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• W2103631252 abstract "Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1α, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as a possible therapeutic target for Parkinson's disease, with important roles in the function and survival of dopaminergic neurons in the substantia nigra. The objective of this study is to determine if the loss of PGC-1α activity contributes to α-synuclein-induced degeneration.We explore the vulnerability of PGC-1α null mice to the accumulation of human α-synuclein in nigral neurons, and assess the neuroprotective effect of AAV-mediated PGC-1α expression in this experimental model. Using neuronal cultures derived from these mice, mitochondrial respiration and production of reactive oxygen species are assessed in conditions of human α-synuclein overexpression. We find ultrastructural evidence for abnormal mitochondria and fragmented endoplasmic reticulum in the nigral dopaminergic neurons of PGC-1α null mice. Furthermore, PGC-1α null nigral neurons are more prone to degenerate following overexpression of human α-synuclein, an effect more apparent in male mice. PGC-1α overexpression restores mitochondrial morphology, oxidative stress detoxification and basal respiration, which is consistent with the observed neuroprotection against α-synuclein toxicity in male PGC-1α null mice.Altogether, our results highlight an important role for PGC-1α in controlling the mitochondrial function of nigral neurons accumulating α-synuclein, which may be critical for gender-dependent vulnerability to Parkinson's disease." @default.
• W2103631252 created "2016-06-24" @default.
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• W2103631252 date "2015-04-01" @default.
• W2103631252 modified "2023-10-18" @default.
• W2103631252 title "PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein" @default.
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• W2103631252 cites W1505478984 @default.
• W2103631252 cites W1538904872 @default.
• W2103631252 cites W1545110321 @default.
• W2103631252 cites W1877873625 @default.
• W2103631252 cites W1903704021 @default.
• W2103631252 cites W1950372811 @default.
• W2103631252 cites W1964739304 @default.
• W2103631252 cites W1966985989 @default.
• W2103631252 cites W1969800514 @default.
• W2103631252 cites W1970065788 @default.
• W2103631252 cites W1975488633 @default.
• W2103631252 cites W1976072714 @default.
• W2103631252 cites W1977339956 @default.
• W2103631252 cites W1978900128 @default.
• W2103631252 cites W1980962724 @default.
• W2103631252 cites W1981049765 @default.
• W2103631252 cites W1982557547 @default.
• W2103631252 cites W1992241406 @default.
• W2103631252 cites W1992371392 @default.
• W2103631252 cites W1995354490 @default.
• W2103631252 cites W1999566059 @default.
• W2103631252 cites W2005379429 @default.
• W2103631252 cites W2006148647 @default.
• W2103631252 cites W2008748100 @default.
• W2103631252 cites W2015784694 @default.
• W2103631252 cites W2015932693 @default.
• W2103631252 cites W2018427433 @default.
• W2103631252 cites W2024215142 @default.
• W2103631252 cites W2029879331 @default.
• W2103631252 cites W2033832481 @default.
• W2103631252 cites W2035787181 @default.
• W2103631252 cites W2037640340 @default.
• W2103631252 cites W2049613365 @default.
• W2103631252 cites W2051964908 @default.
• W2103631252 cites W2053569048 @default.
• W2103631252 cites W2055029031 @default.
• W2103631252 cites W2055902281 @default.
• W2103631252 cites W2060556723 @default.
• W2103631252 cites W2064230441 @default.
• W2103631252 cites W2071540209 @default.
• W2103631252 cites W2074974240 @default.
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• W2103631252 cites W2084543989 @default.
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• W2103631252 cites W2088231371 @default.
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• W2103631252 doi "https://doi.org/10.1186/s40478-015-0200-8" @default.
• W2103631252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4379693" @default.
• W2103631252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25853296" @default.
• W2103631252 hasPublicationYear "2015" @default.
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