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- W2103648640 abstract "Populations of Schofield strain, random-bred mice were shown to have a bimodal variation in ability to bring about immune expulsion of the nematode Trichuris muris . This variation was genetically determined and independent of the size of infection experienced. The proportion of mice unable to achieve worm expulsion (non-responders) was relatively constant in various populations of the strain but was increased by selective breeding from mice of known status. Crosses made between non-responder and responder mice produced progeny that were almost all (92%) of responder phenotype, showing that the ability to achieve worm expulsion was inherited as a dominant characteristic. It is suggested that the genetic control involves a small number of genes; the possible immunological mechanisms by which control is mediated are briefly discussed." @default.
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- W2103648640 date "1975-12-01" @default.
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- W2103648640 title "Genetic control of immune responses to parasites: selection for responsiveness and non-responsiveness to <i>Trichuris muris</i> in random-bred mice" @default.
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- W2103648640 doi "https://doi.org/10.1017/s0031182000047156" @default.
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