Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103734115> ?p ?o ?g. }
- W2103734115 endingPage "234" @default.
- W2103734115 startingPage "225" @default.
- W2103734115 abstract "Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Oxidative stress is an important mechanism in the pathogenesis of this disease. The oxidant/ antioxidant imbalance occurring in smokers and patients with COPD is well established. Thus, therapeutic strategies targeting oxidative stress with pharmacological antioxidant agents or boosting the endogenous levels of antioxidants is likely to be beneficial as an adjunctive tool in the treatment of COPD patients. Thiol compounts such as N-acetyl-L-cysteine (NAC), carbocysteine, erdosteine, and fudosteine have been extensively studied. Although some results remain controversial, NAC and carbocysteine seem to have beneficial effect in patients not receiving inhaled corticosteroids who suffer from frequent exacerbations. In addition, other antioxidants like superoxide dismutase (SOD) mimetics and nuclear factor-erythroid 2 related factor 2 (Nrf2) are shown to decrease markers of oxidative stress in patients with emphysema, while others like glutathione peroxidase (GPx) mimetics and NO synthase (iNOS) can prevent both inflammation and oxidative stress in clinical trials in vivo (or in mouse models). In this article we review the effectiveness of various antioxidant factors in COPD and their potential beneficial effect in the treatment of the disease. Keywords: COPD, antioxidants, oxidative stress, N-acetylcysteine" @default.
- W2103734115 created "2016-06-24" @default.
- W2103734115 creator A5025428574 @default.
- W2103734115 creator A5046774961 @default.
- W2103734115 creator A5068927620 @default.
- W2103734115 creator A5069455623 @default.
- W2103734115 date "2013-01-01" @default.
- W2103734115 modified "2023-09-27" @default.
- W2103734115 title "Antioxidants and Mucolytics in COPD Management: When (if ever) and in Whom?" @default.
- W2103734115 cites W1480003811 @default.
- W2103734115 cites W1494726887 @default.
- W2103734115 cites W1537234007 @default.
- W2103734115 cites W1586791826 @default.
- W2103734115 cites W1798051272 @default.
- W2103734115 cites W1850923226 @default.
- W2103734115 cites W1909558445 @default.
- W2103734115 cites W1933984380 @default.
- W2103734115 cites W1941150430 @default.
- W2103734115 cites W1965810224 @default.
- W2103734115 cites W1973808559 @default.
- W2103734115 cites W1977403821 @default.
- W2103734115 cites W1977818019 @default.
- W2103734115 cites W1978444750 @default.
- W2103734115 cites W1978892575 @default.
- W2103734115 cites W1979345635 @default.
- W2103734115 cites W1982153589 @default.
- W2103734115 cites W1983638360 @default.
- W2103734115 cites W1983754228 @default.
- W2103734115 cites W1984574963 @default.
- W2103734115 cites W1985628471 @default.
- W2103734115 cites W1989494330 @default.
- W2103734115 cites W1989935661 @default.
- W2103734115 cites W1996612890 @default.
- W2103734115 cites W1999992979 @default.
- W2103734115 cites W2001177742 @default.
- W2103734115 cites W2001803608 @default.
- W2103734115 cites W2002592591 @default.
- W2103734115 cites W2007664092 @default.
- W2103734115 cites W2010592540 @default.
- W2103734115 cites W2016073678 @default.
- W2103734115 cites W2020682518 @default.
- W2103734115 cites W2022495082 @default.
- W2103734115 cites W2025222765 @default.
- W2103734115 cites W2025855341 @default.
- W2103734115 cites W2032901403 @default.
- W2103734115 cites W2034237477 @default.
- W2103734115 cites W2034751609 @default.
- W2103734115 cites W2041914412 @default.
- W2103734115 cites W2042450062 @default.
- W2103734115 cites W2043916189 @default.
- W2103734115 cites W2045749557 @default.
- W2103734115 cites W2049706884 @default.
- W2103734115 cites W2051513032 @default.
- W2103734115 cites W2053517795 @default.
- W2103734115 cites W2055148540 @default.
- W2103734115 cites W2055657360 @default.
- W2103734115 cites W2056613592 @default.
- W2103734115 cites W2056910995 @default.
- W2103734115 cites W2057395321 @default.
- W2103734115 cites W2057759589 @default.
- W2103734115 cites W2064181791 @default.
- W2103734115 cites W2064583844 @default.
- W2103734115 cites W2065976679 @default.
- W2103734115 cites W2083756305 @default.
- W2103734115 cites W2083860566 @default.
- W2103734115 cites W2086410495 @default.
- W2103734115 cites W2090790151 @default.
- W2103734115 cites W2092829657 @default.
- W2103734115 cites W2098115046 @default.
- W2103734115 cites W2103678472 @default.
- W2103734115 cites W2103916161 @default.
- W2103734115 cites W2104316143 @default.
- W2103734115 cites W2104590780 @default.
- W2103734115 cites W2105064034 @default.
- W2103734115 cites W2107021471 @default.
- W2103734115 cites W2107083830 @default.
- W2103734115 cites W2108692362 @default.
- W2103734115 cites W2115327946 @default.
- W2103734115 cites W2117465918 @default.
- W2103734115 cites W2118525756 @default.
- W2103734115 cites W2120290710 @default.
- W2103734115 cites W2123597424 @default.
- W2103734115 cites W2124631075 @default.
- W2103734115 cites W2125477645 @default.
- W2103734115 cites W2126722839 @default.
- W2103734115 cites W2130462780 @default.
- W2103734115 cites W2130937986 @default.
- W2103734115 cites W2132957248 @default.
- W2103734115 cites W2133514480 @default.
- W2103734115 cites W2134498505 @default.
- W2103734115 cites W2135682290 @default.
- W2103734115 cites W2135866362 @default.
- W2103734115 cites W2136166568 @default.
- W2103734115 cites W2138120017 @default.
- W2103734115 cites W2138641064 @default.
- W2103734115 cites W2139909190 @default.
- W2103734115 cites W2140264378 @default.
- W2103734115 cites W2140905994 @default.