Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103667597> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2103667597 endingPage "S663" @default.
- W2103667597 startingPage "S663" @default.
- W2103667597 abstract "This study aims to investigate the feasibility and utility of serial magnetic resonance imaging (MRI) to guide the design, delivery and evaluation of a murine intracranial (IC) tumor experiment of radiation (RT) and anti-angiogenic (AA) therapy. U87 glioma cells were injected IC into 58 NOD SCID mice. Serial MRI with gadolinium via tail vein were acquired at day 0 (7days post-IC), and days 3,7,10,14 and 21. Mice with MRI visible tumors at day 0 were stratified by tumor size to:(1) placebo (CTRL) (2) RT+placebo (RT) (3) Sunitinib (SU) (4) RT+SU (SURT). Day 0 MRI tumor-targeted and cone-beam CT (CBCT) guided RT was used to deliver 8Gy on day 1. SU 0.8mg or placebo was given via oral gavage for 7 days starting day 1. MRI evaluation included: (1) T2-weighted (2) Quantitative T1 (3) Dynamic contrast-enhanced (DCE) (4) Diffusion weighted (DWI) (5) T1-weighted with gadolinium. RT dose to each tumor was evaluated on fused images of CBCT and day 0 MRI. Fifty-two mice with visible tumors were assigned to treatment arms to ensure similar baseline tumor volumes for all arms: 0.60±0.04mm3 [Range: 0.09-1.6mm3]. No mice expired with serial imaging. All irradiated tumors received >90% prescribed dose. Tumor growth rate was better for SU+RT than placebo (p<0.001) or SU (p = 0.003) but was similar between RT and SU+RT (p = 0.4). By day 3, DCE (iAUC60) decreased in SU+RT 31±7% but increased in CTRL16±1% (p = 0.00009), RT 34±16% (p = 0.0008), and SU15±8% (p = 0.0004). Rise from baseline in %ADC(tumor/normal brain) became significantly greater by day10 for SURT and RT arms (22%, p = 0.01) but not for SU (12%, p = 0.9) vs. CTRL 11%. This study demonstrates serial MRI studies are feasible and augments investigation of RT and AA in murine IC tumor models by providing temporal, spatial and physiological information. Serial MRI allowed identification of promising biomarkers and their optimal timing: statistically significant decline in iAUC60 at day 3 and rise in ADC by day 10. This data will guide future preclinical studies to evaluate the underlying pathophysiology and timing of clinical imaging for biomarker evaluations." @default.
- W2103667597 created "2016-06-24" @default.
- W2103667597 creator A5007768293 @default.
- W2103667597 creator A5020081418 @default.
- W2103667597 creator A5027517037 @default.
- W2103667597 creator A5036663495 @default.
- W2103667597 creator A5038132399 @default.
- W2103667597 creator A5038233199 @default.
- W2103667597 creator A5059332930 @default.
- W2103667597 creator A5063182563 @default.
- W2103667597 creator A5072584423 @default.
- W2103667597 creator A5076563668 @default.
- W2103667597 date "2010-11-01" @default.
- W2103667597 modified "2023-09-27" @default.
- W2103667597 title "Intracranial Murine Tumor Investigation of Radiation and Antiangiogenic Agents using Serial MRI" @default.
- W2103667597 doi "https://doi.org/10.1016/j.ijrobp.2010.07.1543" @default.
- W2103667597 hasPublicationYear "2010" @default.
- W2103667597 type Work @default.
- W2103667597 sameAs 2103667597 @default.
- W2103667597 citedByCount "0" @default.
- W2103667597 crossrefType "journal-article" @default.
- W2103667597 hasAuthorship W2103667597A5007768293 @default.
- W2103667597 hasAuthorship W2103667597A5020081418 @default.
- W2103667597 hasAuthorship W2103667597A5027517037 @default.
- W2103667597 hasAuthorship W2103667597A5036663495 @default.
- W2103667597 hasAuthorship W2103667597A5038132399 @default.
- W2103667597 hasAuthorship W2103667597A5038233199 @default.
- W2103667597 hasAuthorship W2103667597A5059332930 @default.
- W2103667597 hasAuthorship W2103667597A5063182563 @default.
- W2103667597 hasAuthorship W2103667597A5072584423 @default.
- W2103667597 hasAuthorship W2103667597A5076563668 @default.
- W2103667597 hasBestOaLocation W21036675971 @default.
- W2103667597 hasConcept C121608353 @default.
- W2103667597 hasConcept C126322002 @default.
- W2103667597 hasConcept C126838900 @default.
- W2103667597 hasConcept C142724271 @default.
- W2103667597 hasConcept C143409427 @default.
- W2103667597 hasConcept C191897082 @default.
- W2103667597 hasConcept C192562407 @default.
- W2103667597 hasConcept C204787440 @default.
- W2103667597 hasConcept C27081682 @default.
- W2103667597 hasConcept C2778227246 @default.
- W2103667597 hasConcept C2779490328 @default.
- W2103667597 hasConcept C2989005 @default.
- W2103667597 hasConcept C502942594 @default.
- W2103667597 hasConcept C509974204 @default.
- W2103667597 hasConcept C557651011 @default.
- W2103667597 hasConcept C71924100 @default.
- W2103667597 hasConceptScore W2103667597C121608353 @default.
- W2103667597 hasConceptScore W2103667597C126322002 @default.
- W2103667597 hasConceptScore W2103667597C126838900 @default.
- W2103667597 hasConceptScore W2103667597C142724271 @default.
- W2103667597 hasConceptScore W2103667597C143409427 @default.
- W2103667597 hasConceptScore W2103667597C191897082 @default.
- W2103667597 hasConceptScore W2103667597C192562407 @default.
- W2103667597 hasConceptScore W2103667597C204787440 @default.
- W2103667597 hasConceptScore W2103667597C27081682 @default.
- W2103667597 hasConceptScore W2103667597C2778227246 @default.
- W2103667597 hasConceptScore W2103667597C2779490328 @default.
- W2103667597 hasConceptScore W2103667597C2989005 @default.
- W2103667597 hasConceptScore W2103667597C502942594 @default.
- W2103667597 hasConceptScore W2103667597C509974204 @default.
- W2103667597 hasConceptScore W2103667597C557651011 @default.
- W2103667597 hasConceptScore W2103667597C71924100 @default.
- W2103667597 hasIssue "3" @default.
- W2103667597 hasLocation W21036675971 @default.
- W2103667597 hasOpenAccess W2103667597 @default.
- W2103667597 hasPrimaryLocation W21036675971 @default.
- W2103667597 hasRelatedWork W1549480055 @default.
- W2103667597 hasRelatedWork W1967287397 @default.
- W2103667597 hasRelatedWork W1970558757 @default.
- W2103667597 hasRelatedWork W2021884865 @default.
- W2103667597 hasRelatedWork W2084573604 @default.
- W2103667597 hasRelatedWork W2125247442 @default.
- W2103667597 hasRelatedWork W2579165050 @default.
- W2103667597 hasRelatedWork W2801038295 @default.
- W2103667597 hasRelatedWork W2913624518 @default.
- W2103667597 hasRelatedWork W3118294176 @default.
- W2103667597 hasVolume "78" @default.
- W2103667597 isParatext "false" @default.
- W2103667597 isRetracted "false" @default.
- W2103667597 magId "2103667597" @default.
- W2103667597 workType "article" @default.