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- W2103662487 abstract "Whether a strain of methicillin-resistant Staphylococcus aureus susceptible to cephalothin by the disk-diffusion method was also susceptible to cephalothin in vivo was evaluated in the rabbit model of endocarditis. Rabbits with aortic-valve endocarditis due to methicillin-resistant S. aureus that were treated for four days with cephalothin had the same numbers of organisms in vegetations as did untreated rabbits. Treatment with cephalothin caused emergence of a highly resistant subpopulation in aortic-valve vegetations. Organisms highly resistant to cephalothin were also highly resistant to nafcillin. Thus broth-dilution and disk-diffusion tests may not predict therapeutic failure for cephalothin against strains of methicillin-resistant S. aureus. Because of cross-resistances among beta-lactam drugs, these strains should be considered uniformly resistant to this general class of antimicrobial agents, regardless of results from these tests." @default.
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- W2103662487 date "1984-06-01" @default.
- W2103662487 modified "2023-10-14" @default.
- W2103662487 title "Endocarditis Due to Methicillin-Resistant Staphylococcus aureus in Rabbits: Expression of Resistance to -Lactam Antibiotics in Vivo and in Vitro" @default.
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- W2103662487 doi "https://doi.org/10.1093/infdis/149.6.894" @default.
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