FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103720967> ?p ?o ?g. }

• W2103720967 endingPage "715" @default.
• W2103720967 startingPage "704" @default.
• W2103720967 abstract "The molecular etiology of pelvic organ prolapse (POP) is complex and not well understood. We compared the expression/activity of extracellular matrix (ECM)-processing (procollagen I N-proteinase/ a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTS]-2,-3,-14) and ECM-degrading (matrix metalloproteinase [MMP]-1, -2, -7, -8, -9, -12) enzymes and their natural tissue inhibitors (tissue inhibitors of metalloproteinase [TIMP]-1,-2,-3,-4) in vaginal tissues from premenopausal women with advanced POP (POP-Q stage ≥ 3) and asymptomatic controls (POP-Q = 0). We sampled the anterior vaginal wall of 36 premenopausal women (17 patients with POP and 19 controls) undergoing total hysterectomy. Exclusion criteria include steroid therapy, malignancy, previous pelvic surgery, and connective tissue diseases. Total RNAs and proteins were quantified by real-time polymerase chain reaction, immunoblotting, and Luminex assay; MMPs activity was analyzed by zymography and tissue localization by immunohistochemistry. The MMP-2 gelatinase activity as well as expression of 58-kDa isoform of ADAMTS-2 was upregulated in patients with POP, irrespective of menstrual phase status, secretory or proliferative, when compared to controls (P < .05). The TIMP-1-4 gene and TIMP-1 protein expression were significantly (P < .05) reduced, whereas protein expression of MMP-12 (pro and active forms) was significantly increased in vaginal biopsies of patients with POP in the proliferative phase of the menstrual cycle compared to corresponding controls. Analyses of MMP-12, TIMP-1, and ADAMTS-2 tissue immunostaining indicate similar localization in the vaginal specimens from control and patients with POP. Expression of ECM-remodeling proteins is altered in the vagina of premenopausal patients with severe POP. We speculate that dysregulation of MMP/TIMP complexes and ADAMTS-2 proteins may cause connective tissue defects, which result in weakened vaginal wall support and POP development." @default.
• W2103720967 created "2016-06-24" @default.
• W2103720967 creator A5002660152 @default.
• W2103720967 creator A5003514008 @default.
• W2103720967 creator A5012668978 @default.
• W2103720967 creator A5032904180 @default.
• W2103720967 creator A5044473789 @default.
• W2103720967 date "2014-06-01" @default.
• W2103720967 modified "2023-10-17" @default.
• W2103720967 title "Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic Organ Prolapse" @default.
• W2103720967 cites W1572793678 @default.
• W2103720967 cites W1914982103 @default.
• W2103720967 cites W1963633579 @default.
• W2103720967 cites W1975693209 @default.
• W2103720967 cites W1983537781 @default.
• W2103720967 cites W1987825791 @default.
• W2103720967 cites W1992206336 @default.
• W2103720967 cites W2004584798 @default.
• W2103720967 cites W2004990490 @default.
• W2103720967 cites W2005051695 @default.
• W2103720967 cites W2033672654 @default.
• W2103720967 cites W2035690431 @default.
• W2103720967 cites W2036511155 @default.
• W2103720967 cites W2038473044 @default.
• W2103720967 cites W2047208025 @default.
• W2103720967 cites W2047750483 @default.
• W2103720967 cites W2071163881 @default.
• W2103720967 cites W2071359561 @default.
• W2103720967 cites W2075289132 @default.
• W2103720967 cites W2082330339 @default.
• W2103720967 cites W2087578685 @default.
• W2103720967 cites W2097785181 @default.
• W2103720967 cites W2106880616 @default.
• W2103720967 cites W2109191037 @default.
• W2103720967 cites W2114570899 @default.
• W2103720967 cites W2144582380 @default.
• W2103720967 cites W2147089345 @default.
• W2103720967 cites W2163766015 @default.
• W2103720967 cites W4241758452 @default.
• W2103720967 cites W4321429396 @default.
• W2103720967 doi "https://doi.org/10.1177/1933719113512529" @default.
• W2103720967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4016721" @default.
• W2103720967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24343133" @default.
• W2103720967 hasPublicationYear "2014" @default.
• W2103720967 type Work @default.
• W2103720967 sameAs 2103720967 @default.
• W2103720967 citedByCount "43" @default.
• W2103720967 countsByYear W21037209672016 @default.
• W2103720967 countsByYear W21037209672017 @default.
• W2103720967 countsByYear W21037209672018 @default.
• W2103720967 countsByYear W21037209672019 @default.
• W2103720967 countsByYear W21037209672020 @default.
• W2103720967 countsByYear W21037209672021 @default.
• W2103720967 countsByYear W21037209672022 @default.
• W2103720967 countsByYear W21037209672023 @default.
• W2103720967 crossrefType "journal-article" @default.
• W2103720967 hasAuthorship W2103720967A5002660152 @default.
• W2103720967 hasAuthorship W2103720967A5003514008 @default.
• W2103720967 hasAuthorship W2103720967A5012668978 @default.
• W2103720967 hasAuthorship W2103720967A5032904180 @default.
• W2103720967 hasAuthorship W2103720967A5044473789 @default.
• W2103720967 hasBestOaLocation W21037209672 @default.
• W2103720967 hasConcept C109523444 @default.
• W2103720967 hasConcept C126322002 @default.
• W2103720967 hasConcept C142724271 @default.
• W2103720967 hasConcept C16685009 @default.
• W2103720967 hasConcept C167814343 @default.
• W2103720967 hasConcept C177430391 @default.
• W2103720967 hasConcept C181199279 @default.
• W2103720967 hasConcept C189165786 @default.
• W2103720967 hasConcept C204232928 @default.
• W2103720967 hasConcept C2775965246 @default.
• W2103720967 hasConcept C2776224515 @default.
• W2103720967 hasConcept C2776747403 @default.
• W2103720967 hasConcept C2778394429 @default.
• W2103720967 hasConcept C4224716 @default.
• W2103720967 hasConcept C55493867 @default.
• W2103720967 hasConcept C55728118 @default.
• W2103720967 hasConcept C71924100 @default.
• W2103720967 hasConcept C86803240 @default.
• W2103720967 hasConcept C95444343 @default.
• W2103720967 hasConceptScore W2103720967C109523444 @default.
• W2103720967 hasConceptScore W2103720967C126322002 @default.
• W2103720967 hasConceptScore W2103720967C142724271 @default.
• W2103720967 hasConceptScore W2103720967C16685009 @default.
• W2103720967 hasConceptScore W2103720967C167814343 @default.
• W2103720967 hasConceptScore W2103720967C177430391 @default.
• W2103720967 hasConceptScore W2103720967C181199279 @default.
• W2103720967 hasConceptScore W2103720967C189165786 @default.
• W2103720967 hasConceptScore W2103720967C204232928 @default.
• W2103720967 hasConceptScore W2103720967C2775965246 @default.
• W2103720967 hasConceptScore W2103720967C2776224515 @default.
• W2103720967 hasConceptScore W2103720967C2776747403 @default.
• W2103720967 hasConceptScore W2103720967C2778394429 @default.
• W2103720967 hasConceptScore W2103720967C4224716 @default.
• W2103720967 hasConceptScore W2103720967C55493867 @default.
• W2103720967 hasConceptScore W2103720967C55728118 @default.
• W2103720967 hasConceptScore W2103720967C71924100 @default.

• next