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• W2103646918 abstract "A central challenge in systems biology and medical genetics is to understand how interactions among genetic loci contribute to complex phenotypic traits and human diseases. While most studies have so far relied on statistical modeling and association testing procedures, machine learning and predictive modeling approaches are increasingly being applied to mining genotype-phenotype relationships, also among those associations that do not necessarily meet statistical significance at the level of individual variants, yet still contributing to the combined predictive power at the level of variant panels. Network-based analysis of genetic variants and their interaction partners is another emerging trend by which to explore how sub-network level features contribute to complex disease processes and related phenotypes. In this review, we describe the basic concepts and algorithms behind machine learning-based genetic feature selection approaches, their potential benefits and limitations in genome-wide setting, and how physical or genetic interaction networks could be used as a priori information for providing improved predictive power and mechanistic insights into the disease networks. These developments are geared toward explaining a part of the missing heritability, and when combined with individual genomic profiling, such systems medicine approaches may also provide a principled means for tailoring personalized treatment strategies in the future." @default.
• W2103646918 created "2016-06-24" @default.
• W2103646918 creator A5016681267 @default.
• W2103646918 creator A5021993986 @default.
• W2103646918 creator A5045285235 @default.
• W2103646918 date "2013-03-01" @default.
• W2103646918 modified "2023-10-10" @default.
• W2103646918 title "Genetic variants and their interactions in disease risk prediction – machine learning and network perspectives" @default.
• W2103646918 cites W1559923427 @default.
• W2103646918 cites W180744188 @default.
• W2103646918 cites W1965302838 @default.
• W2103646918 cites W1966182052 @default.
• W2103646918 cites W1973778908 @default.
• W2103646918 cites W1975387345 @default.
• W2103646918 cites W1975990737 @default.
• W2103646918 cites W1987620105 @default.
• W2103646918 cites W1989531990 @default.
• W2103646918 cites W1989706328 @default.
• W2103646918 cites W1992045522 @default.
• W2103646918 cites W1992062845 @default.
• W2103646918 cites W1992140675 @default.
• W2103646918 cites W1992250714 @default.
• W2103646918 cites W1998003466 @default.
• W2103646918 cites W2003747371 @default.
• W2103646918 cites W2006631099 @default.
• W2103646918 cites W2007733142 @default.
• W2103646918 cites W2007807048 @default.
• W2103646918 cites W2008523512 @default.
• W2103646918 cites W2009405916 @default.
• W2103646918 cites W2011671834 @default.
• W2103646918 cites W2012280706 @default.
• W2103646918 cites W2014584925 @default.
• W2103646918 cites W2015578131 @default.
• W2103646918 cites W2017289276 @default.
• W2103646918 cites W2019483502 @default.
• W2103646918 cites W2020427316 @default.
• W2103646918 cites W2026300665 @default.
• W2103646918 cites W2026475293 @default.
• W2103646918 cites W2028673142 @default.
• W2103646918 cites W2030628077 @default.
• W2103646918 cites W2033591223 @default.
• W2103646918 cites W2038689886 @default.
• W2103646918 cites W2041448690 @default.
• W2103646918 cites W2042308063 @default.
• W2103646918 cites W2043235003 @default.
• W2103646918 cites W2046434400 @default.
• W2103646918 cites W2047031939 @default.
• W2103646918 cites W2047066646 @default.
• W2103646918 cites W2050086663 @default.
• W2103646918 cites W2052771399 @default.
• W2103646918 cites W2053746068 @default.
• W2103646918 cites W2053900484 @default.
• W2103646918 cites W2054885243 @default.
• W2103646918 cites W2056455811 @default.
• W2103646918 cites W2060130700 @default.
• W2103646918 cites W2061771504 @default.
• W2103646918 cites W2062533676 @default.
• W2103646918 cites W2063575312 @default.
• W2103646918 cites W2064615756 @default.
• W2103646918 cites W2068434665 @default.
• W2103646918 cites W2070082005 @default.
• W2103646918 cites W2072664252 @default.
• W2103646918 cites W2076011171 @default.
• W2103646918 cites W2078444181 @default.
• W2103646918 cites W2085060592 @default.
• W2103646918 cites W2086753644 @default.
• W2103646918 cites W2088586179 @default.
• W2103646918 cites W2091806847 @default.
• W2103646918 cites W2094189284 @default.
• W2103646918 cites W2097099463 @default.
• W2103646918 cites W2097948046 @default.
• W2103646918 cites W2103184242 @default.
• W2103646918 cites W2103342342 @default.
• W2103646918 cites W2107956883 @default.
• W2103646918 cites W2108172198 @default.
• W2103646918 cites W2108420460 @default.
• W2103646918 cites W2110137821 @default.
• W2103646918 cites W2110745807 @default.
• W2103646918 cites W2110808585 @default.
• W2103646918 cites W2111842731 @default.
• W2103646918 cites W2112917490 @default.
• W2103646918 cites W2113244577 @default.
• W2103646918 cites W2114256688 @default.
• W2103646918 cites W2115718427 @default.
• W2103646918 cites W2119387367 @default.
• W2103646918 cites W2120051475 @default.
• W2103646918 cites W2121514846 @default.
• W2103646918 cites W2122189635 @default.
• W2103646918 cites W2122630333 @default.
• W2103646918 cites W2125419286 @default.
• W2103646918 cites W2128292008 @default.
• W2103646918 cites W2130856032 @default.
• W2103646918 cites W2131811731 @default.
• W2103646918 cites W2131822674 @default.
• W2103646918 cites W2133395891 @default.
• W2103646918 cites W2133465414 @default.
• W2103646918 cites W2134783591 @default.
• W2103646918 cites W2135107356 @default.
• W2103646918 cites W2137249087 @default.
• W2103646918 cites W2138470019 @default.

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