FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103711229> ?p ?o ?g. }

• W2103711229 endingPage "2030" @default.
• W2103711229 startingPage "2023" @default.
• W2103711229 abstract "Death-associated protein kinase (DAPK), a mediator of apoptotic systems, is silenced by promoter hypermethylation in lung and breast tumors. This gene has a CpG island extending 2500 bp from the translational start site; however, studies characterizing its transcriptional regulation have not been conducted. Two transcripts for DAPK were identified that code for a single protein, while being regulated by two promoters. The previously identified DAPK transcript designated as exon 1 transcript was expressed at levels 3-fold greater than the alternate exon 1b transcript. Deletion constructs of promoter 1 identified a 332 bp region containing a functional CP2-binding site important for expression of the exon 1 transcript. While moderate reporter activity was seen in promoter 2, the region comprising intron 1 and containing a HNF3B-binding site sustained expression of the alternate transcript. Sequencing the DAPK CpG island in tumor cell lines revealed dense, but heterogenous methylation of CpGs that blocked access of the CP2 and HNF3B proteins that in turn, was associated with loss of transcription that was restored by treatment with 5-aza-2'-deoxycytidine. Prevalences were similar for methylation of promoter 1 and 2 and intron 1 in lung tumors, but significantly greater in promoter 2 and intron 1 in breast tumors, indicative of tissue-specific differences in silencing these two transcripts. These studies show for the first time dual promoter regulation of DAPK, a tumor suppressor gene silenced in many cancers, and substantiate the importance of screening for silencing of both transcripts in tumors." @default.
• W2103711229 created "2016-06-24" @default.
• W2103711229 creator A5010683495 @default.
• W2103711229 creator A5037186959 @default.
• W2103711229 creator A5039066350 @default.
• W2103711229 creator A5076766244 @default.
• W2103711229 creator A5080346583 @default.
• W2103711229 creator A5083457517 @default.
• W2103711229 creator A5090214263 @default.
• W2103711229 date "2009-11-16" @default.
• W2103711229 modified "2023-10-14" @default.
• W2103711229 title "Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer" @default.
• W2103711229 cites W1493931678 @default.
• W2103711229 cites W1563458559 @default.
• W2103711229 cites W1972562562 @default.
• W2103711229 cites W1977860512 @default.
• W2103711229 cites W1978664503 @default.
• W2103711229 cites W2005397075 @default.
• W2103711229 cites W2025594599 @default.
• W2103711229 cites W2031308320 @default.
• W2103711229 cites W2032908247 @default.
• W2103711229 cites W2035746042 @default.
• W2103711229 cites W2040149948 @default.
• W2103711229 cites W2047509412 @default.
• W2103711229 cites W2049413309 @default.
• W2103711229 cites W2052543236 @default.
• W2103711229 cites W2056786421 @default.
• W2103711229 cites W2064879068 @default.
• W2103711229 cites W2074300163 @default.
• W2103711229 cites W2081935339 @default.
• W2103711229 cites W2088230474 @default.
• W2103711229 cites W2093587470 @default.
• W2103711229 cites W2095515726 @default.
• W2103711229 cites W2102368084 @default.
• W2103711229 cites W2111233859 @default.
• W2103711229 cites W2111599440 @default.
• W2103711229 cites W2117819670 @default.
• W2103711229 cites W2125898440 @default.
• W2103711229 cites W2161005330 @default.
• W2103711229 cites W2318855924 @default.
• W2103711229 cites W4229952372 @default.
• W2103711229 doi "https://doi.org/10.1093/carcin/bgp276" @default.
• W2103711229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2792322" @default.
• W2103711229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19917631" @default.
• W2103711229 hasPublicationYear "2009" @default.
• W2103711229 type Work @default.
• W2103711229 sameAs 2103711229 @default.
• W2103711229 citedByCount "17" @default.
• W2103711229 countsByYear W21037112292013 @default.
• W2103711229 countsByYear W21037112292014 @default.
• W2103711229 countsByYear W21037112292015 @default.
• W2103711229 countsByYear W21037112292016 @default.
• W2103711229 countsByYear W21037112292017 @default.
• W2103711229 countsByYear W21037112292018 @default.
• W2103711229 countsByYear W21037112292019 @default.
• W2103711229 countsByYear W21037112292020 @default.
• W2103711229 countsByYear W21037112292023 @default.
• W2103711229 crossrefType "journal-article" @default.
• W2103711229 hasAuthorship W2103711229A5010683495 @default.
• W2103711229 hasAuthorship W2103711229A5037186959 @default.
• W2103711229 hasAuthorship W2103711229A5039066350 @default.
• W2103711229 hasAuthorship W2103711229A5076766244 @default.
• W2103711229 hasAuthorship W2103711229A5080346583 @default.
• W2103711229 hasAuthorship W2103711229A5083457517 @default.
• W2103711229 hasAuthorship W2103711229A5090214263 @default.
• W2103711229 hasBestOaLocation W21037112291 @default.
• W2103711229 hasConcept C101762097 @default.
• W2103711229 hasConcept C104317684 @default.
• W2103711229 hasConcept C119056186 @default.
• W2103711229 hasConcept C138885662 @default.
• W2103711229 hasConcept C140173407 @default.
• W2103711229 hasConcept C150194340 @default.
• W2103711229 hasConcept C153911025 @default.
• W2103711229 hasConcept C165864922 @default.
• W2103711229 hasConcept C179926584 @default.
• W2103711229 hasConcept C190727270 @default.
• W2103711229 hasConcept C2778264664 @default.
• W2103711229 hasConcept C33288867 @default.
• W2103711229 hasConcept C36823959 @default.
• W2103711229 hasConcept C37080517 @default.
• W2103711229 hasConcept C41895202 @default.
• W2103711229 hasConcept C502942594 @default.
• W2103711229 hasConcept C54355233 @default.
• W2103711229 hasConcept C555283112 @default.
• W2103711229 hasConcept C86803240 @default.
• W2103711229 hasConcept C94671646 @default.
• W2103711229 hasConceptScore W2103711229C101762097 @default.
• W2103711229 hasConceptScore W2103711229C104317684 @default.
• W2103711229 hasConceptScore W2103711229C119056186 @default.
• W2103711229 hasConceptScore W2103711229C138885662 @default.
• W2103711229 hasConceptScore W2103711229C140173407 @default.
• W2103711229 hasConceptScore W2103711229C150194340 @default.
• W2103711229 hasConceptScore W2103711229C153911025 @default.
• W2103711229 hasConceptScore W2103711229C165864922 @default.
• W2103711229 hasConceptScore W2103711229C179926584 @default.
• W2103711229 hasConceptScore W2103711229C190727270 @default.
• W2103711229 hasConceptScore W2103711229C2778264664 @default.
• W2103711229 hasConceptScore W2103711229C33288867 @default.

• next