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- W2103706985 abstract "Common variable immunodeficiency (CVID) is a heterogeneous entity characterized by an impaired ability to produce antibodies. The failure is localized in partially mature B lymphocytes, though T lymphocyte abnormalities are occasionally present. This deficiency affects antibody synthesis and class switch from IgD and IgM, to IgG and IgA. CVID is related to selective IgA deficiency, and both abnormalities may coincide in one same family, and evolve from one to another in the same patient. The symptoms generally manifest in adults, but can occur at any age, even in infancy. Recurrent bacterial infections or pneumonias are frequent, and may be complicated by gastrointestinal problems, granulomas, autoimmune disorders or malignancies. A defect in memory B cells seems to condition the clinical severity. Recently, several mutations in genes encoding for molecules (CD19, TACI, ICOS) involved in B cell survival and isotype switch have been identified in patients with CVID. Nevertheless, genetic abnormalities have been found in less than 25 % of cases with CVID; the underlying mechanism thus remains unknown in the majority of CVID patients, and research in this field must continue." @default.
- W2103706985 created "2016-06-24" @default.
- W2103706985 creator A5015455451 @default.
- W2103706985 creator A5031899943 @default.
- W2103706985 creator A5059655739 @default.
- W2103706985 creator A5069234859 @default.
- W2103706985 date "2006-11-01" @default.
- W2103706985 modified "2023-09-27" @default.
- W2103706985 title "Common variable immunodeficiency. Old questions are getting clearer" @default.
- W2103706985 cites W1492447786 @default.
- W2103706985 cites W1504970236 @default.
- W2103706985 cites W1573128760 @default.
- W2103706985 cites W1908619457 @default.
- W2103706985 cites W1965846074 @default.
- W2103706985 cites W1975045757 @default.
- W2103706985 cites W1977467447 @default.
- W2103706985 cites W1983410474 @default.
- W2103706985 cites W1984605559 @default.
- W2103706985 cites W1985192581 @default.
- W2103706985 cites W1985610677 @default.
- W2103706985 cites W1985968037 @default.
- W2103706985 cites W1987422538 @default.
- W2103706985 cites W1991130982 @default.
- W2103706985 cites W1991250422 @default.
- W2103706985 cites W1991499651 @default.
- W2103706985 cites W1992993906 @default.
- W2103706985 cites W1995637189 @default.
- W2103706985 cites W1995924318 @default.
- W2103706985 cites W1997263056 @default.
- W2103706985 cites W1998400254 @default.
- W2103706985 cites W2002056653 @default.
- W2103706985 cites W2002300618 @default.
- W2103706985 cites W2004685689 @default.
- W2103706985 cites W2006034600 @default.
- W2103706985 cites W2012671707 @default.
- W2103706985 cites W2012751406 @default.
- W2103706985 cites W2014173345 @default.
- W2103706985 cites W2014956545 @default.
- W2103706985 cites W2016304443 @default.
- W2103706985 cites W2018915861 @default.
- W2103706985 cites W2019712023 @default.
- W2103706985 cites W2022769546 @default.
- W2103706985 cites W2023439261 @default.
- W2103706985 cites W2025141018 @default.
- W2103706985 cites W2025357775 @default.
- W2103706985 cites W2025462060 @default.
- W2103706985 cites W2026906323 @default.
- W2103706985 cites W2027708376 @default.
- W2103706985 cites W2030627521 @default.
- W2103706985 cites W2032192796 @default.
- W2103706985 cites W2036117506 @default.
- W2103706985 cites W2042928243 @default.
- W2103706985 cites W2044983161 @default.
- W2103706985 cites W2045518177 @default.
- W2103706985 cites W2046752196 @default.
- W2103706985 cites W2047662292 @default.
- W2103706985 cites W2055338105 @default.
- W2103706985 cites W2055903080 @default.
- W2103706985 cites W2061728533 @default.
- W2103706985 cites W2066100434 @default.
- W2103706985 cites W2068715499 @default.
- W2103706985 cites W2072238743 @default.
- W2103706985 cites W2075824433 @default.
- W2103706985 cites W2078752798 @default.
- W2103706985 cites W2085869929 @default.
- W2103706985 cites W2087936274 @default.
- W2103706985 cites W2089996985 @default.
- W2103706985 cites W2090102698 @default.
- W2103706985 cites W2094953514 @default.
- W2103706985 cites W2104988432 @default.
- W2103706985 cites W2106134589 @default.
- W2103706985 cites W2106191188 @default.
- W2103706985 cites W2108793518 @default.
- W2103706985 cites W2115016218 @default.
- W2103706985 cites W2122763303 @default.
- W2103706985 cites W2125423714 @default.
- W2103706985 cites W2126359181 @default.
- W2103706985 cites W2128875218 @default.
- W2103706985 cites W2130651020 @default.
- W2103706985 cites W2136590857 @default.
- W2103706985 cites W2136920402 @default.
- W2103706985 cites W2137133725 @default.
- W2103706985 cites W2137688821 @default.
- W2103706985 cites W2144373122 @default.
- W2103706985 cites W2149175094 @default.
- W2103706985 cites W2150721047 @default.
- W2103706985 cites W2152733931 @default.
- W2103706985 cites W2154696313 @default.
- W2103706985 cites W2162452586 @default.
- W2103706985 cites W2165454502 @default.
- W2103706985 cites W2166022914 @default.
- W2103706985 cites W2169835912 @default.
- W2103706985 cites W2169884632 @default.
- W2103706985 cites W2331462628 @default.
- W2103706985 cites W2336592371 @default.
- W2103706985 cites W2337413481 @default.
- W2103706985 cites W265320334 @default.
- W2103706985 cites W4238558113 @default.
- W2103706985 cites W4301502254 @default.
- W2103706985 doi "https://doi.org/10.1157/13095875" @default.