Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103744172> ?p ?o ?g. }
- W2103744172 endingPage "S92" @default.
- W2103744172 startingPage "S82" @default.
- W2103744172 abstract "Atypical parkinson disorders (APD) are rapidly progressive neurodegenerative diseases with a variable clinical presentation that may even mimic Parkinson's disease. Multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are commonly summarized under this umbrella term. Significant developments in research have expanded knowledge and have broadened available symptomatic treatments, particularly for the treatment of neurogenic orthostatic hypotension. Nonetheless, symptomatic support still remains limited in all of these disorders. Currently, there exists no effective treatment to delay disease progression and disease-modifying trials have failed to provide coherent and convincing results. Recent trials of rasagiline (in MSA), rifampicin (in MSA), tideglusib (in PSP) and davunetide (in PSP) reported negative results. Nevertheless, large cohorts of patients were recruited for interventional studies in the last few years which improved our understanding of trial methodology in APDs immensely. In addition, remarkable progress in basic research has been reported recently and will provide a solid foundation for future therapeutic trials. In this review, we will summarize published randomized, placebo-controlled clinical trials (RCTs) in APDs. Additionally, the design of ongoing and unpublished interventions will be presented." @default.
- W2103744172 created "2016-06-24" @default.
- W2103744172 creator A5041968375 @default.
- W2103744172 creator A5054318770 @default.
- W2103744172 creator A5064715109 @default.
- W2103744172 date "2016-01-01" @default.
- W2103744172 modified "2023-10-18" @default.
- W2103744172 title "Interventional trials in atypical parkinsonism" @default.
- W2103744172 cites W1527750088 @default.
- W2103744172 cites W1558658318 @default.
- W2103744172 cites W1982852824 @default.
- W2103744172 cites W1983997527 @default.
- W2103744172 cites W1986045469 @default.
- W2103744172 cites W1989649721 @default.
- W2103744172 cites W1991849900 @default.
- W2103744172 cites W2014594848 @default.
- W2103744172 cites W2017997997 @default.
- W2103744172 cites W2018615984 @default.
- W2103744172 cites W2028947945 @default.
- W2103744172 cites W2029445782 @default.
- W2103744172 cites W2040566836 @default.
- W2103744172 cites W2048764982 @default.
- W2103744172 cites W2049327045 @default.
- W2103744172 cites W2051693254 @default.
- W2103744172 cites W2052197301 @default.
- W2103744172 cites W2056590363 @default.
- W2103744172 cites W2071599778 @default.
- W2103744172 cites W2077431087 @default.
- W2103744172 cites W2080261002 @default.
- W2103744172 cites W2098004842 @default.
- W2103744172 cites W2105259937 @default.
- W2103744172 cites W2112512153 @default.
- W2103744172 cites W2114832183 @default.
- W2103744172 cites W2119748685 @default.
- W2103744172 cites W2121832545 @default.
- W2103744172 cites W2122211082 @default.
- W2103744172 cites W2125747694 @default.
- W2103744172 cites W2127136136 @default.
- W2103744172 cites W2129669150 @default.
- W2103744172 cites W2131110602 @default.
- W2103744172 cites W2141041456 @default.
- W2103744172 cites W2153988998 @default.
- W2103744172 cites W2154560807 @default.
- W2103744172 cites W2158832061 @default.
- W2103744172 cites W2161016232 @default.
- W2103744172 cites W2166557928 @default.
- W2103744172 cites W2168396089 @default.
- W2103744172 cites W2171749332 @default.
- W2103744172 cites W4294549596 @default.
- W2103744172 doi "https://doi.org/10.1016/j.parkreldis.2015.09.038" @default.
- W2103744172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26421389" @default.
- W2103744172 hasPublicationYear "2016" @default.
- W2103744172 type Work @default.
- W2103744172 sameAs 2103744172 @default.
- W2103744172 citedByCount "19" @default.
- W2103744172 countsByYear W21037441722016 @default.
- W2103744172 countsByYear W21037441722017 @default.
- W2103744172 countsByYear W21037441722018 @default.
- W2103744172 countsByYear W21037441722019 @default.
- W2103744172 countsByYear W21037441722020 @default.
- W2103744172 countsByYear W21037441722021 @default.
- W2103744172 countsByYear W21037441722022 @default.
- W2103744172 countsByYear W21037441722023 @default.
- W2103744172 crossrefType "journal-article" @default.
- W2103744172 hasAuthorship W2103744172A5041968375 @default.
- W2103744172 hasAuthorship W2103744172A5054318770 @default.
- W2103744172 hasAuthorship W2103744172A5064715109 @default.
- W2103744172 hasConcept C142724271 @default.
- W2103744172 hasConcept C168563851 @default.
- W2103744172 hasConcept C177713679 @default.
- W2103744172 hasConcept C1862650 @default.
- W2103744172 hasConcept C2776477761 @default.
- W2103744172 hasConcept C2776525014 @default.
- W2103744172 hasConcept C2776936178 @default.
- W2103744172 hasConcept C2779134260 @default.
- W2103744172 hasConcept C2779734285 @default.
- W2103744172 hasConcept C2781249495 @default.
- W2103744172 hasConcept C535046627 @default.
- W2103744172 hasConcept C71924100 @default.
- W2103744172 hasConceptScore W2103744172C142724271 @default.
- W2103744172 hasConceptScore W2103744172C168563851 @default.
- W2103744172 hasConceptScore W2103744172C177713679 @default.
- W2103744172 hasConceptScore W2103744172C1862650 @default.
- W2103744172 hasConceptScore W2103744172C2776477761 @default.
- W2103744172 hasConceptScore W2103744172C2776525014 @default.
- W2103744172 hasConceptScore W2103744172C2776936178 @default.
- W2103744172 hasConceptScore W2103744172C2779134260 @default.
- W2103744172 hasConceptScore W2103744172C2779734285 @default.
- W2103744172 hasConceptScore W2103744172C2781249495 @default.
- W2103744172 hasConceptScore W2103744172C535046627 @default.
- W2103744172 hasConceptScore W2103744172C71924100 @default.
- W2103744172 hasLocation W21037441721 @default.
- W2103744172 hasLocation W21037441722 @default.
- W2103744172 hasOpenAccess W2103744172 @default.
- W2103744172 hasPrimaryLocation W21037441721 @default.
- W2103744172 hasRelatedWork W124854678 @default.
- W2103744172 hasRelatedWork W1972317130 @default.
- W2103744172 hasRelatedWork W1972577646 @default.