FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103669419> ?p ?o ?g. }

• W2103669419 endingPage "282" @default.
• W2103669419 startingPage "273" @default.
• W2103669419 abstract "Sixty‐six consecutive adult patients with acute lymphoblastic leukaemia (ALL) were treated with intensified chemotherapy which included a ‘pre‐induction’ course of cytarabine (AraC) and etoposide (VP16) when the white blood cell count (WBC) was ≥30 × 10 9 /l (18 patients), and maintenance chemotherapy with regular intensifications for a total treatment duration of 3 years. Patients with a mediastinal mass (17) received consolidation courses with intermediate‐dose AraC and VP16 followed by mediastinal irradiation. 11 patients underwent allogeneic bone marrow transplantation in first complete remission (CR). 58 patients (87.9%, CI 77.5–94.6) attained CR; with a median follow‐up of 7 years, 35 of them (60.3%, CI 46.6–73.0) remain in CR. Toxicity was mild, although three patients died during remission induction, including two who were over 70 years of age. 23 patients (39.7%, CI 27.1–53.4) relapsed, seven of them primarily in the central nervous system (CNS), necessitating intensification of CNS‐directed therapy. Only one of 13 patients with WBC 30–100 × 10 9 /l, but eight of nine with WBC >100 × 10 9 /l, relapsed. The survival of older patients in CR did not differ from younger patients. The outcome of ALL in adult patients could thus be improved by slight intensification of treatment whilst keeping the toxicity within acceptable limits. ‘Pre‐induction’ with AraC and VP16 might improve the prognosis, especially in patients with WBC <100 × 10 9 /l. Patients with WBC >100 × 10 9 /l, however, almost always relapse, and the intensified chemotherapy might not be tolerated well by patients over 70 years of age." @default.
• W2103669419 created "2016-06-24" @default.
• W2103669419 creator A5000272305 @default.
• W2103669419 creator A5010075077 @default.
• W2103669419 creator A5046872067 @default.
• W2103669419 creator A5050532707 @default.
• W2103669419 creator A5053651876 @default.
• W2103669419 creator A5062055100 @default.
• W2103669419 creator A5075174309 @default.
• W2103669419 creator A5085873231 @default.
• W2103669419 date "1998-02-01" @default.
• W2103669419 modified "2023-10-17" @default.
• W2103669419 title "Improved outcome of adult acute lymphoblastic leukaemia by moderately intensified chemotherapy which includes a ‘pre-induction’ course for rapid tumour reduction: preliminary results on 66 patients" @default.
• W2103669419 cites W120469029 @default.
• W2103669419 cites W1491154431 @default.
• W2103669419 cites W1582130462 @default.
• W2103669419 cites W1769137098 @default.
• W2103669419 cites W1904414599 @default.
• W2103669419 cites W1905394066 @default.
• W2103669419 cites W1908994222 @default.
• W2103669419 cites W1940961288 @default.
• W2103669419 cites W1981459448 @default.
• W2103669419 cites W198654994 @default.
• W2103669419 cites W2010576366 @default.
• W2103669419 cites W2048732181 @default.
• W2103669419 cites W2053606207 @default.
• W2103669419 cites W2056655605 @default.
• W2103669419 cites W2094705930 @default.
• W2103669419 cites W2116559436 @default.
• W2103669419 cites W2122962750 @default.
• W2103669419 cites W2124011398 @default.
• W2103669419 cites W2138205116 @default.
• W2103669419 cites W2191423525 @default.
• W2103669419 cites W2232468075 @default.
• W2103669419 cites W2263945325 @default.
• W2103669419 cites W2312336641 @default.
• W2103669419 cites W2333611917 @default.
• W2103669419 cites W2335926318 @default.
• W2103669419 cites W2484127286 @default.
• W2103669419 cites W4231961829 @default.
• W2103669419 cites W4246060417 @default.
• W2103669419 cites W4300575106 @default.
• W2103669419 cites W79732601 @default.
• W2103669419 doi "https://doi.org/10.1046/j.1365-2141.1998.00559.x" @default.
• W2103669419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9488613" @default.
• W2103669419 hasPublicationYear "1998" @default.
• W2103669419 type Work @default.
• W2103669419 sameAs 2103669419 @default.
• W2103669419 citedByCount "21" @default.
• W2103669419 countsByYear W21036694192012 @default.
• W2103669419 crossrefType "journal-article" @default.
• W2103669419 hasAuthorship W2103669419A5000272305 @default.
• W2103669419 hasAuthorship W2103669419A5010075077 @default.
• W2103669419 hasAuthorship W2103669419A5046872067 @default.
• W2103669419 hasAuthorship W2103669419A5050532707 @default.
• W2103669419 hasAuthorship W2103669419A5053651876 @default.
• W2103669419 hasAuthorship W2103669419A5062055100 @default.
• W2103669419 hasAuthorship W2103669419A5075174309 @default.
• W2103669419 hasAuthorship W2103669419A5085873231 @default.
• W2103669419 hasConcept C126322002 @default.
• W2103669419 hasConcept C141071460 @default.
• W2103669419 hasConcept C2776611710 @default.
• W2103669419 hasConcept C2776694085 @default.
• W2103669419 hasConcept C2778041864 @default.
• W2103669419 hasConcept C2778119113 @default.
• W2103669419 hasConcept C2778461978 @default.
• W2103669419 hasConcept C2778488018 @default.
• W2103669419 hasConcept C2780007613 @default.
• W2103669419 hasConcept C2781107101 @default.
• W2103669419 hasConcept C2909962599 @default.
• W2103669419 hasConcept C29730261 @default.
• W2103669419 hasConcept C71924100 @default.
• W2103669419 hasConcept C90924648 @default.
• W2103669419 hasConceptScore W2103669419C126322002 @default.
• W2103669419 hasConceptScore W2103669419C141071460 @default.
• W2103669419 hasConceptScore W2103669419C2776611710 @default.
• W2103669419 hasConceptScore W2103669419C2776694085 @default.
• W2103669419 hasConceptScore W2103669419C2778041864 @default.
• W2103669419 hasConceptScore W2103669419C2778119113 @default.
• W2103669419 hasConceptScore W2103669419C2778461978 @default.
• W2103669419 hasConceptScore W2103669419C2778488018 @default.
• W2103669419 hasConceptScore W2103669419C2780007613 @default.
• W2103669419 hasConceptScore W2103669419C2781107101 @default.
• W2103669419 hasConceptScore W2103669419C2909962599 @default.
• W2103669419 hasConceptScore W2103669419C29730261 @default.
• W2103669419 hasConceptScore W2103669419C71924100 @default.
• W2103669419 hasConceptScore W2103669419C90924648 @default.
• W2103669419 hasIssue "2" @default.
• W2103669419 hasLocation W21036694191 @default.
• W2103669419 hasLocation W21036694192 @default.
• W2103669419 hasOpenAccess W2103669419 @default.
• W2103669419 hasPrimaryLocation W21036694191 @default.
• W2103669419 hasRelatedWork W2007442696 @default.
• W2103669419 hasRelatedWork W2027869118 @default.
• W2103669419 hasRelatedWork W2052735722 @default.
• W2103669419 hasRelatedWork W2077634565 @default.
• W2103669419 hasRelatedWork W2087032504 @default.
• W2103669419 hasRelatedWork W2289163431 @default.

• next