FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103709809> ?p ?o ?g. }

• W2103709809 endingPage "2779" @default.
• W2103709809 startingPage "2768" @default.
• W2103709809 abstract "Cancer stem cells (CSC) play critical roles in cancer initiation, progression, and therapeutic refractoriness. Although many studies have focused on the genes and pathways involved in stemness, characterization of the factors in the tumor microenvironment that regulate CSCs is lacking. In this study, we investigated the effects of stromal fibroblasts on breast cancer stem cells. We found that compared with normal fibroblasts, primary cancer-associated fibroblasts (CAF) and fibroblasts activated by cocultured breast cancer cells produce higher levels of chemokine (C-C motif) ligand 2 (CCL2), which stimulates the stem cell-specific, sphere-forming phenotype in breast cancer cells and CSC self-renewal. Increased CCL2 expression in activated fibroblasts required STAT3 activation by diverse breast cancer-secreted cytokines, and in turn, induced NOTCH1 expression and the CSC features in breast cancer cells, constituting a cancer-stroma-cancer signaling circuit. In a xenograft model of paired fibroblasts and breast cancer tumor cells, loss of CCL2 significantly inhibited tumorigenesis and NOTCH1 expression. In addition, upregulation of both NOTCH1 and CCL2 was associated with poor differentiation in primary breast cancers, further supporting the observation that NOTCH1 is regulated by CCL2. Our findings therefore suggest that CCL2 represents a potential therapeutic target that can block the cancer-host communication that prompts CSC-mediated disease progression." @default.
• W2103709809 created "2016-06-24" @default.
• W2103709809 creator A5000676360 @default.
• W2103709809 creator A5005985656 @default.
• W2103709809 creator A5006711911 @default.
• W2103709809 creator A5016438289 @default.
• W2103709809 creator A5018193992 @default.
• W2103709809 creator A5021830408 @default.
• W2103709809 creator A5023241639 @default.
• W2103709809 creator A5023917993 @default.
• W2103709809 creator A5027521220 @default.
• W2103709809 creator A5032873521 @default.
• W2103709809 creator A5048790224 @default.
• W2103709809 creator A5054078700 @default.
• W2103709809 creator A5056569468 @default.
• W2103709809 creator A5064649529 @default.
• W2103709809 creator A5066553986 @default.
• W2103709809 creator A5068745963 @default.
• W2103709809 creator A5074216961 @default.
• W2103709809 creator A5081676218 @default.
• W2103709809 creator A5084717592 @default.
• W2103709809 date "2012-05-31" @default.
• W2103709809 modified "2023-10-14" @default.
• W2103709809 title "CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells" @default.
• W2103709809 cites W1963904011 @default.
• W2103709809 cites W1970595107 @default.
• W2103709809 cites W1973220859 @default.
• W2103709809 cites W1973569665 @default.
• W2103709809 cites W1974600364 @default.
• W2103709809 cites W1975907310 @default.
• W2103709809 cites W1979935206 @default.
• W2103709809 cites W1983575915 @default.
• W2103709809 cites W1995725520 @default.
• W2103709809 cites W1996376317 @default.
• W2103709809 cites W1997379399 @default.
• W2103709809 cites W1999356404 @default.
• W2103709809 cites W2003409252 @default.
• W2103709809 cites W2004419844 @default.
• W2103709809 cites W2004578380 @default.
• W2103709809 cites W2004838336 @default.
• W2103709809 cites W2050999762 @default.
• W2103709809 cites W2062809449 @default.
• W2103709809 cites W2077380927 @default.
• W2103709809 cites W2079083095 @default.
• W2103709809 cites W2086159554 @default.
• W2103709809 cites W2096090498 @default.
• W2103709809 cites W2096728388 @default.
• W2103709809 cites W2101974243 @default.
• W2103709809 cites W2112197935 @default.
• W2103709809 cites W2115147216 @default.
• W2103709809 cites W2127107445 @default.
• W2103709809 cites W2127483626 @default.
• W2103709809 cites W2127617517 @default.
• W2103709809 cites W2131795672 @default.
• W2103709809 cites W2133300954 @default.
• W2103709809 cites W2146074268 @default.
• W2103709809 cites W2153051750 @default.
• W2103709809 cites W2156711378 @default.
• W2103709809 cites W2160450758 @default.
• W2103709809 cites W2162647235 @default.
• W2103709809 cites W2164618834 @default.
• W2103709809 cites W2783142245 @default.
• W2103709809 doi "https://doi.org/10.1158/0008-5472.can-11-3567" @default.
• W2103709809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3367125" @default.
• W2103709809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22472119" @default.
• W2103709809 hasPublicationYear "2012" @default.
• W2103709809 type Work @default.
• W2103709809 sameAs 2103709809 @default.
• W2103709809 citedByCount "327" @default.
• W2103709809 countsByYear W21037098092012 @default.
• W2103709809 countsByYear W21037098092013 @default.
• W2103709809 countsByYear W21037098092014 @default.
• W2103709809 countsByYear W21037098092015 @default.
• W2103709809 countsByYear W21037098092016 @default.
• W2103709809 countsByYear W21037098092017 @default.
• W2103709809 countsByYear W21037098092018 @default.
• W2103709809 countsByYear W21037098092019 @default.
• W2103709809 countsByYear W21037098092020 @default.
• W2103709809 countsByYear W21037098092021 @default.
• W2103709809 countsByYear W21037098092022 @default.
• W2103709809 countsByYear W21037098092023 @default.
• W2103709809 crossrefType "journal-article" @default.
• W2103709809 hasAuthorship W2103709809A5000676360 @default.
• W2103709809 hasAuthorship W2103709809A5005985656 @default.
• W2103709809 hasAuthorship W2103709809A5006711911 @default.
• W2103709809 hasAuthorship W2103709809A5016438289 @default.
• W2103709809 hasAuthorship W2103709809A5018193992 @default.
• W2103709809 hasAuthorship W2103709809A5021830408 @default.
• W2103709809 hasAuthorship W2103709809A5023241639 @default.
• W2103709809 hasAuthorship W2103709809A5023917993 @default.
• W2103709809 hasAuthorship W2103709809A5027521220 @default.
• W2103709809 hasAuthorship W2103709809A5032873521 @default.
• W2103709809 hasAuthorship W2103709809A5048790224 @default.
• W2103709809 hasAuthorship W2103709809A5054078700 @default.
• W2103709809 hasAuthorship W2103709809A5056569468 @default.
• W2103709809 hasAuthorship W2103709809A5064649529 @default.
• W2103709809 hasAuthorship W2103709809A5066553986 @default.
• W2103709809 hasAuthorship W2103709809A5068745963 @default.

• next