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- W2103707955 abstract ". We thank Willem van Eden and colleagues for critically discussing their opinion about the role of heat shock pro‑ teins (HSPs) as damage‑associated molecular patterns (DAMPs). As we discussed in our Review article 1 , the evidence that HSPs act as DAMPs to stimulate immune responses during sterile injury is controversial largely owing to the fact that most purified DAMP preparations, including those of HSPs, con‑ tain varying amounts of contaminating microbial products. Furthermore, HSPs can bind to several pathogen‑associated molecu‑ lar patterns (PAMPs) and enhance Toll‑like receptor (TLR) ligand‑induced stimulation 3–5 , making the interpretation of published results difficult. Because depletion of microbial prod‑ ucts from HSP preparations has been shown to reduce or abolish HSP‑induced inflamma‑ tory responses 6,7" @default.
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- W2103707955 date "2011-07-25" @default.
- W2103707955 modified "2023-10-17" @default.
- W2103707955 title "Are heat shock proteins DAMPs?" @default.
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- W2103707955 doi "https://doi.org/10.1038/nri2873-c2" @default.
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