Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103722667> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2103722667 endingPage "85" @default.
- W2103722667 startingPage "85" @default.
- W2103722667 abstract "Background: Spinal zaprinast, phospodiesterase inhibitor, has been shown to have an antinociception through an increase of cGMP. The aim of this study was to examine the role of spinal adrenergic and cholinergic receptors on the antinociceptive action of intrathecal zaprinast. Methods: Rats were implanted with lumbar intrathecal catheters. After formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min. After observing the effect of intrathecal zaprinast, antagonism of intrathecal prazosin, yohimbine, atropine and mecamylamine for the effect of zaprinast were evaluated. Results: Intrathecal zaprinast produced a dose-dependent suppression of formalin-induced flinches in both phases of the formalin test. Intrathecal prazosin reversed the antinociception of zaprinast in phase 2, but not phase 1. Intrathecal yohimbine reversed the antinociception of zaprinast in both phases. Neither atropine nor mecamylamine reversed the antinocicetive action of zaprinast. Conclusions: Intrathecal zaprinast is against the nociceptive state evoked by formalin stimulus. Alpha 2 or alpha 1 adrenergic receptor, but not cholinergic receptors, may be related to the action of zaprinast in the spinal cord." @default.
- W2103722667 created "2016-06-24" @default.
- W2103722667 creator A5007862324 @default.
- W2103722667 creator A5010182962 @default.
- W2103722667 creator A5012454436 @default.
- W2103722667 creator A5024811015 @default.
- W2103722667 creator A5042968243 @default.
- W2103722667 creator A5045246955 @default.
- W2103722667 creator A5079083285 @default.
- W2103722667 date "2007-01-01" @default.
- W2103722667 modified "2023-10-16" @default.
- W2103722667 title "The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Intrathecal Zaprinast in the Formalin Test of Rats" @default.
- W2103722667 cites W1904153590 @default.
- W2103722667 cites W1963599817 @default.
- W2103722667 cites W1963778325 @default.
- W2103722667 cites W1964941501 @default.
- W2103722667 cites W1968547606 @default.
- W2103722667 cites W1980349142 @default.
- W2103722667 cites W1985078992 @default.
- W2103722667 cites W1990688335 @default.
- W2103722667 cites W2017935253 @default.
- W2103722667 cites W2027246592 @default.
- W2103722667 cites W2040725197 @default.
- W2103722667 cites W2045886062 @default.
- W2103722667 cites W2050714163 @default.
- W2103722667 cites W2050879963 @default.
- W2103722667 cites W2063680573 @default.
- W2103722667 cites W2088379827 @default.
- W2103722667 cites W2088992057 @default.
- W2103722667 cites W2093903384 @default.
- W2103722667 cites W2114055974 @default.
- W2103722667 cites W2166389885 @default.
- W2103722667 cites W2313326603 @default.
- W2103722667 cites W2322579009 @default.
- W2103722667 cites W2419049440 @default.
- W2103722667 cites W95567247 @default.
- W2103722667 doi "https://doi.org/10.4097/kjae.2007.53.1.85" @default.
- W2103722667 hasPublicationYear "2007" @default.
- W2103722667 type Work @default.
- W2103722667 sameAs 2103722667 @default.
- W2103722667 citedByCount "0" @default.
- W2103722667 crossrefType "journal-article" @default.
- W2103722667 hasAuthorship W2103722667A5007862324 @default.
- W2103722667 hasAuthorship W2103722667A5010182962 @default.
- W2103722667 hasAuthorship W2103722667A5012454436 @default.
- W2103722667 hasAuthorship W2103722667A5024811015 @default.
- W2103722667 hasAuthorship W2103722667A5042968243 @default.
- W2103722667 hasAuthorship W2103722667A5045246955 @default.
- W2103722667 hasAuthorship W2103722667A5079083285 @default.
- W2103722667 hasBestOaLocation W21037226671 @default.
- W2103722667 hasConcept C126322002 @default.
- W2103722667 hasConcept C15744967 @default.
- W2103722667 hasConcept C157820659 @default.
- W2103722667 hasConcept C158453852 @default.
- W2103722667 hasConcept C169760540 @default.
- W2103722667 hasConcept C170493617 @default.
- W2103722667 hasConcept C173803235 @default.
- W2103722667 hasConcept C22885893 @default.
- W2103722667 hasConcept C2776846068 @default.
- W2103722667 hasConcept C2778399450 @default.
- W2103722667 hasConcept C40465926 @default.
- W2103722667 hasConcept C42219234 @default.
- W2103722667 hasConcept C71924100 @default.
- W2103722667 hasConcept C98274493 @default.
- W2103722667 hasConceptScore W2103722667C126322002 @default.
- W2103722667 hasConceptScore W2103722667C15744967 @default.
- W2103722667 hasConceptScore W2103722667C157820659 @default.
- W2103722667 hasConceptScore W2103722667C158453852 @default.
- W2103722667 hasConceptScore W2103722667C169760540 @default.
- W2103722667 hasConceptScore W2103722667C170493617 @default.
- W2103722667 hasConceptScore W2103722667C173803235 @default.
- W2103722667 hasConceptScore W2103722667C22885893 @default.
- W2103722667 hasConceptScore W2103722667C2776846068 @default.
- W2103722667 hasConceptScore W2103722667C2778399450 @default.
- W2103722667 hasConceptScore W2103722667C40465926 @default.
- W2103722667 hasConceptScore W2103722667C42219234 @default.
- W2103722667 hasConceptScore W2103722667C71924100 @default.
- W2103722667 hasConceptScore W2103722667C98274493 @default.
- W2103722667 hasIssue "1" @default.
- W2103722667 hasLocation W21037226671 @default.
- W2103722667 hasOpenAccess W2103722667 @default.
- W2103722667 hasPrimaryLocation W21037226671 @default.
- W2103722667 hasRelatedWork W2010113461 @default.
- W2103722667 hasRelatedWork W2020320506 @default.
- W2103722667 hasRelatedWork W2027043399 @default.
- W2103722667 hasRelatedWork W2052453588 @default.
- W2103722667 hasRelatedWork W2063673475 @default.
- W2103722667 hasRelatedWork W2107393069 @default.
- W2103722667 hasRelatedWork W2145698717 @default.
- W2103722667 hasRelatedWork W2419392189 @default.
- W2103722667 hasRelatedWork W2423676178 @default.
- W2103722667 hasRelatedWork W2476001265 @default.
- W2103722667 hasVolume "53" @default.
- W2103722667 isParatext "false" @default.
- W2103722667 isRetracted "false" @default.
- W2103722667 magId "2103722667" @default.
- W2103722667 workType "article" @default.