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- W2103609985 abstract "Arylsulfonyl analogs of aminopyrimidines (e.g. Ro 04-6790; 2), aminopyridines (e.g. Ro 63-0563; 3), 1-phenylpiperazines (e.g. SB-271046; 4), and tryptamines (e.g. MS-245; 5) were described as the first examples of selective 5-HT(6) receptor antagonists only ten years ago. Today, hundreds of compounds of seemingly diverse structure have been reported. The early antagonists featured an arylsulfonyl group leading to the wide notspread assumption that an arylsulfonyl moiety might be critical for binding and antagonist action. With respect to the arylsulfonyltryptamines, it seems that neither the arylsulfonyl nor the tryptamine portion of these compounds is essential for binding or for antagonist action, and some such derivatives even display agonist action. The present review describes many of the currently available 5-HT(6) receptor ligands and, unlike prior reviews, provides a narrative of the thinking (where possible) that led to their design, synthesis, and evaluation. The arylsulfonyltryptamines are also used as the structural basis of attempts to relate various structure-types to one another to afford a better understanding of the overall structural requirements for 5-HT(6) receptor binding." @default.
- W2103609985 created "2016-06-24" @default.
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- W2103609985 date "2010-04-01" @default.
- W2103609985 modified "2023-10-03" @default.
- W2103609985 title "The Medicinal Chemistry of 5-HT6 Receptor Ligands with a Focus on Arylsulfonyltryptamine Analogs" @default.
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- W2103609985 cites W2016955117 @default.
- W2103609985 cites W2022514673 @default.
- W2103609985 cites W2022926817 @default.
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- W2103609985 cites W2038101767 @default.
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- W2103609985 doi "https://doi.org/10.2174/156802610791111542" @default.
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