FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103729667> ?p ?o ?g. }

• W2103729667 endingPage "49" @default.
• W2103729667 startingPage "43" @default.
• W2103729667 abstract "Clozapine is an atypical antipsychotic drug active on both positive and negative symptoms of schizophrenia which has a unique serotonergic and dopaminergic profile. Given the putative role of the medial prefrontal cortex (mPFC) in negative symptoms of schizophrenia, the aim of this study was to assess the effects of clozapine on the dopamine- and serotonin-responsive neurons in that particular brain structure. D1 and D2 agonists (SKF 38393 and quinpirole) as well as 5-HT2 and 5-HT3 agonists (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, DOI, and phenylbiguanide) were applied by microiontophoresis alone and concurrently with clozapine while recording extracellularly mPFC neurons. Dopamine ejections inhibited firing activity while D1 and D2 agonists were ineffective. Clozapine did not change basal firing by itself, but was able to suppress the inhibition produced by dopamine and by the 5-HT2/5-HT3 receptor agonists. It is concluded that clozapine at the mPFC level exerts a complex modulatory activity on dopamine receptors, that is directly at the dopaminergic receptors and through 5-HT receptors on the same neurons." @default.
• W2103729667 created "2016-06-24" @default.
• W2103729667 creator A5010580951 @default.
• W2103729667 creator A5022015648 @default.
• W2103729667 date "1999-12-01" @default.
• W2103729667 modified "2023-10-04" @default.
• W2103729667 title "Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study" @default.
• W2103729667 cites W1964103066 @default.
• W2103729667 cites W1967466077 @default.
• W2103729667 cites W1982539986 @default.
• W2103729667 cites W1983108567 @default.
• W2103729667 cites W1997635941 @default.
• W2103729667 cites W2009821818 @default.
• W2103729667 cites W2015672650 @default.
• W2103729667 cites W2021093002 @default.
• W2103729667 cites W2026395566 @default.
• W2103729667 cites W2032980276 @default.
• W2103729667 cites W2034957480 @default.
• W2103729667 cites W2039646168 @default.
• W2103729667 cites W2041487100 @default.
• W2103729667 cites W2041601179 @default.
• W2103729667 cites W2043393596 @default.
• W2103729667 cites W2048654901 @default.
• W2103729667 cites W2057765374 @default.
• W2103729667 cites W2059230444 @default.
• W2103729667 cites W2090006102 @default.
• W2103729667 cites W2107964407 @default.
• W2103729667 cites W2114507789 @default.
• W2103729667 cites W4239438238 @default.
• W2103729667 doi "https://doi.org/10.1016/s0924-977x(99)00055-3" @default.
• W2103729667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10647096" @default.
• W2103729667 hasPublicationYear "1999" @default.
• W2103729667 type Work @default.
• W2103729667 sameAs 2103729667 @default.
• W2103729667 citedByCount "22" @default.
• W2103729667 countsByYear W21037296672012 @default.
• W2103729667 countsByYear W21037296672014 @default.
• W2103729667 countsByYear W21037296672015 @default.
• W2103729667 countsByYear W21037296672016 @default.
• W2103729667 countsByYear W21037296672018 @default.
• W2103729667 countsByYear W21037296672019 @default.
• W2103729667 countsByYear W21037296672021 @default.
• W2103729667 crossrefType "journal-article" @default.
• W2103729667 hasAuthorship W2103729667A5010580951 @default.
• W2103729667 hasAuthorship W2103729667A5022015648 @default.
• W2103729667 hasConcept C118552586 @default.
• W2103729667 hasConcept C137183658 @default.
• W2103729667 hasConcept C15744967 @default.
• W2103729667 hasConcept C169760540 @default.
• W2103729667 hasConcept C169900460 @default.
• W2103729667 hasConcept C185592680 @default.
• W2103729667 hasConcept C2776412080 @default.
• W2103729667 hasConcept C2776921671 @default.
• W2103729667 hasConcept C2778296116 @default.
• W2103729667 hasConcept C2780494398 @default.
• W2103729667 hasConcept C2780864610 @default.
• W2103729667 hasConcept C2780948874 @default.
• W2103729667 hasConcept C2781195155 @default.
• W2103729667 hasConcept C44208683 @default.
• W2103729667 hasConcept C513476851 @default.
• W2103729667 hasConcept C71924100 @default.
• W2103729667 hasConcept C98274493 @default.
• W2103729667 hasConceptScore W2103729667C118552586 @default.
• W2103729667 hasConceptScore W2103729667C137183658 @default.
• W2103729667 hasConceptScore W2103729667C15744967 @default.
• W2103729667 hasConceptScore W2103729667C169760540 @default.
• W2103729667 hasConceptScore W2103729667C169900460 @default.
• W2103729667 hasConceptScore W2103729667C185592680 @default.
• W2103729667 hasConceptScore W2103729667C2776412080 @default.
• W2103729667 hasConceptScore W2103729667C2776921671 @default.
• W2103729667 hasConceptScore W2103729667C2778296116 @default.
• W2103729667 hasConceptScore W2103729667C2780494398 @default.
• W2103729667 hasConceptScore W2103729667C2780864610 @default.
• W2103729667 hasConceptScore W2103729667C2780948874 @default.
• W2103729667 hasConceptScore W2103729667C2781195155 @default.
• W2103729667 hasConceptScore W2103729667C44208683 @default.
• W2103729667 hasConceptScore W2103729667C513476851 @default.
• W2103729667 hasConceptScore W2103729667C71924100 @default.
• W2103729667 hasConceptScore W2103729667C98274493 @default.
• W2103729667 hasIssue "1" @default.
• W2103729667 hasLocation W21037296671 @default.
• W2103729667 hasLocation W21037296672 @default.
• W2103729667 hasOpenAccess W2103729667 @default.
• W2103729667 hasPrimaryLocation W21037296671 @default.
• W2103729667 hasRelatedWork W1972796309 @default.
• W2103729667 hasRelatedWork W1983138582 @default.
• W2103729667 hasRelatedWork W2008234279 @default.
• W2103729667 hasRelatedWork W2030582734 @default.
• W2103729667 hasRelatedWork W2103729667 @default.
• W2103729667 hasRelatedWork W2114984406 @default.
• W2103729667 hasRelatedWork W2158320199 @default.
• W2103729667 hasRelatedWork W2159377548 @default.
• W2103729667 hasRelatedWork W3132363716 @default.
• W2103729667 hasRelatedWork W4293586768 @default.
• W2103729667 hasVolume "10" @default.
• W2103729667 isParatext "false" @default.
• W2103729667 isRetracted "false" @default.
• W2103729667 magId "2103729667" @default.

• next