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- W2103670578 abstract "Pharmacogenetic research aims to study how genetic variation may influence drug efficacy and/or toxicity; pharmacogenomics expands this quest to the entire genome. Pharmacogenetic findings may help to uncover new drug targets, illuminate pathophysiology, clarify disease heterogeneity, aid in the fine-mapping of genetic associations, and contribute to personalized treatment. In diabetes, there is precedent for the successful application of pharmacogenetic concepts to monogenic forms of the disease, such as maturity onset diabetes of the young or neonatal diabetes. Whether similar insights will be produced for the common form of type 2 diabetes remains to be seen. With recent advances in genetic approaches, the successive application of candidate gene studies, large-scale genotyping studies and genome-wide association studies has begun to generate suggestive results that may lead to changes in clinical practice. However, many potential barriers to the translation of pharmacogenetic discoveries to the clinical management of diabetes still remain. Here, we offer a contemporary overview of the field in its current state, identify potential obstacles, and highlight future directions." @default.
- W2103670578 created "2016-06-24" @default.
- W2103670578 creator A5046243109 @default.
- W2103670578 creator A5047478353 @default.
- W2103670578 date "2011-01-01" @default.
- W2103670578 modified "2023-09-26" @default.
- W2103670578 title "Pharmacogenetics in type 2 diabetes: potential implications for clinical practice" @default.
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- W2103670578 doi "https://doi.org/10.1186/gm292" @default.
- W2103670578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3308031" @default.
- W2103670578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22126607" @default.
- W2103670578 hasPublicationYear "2011" @default.
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