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• W2103665811 endingPage "989" @default.
• W2103665811 startingPage "981" @default.
• W2103665811 abstract "Abstract Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a group of targeted anticancer agents. The first of these new HDACi, vorinostat (suberoylanilide hydroxamic acid), has received Food and Drug Administration approval for treating patients with cutaneous T-cell lymphoma. This review focuses on the activities of the 11 zinc-containing HDACs, their histone and nonhistone protein substrates, and the different pathways by which HDACi induce transformed cell death. A hypothesis is presented to explain the relative resistance of normal cells to HDACi-induced cell death. (Mol Cancer Res 2007;5(10):981–9)" @default.
• W2103665811 created "2016-06-24" @default.
• W2103665811 creator A5015606024 @default.
• W2103665811 creator A5062949690 @default.
• W2103665811 creator A5078159824 @default.
• W2103665811 date "2007-10-01" @default.
• W2103665811 modified "2023-10-07" @default.
• W2103665811 title "Histone Deacetylase Inhibitors: Overview and Perspectives" @default.
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