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• W2103670349 abstract "Early detection of pancreatic cancer is key to overcoming its poor prognosis. α_vβ₃-integrin is often overexpressed in pancreatic tumor cells, whereas it is scarcely expressed in normal pancreatic cells. In this study, we investigated the usefulness of SPECT imaging with ¹¹¹In-1,4,7,10-tetraazacylododecane-<i>N</i>,<i>N</i>′,<i>N</i>″,<i>N</i>′′′-tetraacetic acid-cyclo-(Arg-Gly-Asp-d-Phe-Lys) [¹¹¹In-DOTA-c(RGDfK)], an imaging probe of α_vβ₃-integrin, for the early detection of pancreatic cancer in a hamster pancreatic carcinogenesis model. <b>Methods:</b> Hamsters were subcutaneously injected with the pancreatic duct carcinogen <i>N</i>-nitrosobis(2-oxopropyl)amine to induce pancreatic cancer. <i>N</i>-nitrosobis(2-oxopropyl)amine–treated hamsters underwent in vivo SPECT with ¹¹¹In-DOTA-c(RGDfK). After imaging, the tumor-to-normal pancreatic tissue radioactivity ratios in excised pancreatic samples were measured with autoradiography (ARG) and compared with the immunopathologic findings for α_vβ₃-integrin. In a mouse model in which inflammation was induced with turpentine, the uptake of ¹¹¹In-DOTA-c(RGDfK) in inflammatory regions was evaluated with ARG and compared with that of ¹⁸F-FDG. <b>Results:</b>¹¹¹In-DOTA-c(RGDfK) was clearly visualized in pancreatic cancer lesions as small as 3 mm in diameter. ARG analysis revealed high tumor-to-normal pancreatic tissue radioactivity ratios (4.6 ± 1.0 [mean ± SD] in adenocarcinoma and 3.3 ± 1.4 in atypical hyperplasia). The uptake of ¹¹¹In-DOTA-c(RGDfK) strongly correlated with α_vβ₃-integrin expression. In the inflammatory model, inflammation-to-muscle ratios for ¹⁸F-FDG and ¹¹¹In-DOTA-c(RGDfK) were 8.37 ± 4.37 and 1.98 ± 0.60, respectively. These results imply that ¹¹¹In-DOTA-c(RGDfK) has a lower rate of false-positive tumor detection than ¹⁸F-FDG. <b>Conclusion:</b> Our findings suggest that SPECT with ¹¹¹In-DOTA-c(RGDfK) has great potential for the early and accurate detection of pancreatic cancer." @default.
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• W2103670349 date "2012-04-10" @default.
• W2103670349 modified "2023-10-18" @default.
• W2103670349 title "In Vivo SPECT Imaging with 111In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model" @default.
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• W2103670349 doi "https://doi.org/10.2967/jnumed.111.099630" @default.
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