Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103672914> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2103672914 abstract "For clinical trials where the variable of interest is ordered and categorical (for example, disease severity, symptom scale), and where measurements are taken at intervals, it might be possible to achieve a greater discrimination between the efficacy of treatments by modelling each patient's progress as a stochastic process. The random walk is a simple, easily interpreted model that can be fitted by maximum likelihood using a maximization routine with inference based on standard likelihood theory. In general the model can allow for randomly censored data, incorporates measured prognostic factors, and inference is conditional on the (possibly non-random) allocation of patients. Tests of fit and of model assumptions are proposed, and application to two therapeutic trials of gastroenterological disorders are presented. The model gave measures of the rate of, and variability in, improvement for patients under different treatments. A small simulation study suggested that the model is more powerful than considering the difference between initial and final scores, even when applied to data generated by a mechanism other than the random walk model assumed in the analysis. It thus provides a useful additional statistical method for evaluating clinical trials." @default.
- W2103672914 created "2016-06-24" @default.
- W2103672914 creator A5065734975 @default.
- W2103672914 creator A5068957913 @default.
- W2103672914 date "1988-05-01" @default.
- W2103672914 modified "2023-09-24" @default.
- W2103672914 title "A random walk model for evaluating clinical trials involving serial observations" @default.
- W2103672914 cites W1700100541 @default.
- W2103672914 cites W1917413272 @default.
- W2103672914 cites W1984180883 @default.
- W2103672914 cites W2026896929 @default.
- W2103672914 cites W2035934882 @default.
- W2103672914 cites W2036584065 @default.
- W2103672914 cites W2078157219 @default.
- W2103672914 cites W2085107973 @default.
- W2103672914 cites W2322216784 @default.
- W2103672914 cites W4213248042 @default.
- W2103672914 cites W4248886241 @default.
- W2103672914 doi "https://doi.org/10.1002/sim.4780070505" @default.
- W2103672914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3387717" @default.
- W2103672914 hasPublicationYear "1988" @default.
- W2103672914 type Work @default.
- W2103672914 sameAs 2103672914 @default.
- W2103672914 citedByCount "7" @default.
- W2103672914 countsByYear W21036729142012 @default.
- W2103672914 countsByYear W21036729142013 @default.
- W2103672914 countsByYear W21036729142017 @default.
- W2103672914 crossrefType "journal-article" @default.
- W2103672914 hasAuthorship W2103672914A5065734975 @default.
- W2103672914 hasAuthorship W2103672914A5068957913 @default.
- W2103672914 hasConcept C105795698 @default.
- W2103672914 hasConcept C114289077 @default.
- W2103672914 hasConcept C121194460 @default.
- W2103672914 hasConcept C126255220 @default.
- W2103672914 hasConcept C126322002 @default.
- W2103672914 hasConcept C134261354 @default.
- W2103672914 hasConcept C142724271 @default.
- W2103672914 hasConcept C149782125 @default.
- W2103672914 hasConcept C154945302 @default.
- W2103672914 hasConcept C168743327 @default.
- W2103672914 hasConcept C182081679 @default.
- W2103672914 hasConcept C2776214188 @default.
- W2103672914 hasConcept C2776330181 @default.
- W2103672914 hasConcept C33923547 @default.
- W2103672914 hasConcept C41008148 @default.
- W2103672914 hasConcept C49781872 @default.
- W2103672914 hasConcept C5274069 @default.
- W2103672914 hasConcept C535046627 @default.
- W2103672914 hasConcept C71924100 @default.
- W2103672914 hasConcept C95190672 @default.
- W2103672914 hasConceptScore W2103672914C105795698 @default.
- W2103672914 hasConceptScore W2103672914C114289077 @default.
- W2103672914 hasConceptScore W2103672914C121194460 @default.
- W2103672914 hasConceptScore W2103672914C126255220 @default.
- W2103672914 hasConceptScore W2103672914C126322002 @default.
- W2103672914 hasConceptScore W2103672914C134261354 @default.
- W2103672914 hasConceptScore W2103672914C142724271 @default.
- W2103672914 hasConceptScore W2103672914C149782125 @default.
- W2103672914 hasConceptScore W2103672914C154945302 @default.
- W2103672914 hasConceptScore W2103672914C168743327 @default.
- W2103672914 hasConceptScore W2103672914C182081679 @default.
- W2103672914 hasConceptScore W2103672914C2776214188 @default.
- W2103672914 hasConceptScore W2103672914C2776330181 @default.
- W2103672914 hasConceptScore W2103672914C33923547 @default.
- W2103672914 hasConceptScore W2103672914C41008148 @default.
- W2103672914 hasConceptScore W2103672914C49781872 @default.
- W2103672914 hasConceptScore W2103672914C5274069 @default.
- W2103672914 hasConceptScore W2103672914C535046627 @default.
- W2103672914 hasConceptScore W2103672914C71924100 @default.
- W2103672914 hasConceptScore W2103672914C95190672 @default.
- W2103672914 hasLocation W21036729141 @default.
- W2103672914 hasLocation W21036729142 @default.
- W2103672914 hasOpenAccess W2103672914 @default.
- W2103672914 hasPrimaryLocation W21036729141 @default.
- W2103672914 hasRelatedWork W2021510354 @default.
- W2103672914 hasRelatedWork W2066270048 @default.
- W2103672914 hasRelatedWork W2103672914 @default.
- W2103672914 hasRelatedWork W2171342382 @default.
- W2103672914 hasRelatedWork W2615355269 @default.
- W2103672914 hasRelatedWork W3080881635 @default.
- W2103672914 hasRelatedWork W3148645141 @default.
- W2103672914 hasRelatedWork W3183730129 @default.
- W2103672914 hasRelatedWork W627330005 @default.
- W2103672914 hasRelatedWork W71890765 @default.
- W2103672914 isParatext "false" @default.
- W2103672914 isRetracted "false" @default.
- W2103672914 magId "2103672914" @default.
- W2103672914 workType "article" @default.