Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103710818> ?p ?o ?g. }
- W2103710818 endingPage "1572" @default.
- W2103710818 startingPage "1562" @default.
- W2103710818 abstract "ABSTRACT Acute rheumatic fever (ARF) is a postsuppurative sequela caused by Streptococcus pyogenes infections affecting school-age children. We describe here the occurrence of an ARF outbreak that occurred in Bologna province, northeastern Italy, between November 2012 and May 2013. Molecular analysis revealed that ARF-related group A Streptococcus (GAS) strains belonged to the M-18 serotype, including subtypes emm18.29 and emm18.32 . All M-18 GAS strains shared the same antigenic profile, including SpeA, SpeB, SpeC, SpeL, SpeM, and SmeZ. Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) analysis revealed that M-18 GAS strains grouped separately from other serotypes, suggesting a different S. pyogenes lineage. Single nucleotide polymorphisms and phylogenetic analysis based on whole-genome sequencing showed that emm18.29 and emm18.32 GAS strains clustered in two distinct groups, highlighting genetic variations between these subtypes. Comparative analysis revealed a similar genome architecture between emm18.29 and emm18.32 strains that differed from noninvasive emm18.0 strains. The major sources of differences between M-18 genomes were attributable to the prophage elements. Prophage regions contained several virulence factors that could have contributed to the pathogenic potential of emm18.29 and emm18.32 strains. Notably, phage ΦSPBO.1 carried erythrogenic toxin A gene ( speA1 ) in six ARF-related M-18 GAS strains but not in emm18.0 strains. In addition, a phage-encoded hyaluronidase gene ( hylP.2 ) presented different variants among M-18 GAS strains by showing internal deletions located in the α-helical and TSβH regions. In conclusion, our study yielded insights into the genome structure of M-18 GAS strains responsible for the ARF outbreak in Italy, thus expanding our knowledge of this serotype." @default.
- W2103710818 created "2016-06-24" @default.
- W2103710818 creator A5004764897 @default.
- W2103710818 creator A5014214631 @default.
- W2103710818 creator A5033447539 @default.
- W2103710818 creator A5035723838 @default.
- W2103710818 creator A5036277972 @default.
- W2103710818 creator A5040482813 @default.
- W2103710818 creator A5053502988 @default.
- W2103710818 creator A5065283278 @default.
- W2103710818 creator A5070992923 @default.
- W2103710818 creator A5073085116 @default.
- W2103710818 creator A5080583446 @default.
- W2103710818 creator A5001474288 @default.
- W2103710818 date "2015-05-01" @default.
- W2103710818 modified "2023-10-14" @default.
- W2103710818 title "Matrix-Assisted Laser Desorption Ionization–Time of Flight and Comparative Genomic Analysis of M-18 Group A Streptococcus Strains Associated with an Acute Rheumatic Fever Outbreak in Northeast Italy in 2012 and 2013" @default.
- W2103710818 cites W1846221202 @default.
- W2103710818 cites W1979500381 @default.
- W2103710818 cites W1985400292 @default.
- W2103710818 cites W2009588638 @default.
- W2103710818 cites W2015301748 @default.
- W2103710818 cites W2027275977 @default.
- W2103710818 cites W2039360787 @default.
- W2103710818 cites W2041257508 @default.
- W2103710818 cites W2058436455 @default.
- W2103710818 cites W2071103570 @default.
- W2103710818 cites W2072967720 @default.
- W2103710818 cites W2076608234 @default.
- W2103710818 cites W2091030812 @default.
- W2103710818 cites W2093467303 @default.
- W2103710818 cites W2100250586 @default.
- W2103710818 cites W2100363512 @default.
- W2103710818 cites W2100542521 @default.
- W2103710818 cites W2105539777 @default.
- W2103710818 cites W2108383175 @default.
- W2103710818 cites W2110554376 @default.
- W2103710818 cites W2118380724 @default.
- W2103710818 cites W2125245605 @default.
- W2103710818 cites W2127515467 @default.
- W2103710818 cites W2127931698 @default.
- W2103710818 cites W2140288403 @default.
- W2103710818 cites W2144123881 @default.
- W2103710818 cites W2145736155 @default.
- W2103710818 cites W2147805408 @default.
- W2103710818 cites W2161444534 @default.
- W2103710818 cites W2169958686 @default.
- W2103710818 cites W4211043921 @default.
- W2103710818 cites W4237072526 @default.
- W2103710818 cites W4248195861 @default.
- W2103710818 doi "https://doi.org/10.1128/jcm.03465-14" @default.
- W2103710818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4400794" @default.
- W2103710818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25740772" @default.
- W2103710818 hasPublicationYear "2015" @default.
- W2103710818 type Work @default.
- W2103710818 sameAs 2103710818 @default.
- W2103710818 citedByCount "6" @default.
- W2103710818 countsByYear W21037108182016 @default.
- W2103710818 countsByYear W21037108182017 @default.
- W2103710818 countsByYear W21037108182020 @default.
- W2103710818 countsByYear W21037108182021 @default.
- W2103710818 countsByYear W21037108182022 @default.
- W2103710818 countsByYear W21037108182023 @default.
- W2103710818 crossrefType "journal-article" @default.
- W2103710818 hasAuthorship W2103710818A5001474288 @default.
- W2103710818 hasAuthorship W2103710818A5004764897 @default.
- W2103710818 hasAuthorship W2103710818A5014214631 @default.
- W2103710818 hasAuthorship W2103710818A5033447539 @default.
- W2103710818 hasAuthorship W2103710818A5035723838 @default.
- W2103710818 hasAuthorship W2103710818A5036277972 @default.
- W2103710818 hasAuthorship W2103710818A5040482813 @default.
- W2103710818 hasAuthorship W2103710818A5053502988 @default.
- W2103710818 hasAuthorship W2103710818A5065283278 @default.
- W2103710818 hasAuthorship W2103710818A5070992923 @default.
- W2103710818 hasAuthorship W2103710818A5073085116 @default.
- W2103710818 hasAuthorship W2103710818A5080583446 @default.
- W2103710818 hasBestOaLocation W21037108181 @default.
- W2103710818 hasConcept C10389963 @default.
- W2103710818 hasConcept C104317684 @default.
- W2103710818 hasConcept C116675565 @default.
- W2103710818 hasConcept C126322002 @default.
- W2103710818 hasConcept C141231307 @default.
- W2103710818 hasConcept C159047783 @default.
- W2103710818 hasConcept C193252679 @default.
- W2103710818 hasConcept C2776441376 @default.
- W2103710818 hasConcept C2778276568 @default.
- W2103710818 hasConcept C2779306812 @default.
- W2103710818 hasConcept C2779489039 @default.
- W2103710818 hasConcept C2780678043 @default.
- W2103710818 hasConcept C523546767 @default.
- W2103710818 hasConcept C54355233 @default.
- W2103710818 hasConcept C547475151 @default.
- W2103710818 hasConcept C60987743 @default.
- W2103710818 hasConcept C71924100 @default.
- W2103710818 hasConcept C73445445 @default.
- W2103710818 hasConcept C86803240 @default.
- W2103710818 hasConcept C89423630 @default.
- W2103710818 hasConceptScore W2103710818C10389963 @default.