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- W2103668687 abstract "Abstract HPV encoded proteins can elicit ectopic protein–protein interactions that re-wire signaling pathways, in a mode that promotes malignancy. Moreover, accumulating data related to HPV is now providing compelling substantiation of a central role played by HPV in escaping immunosurveillance and impairment of apoptotic response. What emerges is an intricate network of Wnt, TGF, Notch signaling cascades that forms higher-order ligand–receptor complexes routing downstream signaling in HPV infected cells. These HPV infected cells are regulated both extracellularly by ligand receptor axis and intracellularly by HPV encoded proteins and impair TRAIL mediated apoptosis. We divide this review into different sections addressing how linear signaling pathways integrate to facilitate carcinogenesis and compounds that directly or indirectly reverse these aberrant interactions offer new possibilities for therapy in cancer. Although HPV encoded proteins mediated misrepresentation of pathways is difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can target dysregulated pathways in HPV infected cervical cancer cells, thus setting the stage for preclinical models and clinical trials." @default.
- W2103668687 created "2016-06-24" @default.
- W2103668687 creator A5026093939 @default.
- W2103668687 creator A5071619555 @default.
- W2103668687 creator A5073515685 @default.
- W2103668687 date "2013-06-17" @default.
- W2103668687 modified "2023-09-28" @default.
- W2103668687 title "Nip the HPV encoded evil in the cancer bud: HPV reshapes TRAILs and signaling landscapes" @default.
- W2103668687 cites W1546765786 @default.
- W2103668687 cites W1964227091 @default.
- W2103668687 cites W1964273844 @default.
- W2103668687 cites W1964646881 @default.
- W2103668687 cites W1965635324 @default.
- W2103668687 cites W1967639197 @default.
- W2103668687 cites W1968012317 @default.
- W2103668687 cites W1968485762 @default.
- W2103668687 cites W1969816880 @default.
- W2103668687 cites W1969817641 @default.
- W2103668687 cites W1972682884 @default.
- W2103668687 cites W1973180286 @default.
- W2103668687 cites W1973822547 @default.
- W2103668687 cites W1974313884 @default.
- W2103668687 cites W1975486353 @default.
- W2103668687 cites W1976065177 @default.
- W2103668687 cites W1978642446 @default.
- W2103668687 cites W1980388821 @default.
- W2103668687 cites W1980531507 @default.
- W2103668687 cites W1980774083 @default.
- W2103668687 cites W1982193970 @default.
- W2103668687 cites W1982404719 @default.
- W2103668687 cites W1982798128 @default.
- W2103668687 cites W1983023920 @default.
- W2103668687 cites W1983680724 @default.
- W2103668687 cites W1984910916 @default.
- W2103668687 cites W1987109687 @default.
- W2103668687 cites W1987464084 @default.
- W2103668687 cites W1987587918 @default.
- W2103668687 cites W1989320029 @default.
- W2103668687 cites W1990185188 @default.
- W2103668687 cites W1991866963 @default.
- W2103668687 cites W1994151970 @default.
- W2103668687 cites W1995196469 @default.
- W2103668687 cites W1995730318 @default.
- W2103668687 cites W1996082612 @default.
- W2103668687 cites W1998431482 @default.
- W2103668687 cites W2000991672 @default.
- W2103668687 cites W2003281193 @default.
- W2103668687 cites W2006198762 @default.
- W2103668687 cites W2007401297 @default.
- W2103668687 cites W2007704060 @default.
- W2103668687 cites W2008765508 @default.
- W2103668687 cites W2008847855 @default.
- W2103668687 cites W2010003298 @default.
- W2103668687 cites W2010220544 @default.
- W2103668687 cites W2011057188 @default.
- W2103668687 cites W2011363727 @default.
- W2103668687 cites W2012475096 @default.
- W2103668687 cites W2013651529 @default.
- W2103668687 cites W2013809147 @default.
- W2103668687 cites W2015680924 @default.
- W2103668687 cites W2016735382 @default.
- W2103668687 cites W2019903218 @default.
- W2103668687 cites W2020142016 @default.
- W2103668687 cites W2020152109 @default.
- W2103668687 cites W2020371153 @default.
- W2103668687 cites W2023027111 @default.
- W2103668687 cites W2025466551 @default.
- W2103668687 cites W2025749480 @default.
- W2103668687 cites W2025911843 @default.
- W2103668687 cites W2027388324 @default.
- W2103668687 cites W2027477192 @default.
- W2103668687 cites W2030045949 @default.
- W2103668687 cites W2030382851 @default.
- W2103668687 cites W2031431146 @default.
- W2103668687 cites W2034600017 @default.
- W2103668687 cites W2037112275 @default.
- W2103668687 cites W2038139693 @default.
- W2103668687 cites W2038385693 @default.
- W2103668687 cites W2038881876 @default.
- W2103668687 cites W2040560240 @default.
- W2103668687 cites W2041836923 @default.
- W2103668687 cites W2042139236 @default.
- W2103668687 cites W2044542088 @default.
- W2103668687 cites W2046122440 @default.
- W2103668687 cites W2051606353 @default.
- W2103668687 cites W2052538861 @default.
- W2103668687 cites W2052599765 @default.
- W2103668687 cites W2054403197 @default.
- W2103668687 cites W2054533593 @default.
- W2103668687 cites W2055871185 @default.
- W2103668687 cites W2059543660 @default.
- W2103668687 cites W2060804599 @default.
- W2103668687 cites W2062509219 @default.
- W2103668687 cites W2064116640 @default.
- W2103668687 cites W2065410620 @default.
- W2103668687 cites W2066332001 @default.
- W2103668687 cites W2068739236 @default.
- W2103668687 cites W2069489210 @default.
- W2103668687 cites W2070903483 @default.
- W2103668687 cites W2071345969 @default.