FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103707468> ?p ?o ?g. }

• W2103707468 endingPage "924" @default.
• W2103707468 startingPage "919" @default.
• W2103707468 abstract "To study the association between trough ribavirin concentration (Ctrough) with sustained virological response (SVR) and haemoglobin (Hb) decrease in HIV/hepatitis C virus (HCV)-co-infected (HIV+/HCV+) patients treated with anti-HCV therapy. HIV+/HCV+ patients treated with ribavirin and pegylated interferon were prospectively evaluated. Qualitative and quantitative HCV-RNA, Hb levels and ribavirin Ctrough were measured at baseline and weeks 2, 4, 12, 24, 36 and 48 during therapy. HCV-RNA was also measured at 24 weeks after the end of therapy. Efficacy analysis was performed on patients with a definitive virological outcome (SVR, relapser and non-responder), whereas for toxicity analysis, dropouts were considered until the last available observation. Fifty-two patients (54.7% with genotype 1 or 4) were included. Overall, no correlation between ribavirin Ctrough and early virological response (EVR) nor SVR was found. However, in patients with genotype 1 or 4, ribavirin Ctrough was independently associated with EVR (P = 0.036) and SVR (P = 0.046). A ribavirin Ctrough cut-off of 1600 ng/mL was found to be associated with both EVR (χ2 = 5.69, P = 0.028) and SVR (χ2=4.2, P = 0.04). Higher ribavirin Ctrough correlated with Hb decrease (R = −0.361, P = 0.009) and was independently associated with an Hb decrease of >4 g/dL (P = 0.009). Receiver operating characteristic (ROC) analysis indicated that a ribavirin Ctrough of >2300 ng/mL was associated with an Hb decrease of >4 g/dL (χ2 = 8.08, P = 0.01). Our study confirmed a relationship between ribavirin exposure and both efficacy and toxicity. Moreover, we found ribavirin Ctrough cut-offs for both SVR in genotypes 1 and 4 and overall haematological toxicity. These findings deserve further clinical evaluation." @default.
• W2103707468 created "2016-06-24" @default.
• W2103707468 creator A5018601414 @default.
• W2103707468 creator A5021206943 @default.
• W2103707468 creator A5030234607 @default.
• W2103707468 creator A5033236355 @default.
• W2103707468 creator A5038706116 @default.
• W2103707468 creator A5046489228 @default.
• W2103707468 creator A5050025219 @default.
• W2103707468 creator A5050643464 @default.
• W2103707468 creator A5052366087 @default.
• W2103707468 creator A5058603188 @default.
• W2103707468 creator A5066075665 @default.
• W2103707468 creator A5070034219 @default.
• W2103707468 creator A5076836884 @default.
• W2103707468 creator A5087095797 @default.
• W2103707468 date "2008-02-04" @default.
• W2103707468 modified "2023-10-18" @default.
• W2103707468 title "The use of trough ribavirin concentration to predict sustained virological response and haematological toxicity in HIV/HCV-co-infected patients treated with ribavirin and pegylated interferon" @default.
• W2103707468 cites W1550111394 @default.
• W2103707468 cites W1964264521 @default.
• W2103707468 cites W1974441545 @default.
• W2103707468 cites W1993484328 @default.
• W2103707468 cites W1996434966 @default.
• W2103707468 cites W1997755547 @default.
• W2103707468 cites W2007062588 @default.
• W2103707468 cites W2007122128 @default.
• W2103707468 cites W2007209701 @default.
• W2103707468 cites W2027545702 @default.
• W2103707468 cites W2027992424 @default.
• W2103707468 cites W2050660031 @default.
• W2103707468 cites W2087073512 @default.
• W2103707468 cites W2090370866 @default.
• W2103707468 cites W2112876622 @default.
• W2103707468 cites W2119924468 @default.
• W2103707468 cites W2121595515 @default.
• W2103707468 cites W2122764811 @default.
• W2103707468 cites W2127685726 @default.
• W2103707468 cites W2143519512 @default.
• W2103707468 cites W2155600971 @default.
• W2103707468 doi "https://doi.org/10.1093/jac/dkn013" @default.
• W2103707468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18238889" @default.
• W2103707468 hasPublicationYear "2008" @default.
• W2103707468 type Work @default.
• W2103707468 sameAs 2103707468 @default.
• W2103707468 citedByCount "39" @default.
• W2103707468 countsByYear W21037074682012 @default.
• W2103707468 countsByYear W21037074682013 @default.
• W2103707468 countsByYear W21037074682014 @default.
• W2103707468 countsByYear W21037074682015 @default.
• W2103707468 countsByYear W21037074682016 @default.
• W2103707468 countsByYear W21037074682017 @default.
• W2103707468 countsByYear W21037074682019 @default.
• W2103707468 countsByYear W21037074682020 @default.
• W2103707468 countsByYear W21037074682022 @default.
• W2103707468 crossrefType "journal-article" @default.
• W2103707468 hasAuthorship W2103707468A5018601414 @default.
• W2103707468 hasAuthorship W2103707468A5021206943 @default.
• W2103707468 hasAuthorship W2103707468A5030234607 @default.
• W2103707468 hasAuthorship W2103707468A5033236355 @default.
• W2103707468 hasAuthorship W2103707468A5038706116 @default.
• W2103707468 hasAuthorship W2103707468A5046489228 @default.
• W2103707468 hasAuthorship W2103707468A5050025219 @default.
• W2103707468 hasAuthorship W2103707468A5050643464 @default.
• W2103707468 hasAuthorship W2103707468A5052366087 @default.
• W2103707468 hasAuthorship W2103707468A5058603188 @default.
• W2103707468 hasAuthorship W2103707468A5066075665 @default.
• W2103707468 hasAuthorship W2103707468A5070034219 @default.
• W2103707468 hasAuthorship W2103707468A5076836884 @default.
• W2103707468 hasAuthorship W2103707468A5087095797 @default.
• W2103707468 hasConcept C126322002 @default.
• W2103707468 hasConcept C142462285 @default.
• W2103707468 hasConcept C203014093 @default.
• W2103707468 hasConcept C2522874641 @default.
• W2103707468 hasConcept C2776408679 @default.
• W2103707468 hasConcept C2776455275 @default.
• W2103707468 hasConcept C2776461080 @default.
• W2103707468 hasConcept C2780040827 @default.
• W2103707468 hasConcept C3013748606 @default.
• W2103707468 hasConcept C71924100 @default.
• W2103707468 hasConcept C90924648 @default.
• W2103707468 hasConceptScore W2103707468C126322002 @default.
• W2103707468 hasConceptScore W2103707468C142462285 @default.
• W2103707468 hasConceptScore W2103707468C203014093 @default.
• W2103707468 hasConceptScore W2103707468C2522874641 @default.
• W2103707468 hasConceptScore W2103707468C2776408679 @default.
• W2103707468 hasConceptScore W2103707468C2776455275 @default.
• W2103707468 hasConceptScore W2103707468C2776461080 @default.
• W2103707468 hasConceptScore W2103707468C2780040827 @default.
• W2103707468 hasConceptScore W2103707468C3013748606 @default.
• W2103707468 hasConceptScore W2103707468C71924100 @default.
• W2103707468 hasConceptScore W2103707468C90924648 @default.
• W2103707468 hasIssue "4" @default.
• W2103707468 hasLocation W21037074681 @default.
• W2103707468 hasLocation W21037074682 @default.
• W2103707468 hasOpenAccess W2103707468 @default.
• W2103707468 hasPrimaryLocation W21037074681 @default.
• W2103707468 hasRelatedWork W1586448152 @default.

• next