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- W2103621568 abstract "Abstract The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited altered expression. Consistent with this finding, Oct-1-deficient fibroblasts were hypersensitive to γ radiation, doxorubicin, and hydrogen peroxide and harbored elevated reactive oxygen species. Expression profiling identified a second group of genes dysregulated in Oct-1-deficient fibroblasts following irradiation, including many associated with oxidative and metabolic stress. A number of these genes contain octamer sequences in their immediate 5′ regulatory regions, some of which are conserved in human. These results indicate that Oct-1 modulates the activity of genes important for the cellular response to stress." @default.
- W2103621568 created "2016-06-24" @default.
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- W2103621568 date "2005-12-01" @default.
- W2103621568 modified "2023-10-17" @default.
- W2103621568 title "The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor" @default.
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- W2103621568 doi "https://doi.org/10.1158/0008-5472.can-05-2399" @default.
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