Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103705495> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2103705495 endingPage "105" @default.
- W2103705495 startingPage "99" @default.
- W2103705495 abstract "The peptide amylin (previously termed Diabetes Associated Peptide) has recently been isolated and characterised from the amyloid of the pancreatic islets of Langerhans from human type 2 diabetics. Amylin shows about 46% identity in amino acid sequence on comparison with the calcitonin gene-related peptides (CGRPs) and also shows some similarity to insulin. Recent studies have also shown that both amylin and CGRP are potent inhibitors of insulin-stimulated glycogen synthesis in skeletal muscle in vitro. Hormones may be arranged into families, therefore a degree of order exists even though hormone-mediated effects are complex. The polypeptides insulin, insulin-like growth factors (IGFs) and relaxins have been grouped into such a family with similarities both at the protein-structural and genetic levels. We now demonstrate that this insulin-related family, along with amylin and the CGRPs, are members of a peptide superfamily defined by structural similarity in the region corresponding to the A-chain of insulin. In order to distinguish this grouping of small biologically active peptides from the previous one, we have designated it the amylin superfamily. All the members of the previously defined insulin family have a region homologous to the insulin B-chain. Insulin, the IGFs, the relaxins, the CGRPs and amylin are all involved in carbohydrate metabolism and therefore these peptides are functionally as well as structurally related. This grouping of peptides may have important implications for the study of human metabolic disease." @default.
- W2103705495 created "2016-06-24" @default.
- W2103705495 creator A5006588214 @default.
- W2103705495 creator A5008135418 @default.
- W2103705495 creator A5068114848 @default.
- W2103705495 creator A5091261306 @default.
- W2103705495 date "1989-01-01" @default.
- W2103705495 modified "2023-10-15" @default.
- W2103705495 title "The amylin superfamily: A novel grouping of biologically active polypeptides related to the insulin A-chain" @default.
- W2103705495 cites W1488424161 @default.
- W2103705495 cites W1518942907 @default.
- W2103705495 cites W1928593782 @default.
- W2103705495 cites W1972454974 @default.
- W2103705495 cites W1973857041 @default.
- W2103705495 cites W1977949195 @default.
- W2103705495 cites W1996343815 @default.
- W2103705495 cites W2000456774 @default.
- W2103705495 cites W2001337273 @default.
- W2103705495 cites W2004674974 @default.
- W2103705495 cites W2006544477 @default.
- W2103705495 cites W2021315061 @default.
- W2103705495 cites W2023430158 @default.
- W2103705495 cites W2029195137 @default.
- W2103705495 cites W2033066280 @default.
- W2103705495 cites W2034109892 @default.
- W2103705495 cites W2045466835 @default.
- W2103705495 cites W2053277833 @default.
- W2103705495 cites W2056803014 @default.
- W2103705495 cites W2058303999 @default.
- W2103705495 cites W2059592132 @default.
- W2103705495 cites W2060129924 @default.
- W2103705495 cites W2089751119 @default.
- W2103705495 cites W2152848856 @default.
- W2103705495 cites W2224676279 @default.
- W2103705495 cites W307624243 @default.
- W2103705495 cites W4299832793 @default.
- W2103705495 doi "https://doi.org/10.1016/0955-2235(89)90004-5" @default.
- W2103705495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2491258" @default.
- W2103705495 hasPublicationYear "1989" @default.
- W2103705495 type Work @default.
- W2103705495 sameAs 2103705495 @default.
- W2103705495 citedByCount "22" @default.
- W2103705495 countsByYear W21037054952012 @default.
- W2103705495 crossrefType "journal-article" @default.
- W2103705495 hasAuthorship W2103705495A5006588214 @default.
- W2103705495 hasAuthorship W2103705495A5008135418 @default.
- W2103705495 hasAuthorship W2103705495A5068114848 @default.
- W2103705495 hasAuthorship W2103705495A5091261306 @default.
- W2103705495 hasConcept C104317684 @default.
- W2103705495 hasConcept C126322002 @default.
- W2103705495 hasConcept C134018914 @default.
- W2103705495 hasConcept C165220095 @default.
- W2103705495 hasConcept C167625842 @default.
- W2103705495 hasConcept C185592680 @default.
- W2103705495 hasConcept C2777633098 @default.
- W2103705495 hasConcept C2779281246 @default.
- W2103705495 hasConcept C2779306644 @default.
- W2103705495 hasConcept C2780705028 @default.
- W2103705495 hasConcept C55493867 @default.
- W2103705495 hasConcept C59822182 @default.
- W2103705495 hasConcept C71924100 @default.
- W2103705495 hasConcept C86803240 @default.
- W2103705495 hasConceptScore W2103705495C104317684 @default.
- W2103705495 hasConceptScore W2103705495C126322002 @default.
- W2103705495 hasConceptScore W2103705495C134018914 @default.
- W2103705495 hasConceptScore W2103705495C165220095 @default.
- W2103705495 hasConceptScore W2103705495C167625842 @default.
- W2103705495 hasConceptScore W2103705495C185592680 @default.
- W2103705495 hasConceptScore W2103705495C2777633098 @default.
- W2103705495 hasConceptScore W2103705495C2779281246 @default.
- W2103705495 hasConceptScore W2103705495C2779306644 @default.
- W2103705495 hasConceptScore W2103705495C2780705028 @default.
- W2103705495 hasConceptScore W2103705495C55493867 @default.
- W2103705495 hasConceptScore W2103705495C59822182 @default.
- W2103705495 hasConceptScore W2103705495C71924100 @default.
- W2103705495 hasConceptScore W2103705495C86803240 @default.
- W2103705495 hasIssue "2" @default.
- W2103705495 hasLocation W21037054951 @default.
- W2103705495 hasLocation W21037054952 @default.
- W2103705495 hasOpenAccess W2103705495 @default.
- W2103705495 hasPrimaryLocation W21037054951 @default.
- W2103705495 hasRelatedWork W1968759076 @default.
- W2103705495 hasRelatedWork W1978644848 @default.
- W2103705495 hasRelatedWork W1999909300 @default.
- W2103705495 hasRelatedWork W2144574657 @default.
- W2103705495 hasRelatedWork W2783111266 @default.
- W2103705495 hasRelatedWork W2967002357 @default.
- W2103705495 hasRelatedWork W2998585388 @default.
- W2103705495 hasRelatedWork W3028323271 @default.
- W2103705495 hasRelatedWork W4296503608 @default.
- W2103705495 hasRelatedWork W3091532576 @default.
- W2103705495 hasVolume "1" @default.
- W2103705495 isParatext "false" @default.
- W2103705495 isRetracted "false" @default.
- W2103705495 magId "2103705495" @default.
- W2103705495 workType "article" @default.