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- W2103706525 endingPage "E3" @default.
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- W2103706525 abstract "This review considers the 2 sources of neurotrophic factors in the peripheral nervous system (PNS), the neurons and the nonneuronal cells in the denervated distal nerve stumps, and their role in axon regeneration. Morphological assessment of regenerative success in response to administration of exogenous growth factors after nerve injury and repair has indicated a role of the endogenous neurotrophic factors from Schwann cells in the distal nerve stump. However, the increased number of axons may reflect more neurons regenerating their axons and/or increased numbers of axon sprouts from the same number of neurons. Using fluorescent dyes to count neurons that regenerated their axons across a suture site and into distal nerve stumps, brain-derived neurotrophic factor (BDNF) and glial cell–derived neurotrophic factor (GDNF) were found not to increase the number of neurons that regenerated their axons after immediate nerve repair. Nevertheless, the factors did reverse the deleterious effect of delayed nerve repair, indicating that the axons that regenerate into the distal nerve stump normally have access to sufficient levels of endogenous neurotrophic factors to sustain their regeneration, while neurons that do not have access to these factors require exogenous factors to sustain axon regeneration. Neurons upregulate neurotrophic factors after axotomy. The upregulation is normally slow, beginning after 7 days and occurring in association with a protracted period of axonal regeneration in which axons grow out from the proximal nerve stump across a suture site over a period of 1 month in rodents. This staggered axon regeneration across the suture site is accelerated by a 1-hour period of low-frequency electrical stimulation that simultaneously accelerates the expression of BDNF and its trkB receptor in the neurons. Elevation of the level of BDNF after 2 days to > 3 times that found in unstimulated neurons was accompanied by elevation of the level of cAMP and followed by accelerated upregulation of growth-associated genes, tubulin, actin, and GAP-43 and downregulation of neurofilament protein. Elevation of cAMP levels via rolipram inhibition of phosphodiesterase 4 mimicked the effect of the low-frequency electrical stimulation. In conclusion, the enhanced upregulation of neurotrophic factors in the electrically stimulated axotomized neurons accelerates axon outgrowth into the distal nerve stumps where endogenous sources of growth factors in the Schwann cells support the regeneration of the axons toward the denervated targets. The findings provide strong support for endogenous neurotrophic factors of axotomized neurons and of denervated Schwann cells playing a critical role in supporting axon regeneration in the PNS." @default.
- W2103706525 created "2016-06-24" @default.
- W2103706525 creator A5054394317 @default.
- W2103706525 date "2009-02-01" @default.
- W2103706525 modified "2023-10-14" @default.
- W2103706525 title "The role of neurotrophic factors in nerve regeneration" @default.
- W2103706525 cites W129395966 @default.
- W2103706525 cites W136774867 @default.
- W2103706525 cites W1542533968 @default.
- W2103706525 cites W1563372168 @default.
- W2103706525 cites W1763112583 @default.
- W2103706525 cites W1963485034 @default.
- W2103706525 cites W1964837678 @default.
- W2103706525 cites W1970611360 @default.
- W2103706525 cites W1975629533 @default.
- W2103706525 cites W1980010780 @default.
- W2103706525 cites W1983712592 @default.
- W2103706525 cites W1987949333 @default.
- W2103706525 cites W1990590034 @default.
- W2103706525 cites W1991561787 @default.
- W2103706525 cites W1992859263 @default.
- W2103706525 cites W1994452959 @default.
- W2103706525 cites W1996861581 @default.
- W2103706525 cites W1998651522 @default.
- W2103706525 cites W1999972660 @default.
- W2103706525 cites W2000407122 @default.
- W2103706525 cites W2001496659 @default.
- W2103706525 cites W2001952916 @default.
- W2103706525 cites W2002397995 @default.
- W2103706525 cites W2008891455 @default.
- W2103706525 cites W2009678341 @default.
- W2103706525 cites W2010656305 @default.
- W2103706525 cites W2010836166 @default.
- W2103706525 cites W2012423618 @default.
- W2103706525 cites W2014203854 @default.
- W2103706525 cites W2015133844 @default.
- W2103706525 cites W2017713576 @default.
- W2103706525 cites W2018068734 @default.
- W2103706525 cites W2020340848 @default.
- W2103706525 cites W2021224039 @default.
- W2103706525 cites W2023383781 @default.
- W2103706525 cites W2025344934 @default.
- W2103706525 cites W2026847407 @default.
- W2103706525 cites W2030789939 @default.
- W2103706525 cites W2032166890 @default.
- W2103706525 cites W2036476074 @default.
- W2103706525 cites W2036782893 @default.
- W2103706525 cites W2037335353 @default.
- W2103706525 cites W2037572037 @default.
- W2103706525 cites W2038894443 @default.
- W2103706525 cites W2044933487 @default.
- W2103706525 cites W2047371948 @default.
- W2103706525 cites W2047751243 @default.
- W2103706525 cites W2048935170 @default.
- W2103706525 cites W2049734047 @default.
- W2103706525 cites W2051654171 @default.
- W2103706525 cites W2053472287 @default.
- W2103706525 cites W2055149392 @default.
- W2103706525 cites W2058026578 @default.
- W2103706525 cites W2059981328 @default.
- W2103706525 cites W2061572548 @default.
- W2103706525 cites W2064934483 @default.
- W2103706525 cites W2066342229 @default.
- W2103706525 cites W2067435357 @default.
- W2103706525 cites W2074959702 @default.
- W2103706525 cites W2078099913 @default.
- W2103706525 cites W2083419195 @default.
- W2103706525 cites W2086404019 @default.
- W2103706525 cites W2088134619 @default.
- W2103706525 cites W2088406732 @default.
- W2103706525 cites W2089057377 @default.
- W2103706525 cites W2089956752 @default.
- W2103706525 cites W2091062647 @default.
- W2103706525 cites W2092539489 @default.
- W2103706525 cites W2093229003 @default.
- W2103706525 cites W2097678807 @default.
- W2103706525 cites W2098572051 @default.
- W2103706525 cites W2108683751 @default.
- W2103706525 cites W2109789918 @default.
- W2103706525 cites W2110301830 @default.
- W2103706525 cites W2115147679 @default.
- W2103706525 cites W2115656877 @default.
- W2103706525 cites W2126961438 @default.
- W2103706525 cites W2128960139 @default.
- W2103706525 cites W2132964176 @default.
- W2103706525 cites W2136511265 @default.
- W2103706525 cites W2137524928 @default.
- W2103706525 cites W2137979524 @default.
- W2103706525 cites W2137999108 @default.
- W2103706525 cites W2138909102 @default.
- W2103706525 cites W2147813206 @default.
- W2103706525 cites W2157281893 @default.
- W2103706525 cites W2160460092 @default.
- W2103706525 cites W2165959611 @default.
- W2103706525 cites W2262061447 @default.
- W2103706525 cites W2323283291 @default.
- W2103706525 cites W2395426394 @default.
- W2103706525 cites W4213263913 @default.