Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103722175> ?p ?o ?g. }
- W2103722175 endingPage "1053" @default.
- W2103722175 startingPage "1043" @default.
- W2103722175 abstract "The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. We report here that silencing SMURF2 (SMAD specific E3 ubiquitin protein ligase 2) promoted EMT in HPDE6c7 normal pancreas cells and overexpression of SMURF2 inhibited TGF-β-mediated EMT in the cells. Subsequent studies showed that SMURF2 was downregulated in pancreatic cancer tissues and it promoted mesenchymal-epithelial transition (MET) in pancreatic cancer cells as well as its expression negatively associated with gemcitabine-resistance, but it did not alter cell viability, cell cycle and cell senescence. In addition, we demonstrated that miR‑15b degraded SMURF2 and its overexpression promoted EMT in pancreatic cancer, and its expression was associated with metastasis in the disease. Elucidating molecular mechanism of EMT in pancreatic cancer not only will help us to further understand the pathogenesis and progression of the disease, but also offers new targets for effective therapies." @default.
- W2103722175 created "2016-06-24" @default.
- W2103722175 creator A5065678914 @default.
- W2103722175 creator A5070729378 @default.
- W2103722175 creator A5072284526 @default.
- W2103722175 creator A5085039487 @default.
- W2103722175 creator A5089744573 @default.
- W2103722175 date "2015-07-09" @default.
- W2103722175 modified "2023-10-12" @default.
- W2103722175 title "miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer" @default.
- W2103722175 cites W1648301895 @default.
- W2103722175 cites W1760215417 @default.
- W2103722175 cites W1920303762 @default.
- W2103722175 cites W1958284284 @default.
- W2103722175 cites W1970265228 @default.
- W2103722175 cites W1971003402 @default.
- W2103722175 cites W1972316552 @default.
- W2103722175 cites W1972892962 @default.
- W2103722175 cites W1974650935 @default.
- W2103722175 cites W1977075884 @default.
- W2103722175 cites W1977798919 @default.
- W2103722175 cites W1979342940 @default.
- W2103722175 cites W1983148314 @default.
- W2103722175 cites W1985136204 @default.
- W2103722175 cites W1987473368 @default.
- W2103722175 cites W2000093333 @default.
- W2103722175 cites W2008955962 @default.
- W2103722175 cites W2016805904 @default.
- W2103722175 cites W2017905687 @default.
- W2103722175 cites W2020080445 @default.
- W2103722175 cites W2025647419 @default.
- W2103722175 cites W2038569449 @default.
- W2103722175 cites W2039748798 @default.
- W2103722175 cites W2043797012 @default.
- W2103722175 cites W2060315334 @default.
- W2103722175 cites W2066441178 @default.
- W2103722175 cites W2070777085 @default.
- W2103722175 cites W2075691222 @default.
- W2103722175 cites W2076583198 @default.
- W2103722175 cites W2076636899 @default.
- W2103722175 cites W2078818685 @default.
- W2103722175 cites W2081601075 @default.
- W2103722175 cites W2082055110 @default.
- W2103722175 cites W2100751052 @default.
- W2103722175 cites W2101121084 @default.
- W2103722175 cites W2112680319 @default.
- W2103722175 cites W2121455258 @default.
- W2103722175 cites W2129355962 @default.
- W2103722175 cites W2137280750 @default.
- W2103722175 cites W2138664009 @default.
- W2103722175 cites W2140551998 @default.
- W2103722175 cites W2158734599 @default.
- W2103722175 cites W2163958696 @default.
- W2103722175 cites W3023299375 @default.
- W2103722175 doi "https://doi.org/10.3892/ijo.2015.3076" @default.
- W2103722175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26166038" @default.
- W2103722175 hasPublicationYear "2015" @default.
- W2103722175 type Work @default.
- W2103722175 sameAs 2103722175 @default.
- W2103722175 citedByCount "49" @default.
- W2103722175 countsByYear W21037221752016 @default.
- W2103722175 countsByYear W21037221752017 @default.
- W2103722175 countsByYear W21037221752018 @default.
- W2103722175 countsByYear W21037221752019 @default.
- W2103722175 countsByYear W21037221752020 @default.
- W2103722175 countsByYear W21037221752021 @default.
- W2103722175 countsByYear W21037221752022 @default.
- W2103722175 countsByYear W21037221752023 @default.
- W2103722175 crossrefType "journal-article" @default.
- W2103722175 hasAuthorship W2103722175A5065678914 @default.
- W2103722175 hasAuthorship W2103722175A5070729378 @default.
- W2103722175 hasAuthorship W2103722175A5072284526 @default.
- W2103722175 hasAuthorship W2103722175A5085039487 @default.
- W2103722175 hasAuthorship W2103722175A5089744573 @default.
- W2103722175 hasBestOaLocation W21037221751 @default.
- W2103722175 hasConcept C104317684 @default.
- W2103722175 hasConcept C118131993 @default.
- W2103722175 hasConcept C119056186 @default.
- W2103722175 hasConcept C121608353 @default.
- W2103722175 hasConcept C134459356 @default.
- W2103722175 hasConcept C1491633281 @default.
- W2103722175 hasConcept C25602115 @default.
- W2103722175 hasConcept C2779013556 @default.
- W2103722175 hasConcept C2780210213 @default.
- W2103722175 hasConcept C2780258809 @default.
- W2103722175 hasConcept C2781018059 @default.
- W2103722175 hasConcept C2781080636 @default.
- W2103722175 hasConcept C29537977 @default.
- W2103722175 hasConcept C502942594 @default.
- W2103722175 hasConcept C54355233 @default.
- W2103722175 hasConcept C55493867 @default.
- W2103722175 hasConcept C76419328 @default.
- W2103722175 hasConcept C86803240 @default.
- W2103722175 hasConcept C95444343 @default.
- W2103722175 hasConcept C96232424 @default.
- W2103722175 hasConceptScore W2103722175C104317684 @default.
- W2103722175 hasConceptScore W2103722175C118131993 @default.
- W2103722175 hasConceptScore W2103722175C119056186 @default.