359 @default.
- W2103609042 hasRelatedWork W1976142521 @default.
- W2103609042 hasRelatedWork W2047016028 @default.
- W2103609042 hasRelatedWork W2063853667 @default.
- W2103609042 hasRelatedWork W2079600570 @default.
- W2103609042 hasRelatedWork W2135993011 @default.
- W2103609042 hasRelatedWork W2319942811 @default.
- W2103609042 hasRelatedWork W2497609083 @default.
- W2103609042 hasRelatedWork W2957309664 @default.
- W2103609042 hasVolume "27" @default.
- W2103609042 isParatext "false" @default.
- W2103609042 isRetracted "false" @default.
- W2103609042 magId "2103609042" @default.
- W2103609042 workType "article" @default.