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- W2103711259 abstract "The loss of neuronal cells, a prominent event in the development of the nervous system, involves regulated triggering of programmed cell death, followed by efficient removal of cell corpses. Professional phagocytes, such as microglia, contribute to the elimination of dead cells. Here we provide evidence that, in addition to their phagocytic activity, microglia promote the death of developing neurons engaged in synaptogenesis. In the developing mouse cerebellum, Purkinje cells die, and 60% of these neurons that already expressed activated caspase-3 were engulfed or contacted by spreading processes emitted by microglial cells. Apoptosis of Purkinje cells in cerebellar slices was strongly reduced by selective elimination of microglia. Superoxide ions produced by microglial respiratory bursts played a major role in this Purkinje cell death. Our study illustrates a mammalian form of engulfment-promoted cell death that links the execution of neuron death to the scavenging of dead cells." @default.
- W2103711259 created "2016-06-24" @default.
- W2103711259 creator A5014311188 @default.
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- W2103711259 creator A5064759494 @default.
- W2103711259 creator A5079003683 @default.
- W2103711259 creator A5081037763 @default.
- W2103711259 date "2004-02-01" @default.
- W2103711259 modified "2023-10-17" @default.
- W2103711259 title "Microglia Promote the Death of Developing Purkinje Cells" @default.
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- W2103711259 doi "https://doi.org/10.1016/s0896-6273(04)00069-8" @default.
- W2103711259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14980203" @default.
- W2103711259 hasPublicationYear "2004" @default.
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