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• W2103646786 abstract "Chromosomes are replicated in characteristic, temporal patterns during S phase. We have compared the timing of association of replication proteins at early- and late-replicating origins of replication. Minichromosome maintenance proteins assemble simultaneously at early- and late-replicating origins. In contrast, Cdc45p association with late origins is delayed relative to early origins. DNA polymerase α association is similarly delayed at late origins and requires Cdc45p function. Activation of the S phase checkpoint inhibits association of Cdc45p with late-firing origins. These studies suggest that Cdc45p is poised to serve as a key regulatory target for both the temporal and checkpoint-mediated regulation of replication origins." @default.
• W2103646786 created "2016-06-24" @default.
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• W2103646786 date "1999-08-03" @default.
• W2103646786 modified "2023-09-26" @default.
• W2103646786 title "Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication" @default.
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• W2103646786 doi "https://doi.org/10.1073/pnas.96.16.9130" @default.
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