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- W2103640990 abstract "Signaling through the Notch pathway controls cell growth and differentiation in metazoans. Following binding of its ligands, the intracellular part of the cell surface Notch1 receptor (Notch1-IC) is released and translocates to the nucleus, where it alters the function of the DNA-binding transcription factor CBF1/RBP-Jκ. As a result, CBF1/RBP-Jκ is converted from a repressor to an activator of gene transcription. Similarly, the Epstein Barr viral oncoprotein EBNA2, which is required for B-cell immortalization, activates genes through CBF1. Moreover, the TAN-1 and int-3 oncogenes represent activated versions of Notch1 and Notch4, respectively. Here, we show that the adenoviral oncoprotein 13S E1A also binds to CBF1/RBP-Jκ, displaces associated corepressor complexes, and activates CBF1/RBP-Jκ–dependent gene expression. Our results suggest that the central role of the Notch–CBF1/RBP-Jκ signaling pathway in cell fate decisions renders it susceptible to pathways of viral replication and oncogenic conversion." @default.
- W2103640990 created "2016-06-24" @default.
- W2103640990 creator A5009791569 @default.
- W2103640990 creator A5039723975 @default.
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- W2103640990 date "2001-02-15" @default.
- W2103640990 modified "2023-10-09" @default.
- W2103640990 title "Activation of the Notch-regulated transcription factor CBF1/RBP-Jκ through the 13SE1A oncoprotein" @default.
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- W2103640990 doi "https://doi.org/10.1101/gad.189301" @default.
- W2103640990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/312632" @default.
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