Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103753562> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2103753562 endingPage "956" @default.
- W2103753562 startingPage "951" @default.
- W2103753562 abstract "Depolarizing cardioplegia is the most common method for myocardial preservation in cardiac operations. However, depolarizing cardioplegia causes depolarization of the membrane potential by extracellular hyperkalemia, resulting in depletion of energy stores and calcium overload. This study examined the hypothesis that non-depolarizing cardioplegia would provide superior protection compared with depolarizing cardioplegia.In an isolated rat heart Langendorff model, hearts were perfused for 10 min with St. Thomas' Hospital cardioplegic solution (Group I: n=20), St. Thomas' Hospital cardioplegic solution+Lidocaine 1 mM (Group II: n=20) or non-depolarizing cardioplegia (Group III: n=20). The hearts then were subjected to 60 min of normothermic global ischemia, after which they were perfused with Krebs-Henseleit buffer at 37 degrees C for 30 min. The percent recovery of functional data, myocardial cyclic AMP contents, and myocardial cyclic GMP contents were recorded at each time point (base, after the administration of cardioplegia, after global ischemia, and after 30 min of reperfusion). Ca(2+)-ATPase in sarcoplasmic reticulum was measured at pre-ischemia and 30 min of reperfusion.The percent recovery of developed pressure and +/-dp/dt were significantly higher in Group III than in other groups. Myocardial cyclic AMP and GMP contents were elevated after reperfusion in all groups. However, in Group III, myocardial cyclic AMP contents after 30 min of reperfusion were significantly higher than in other groups (Group III: 14.7+/-1.6 vs. Group I: 8.7+/-1.0, Group II: 8.3+/-0.2 pmol/mg dry weight, P=0.05) but not cGMP. The sarcoplasmic reticulum Ca(2+)-ATPase activities at 30 min of reperfusion significantly increased in Group III compared with Groups II and I (Group III: 70.3+/-3.6 vs. Group I: 46.8+/-3.4, Group II: 53.9+/-6.1 micromol Pi/mg per h, P=0.025 and P=0.030).Non-depolarizing cardioplegia induced the activity of Ca(2+)-ATPase in sarcoplasmic reticulum after reperfusion. The activity would be increased by the cyclic AMP pathway. These findings suggested that non-depolarizing cardioplegia prevented calcium overload after reperfusion, especially decreased cytosolic calcium during the diastolic phase." @default.
- W2103753562 created "2016-06-24" @default.
- W2103753562 creator A5027394112 @default.
- W2103753562 date "2002-12-01" @default.
- W2103753562 modified "2023-09-30" @default.
- W2103753562 title "Non-depolarizing cardioplegia activates Ca2+-ATPase in sarcoplasmic reticulum after reperfusion" @default.
- W2103753562 cites W176044681 @default.
- W2103753562 cites W1965636847 @default.
- W2103753562 cites W1967132920 @default.
- W2103753562 cites W1968715318 @default.
- W2103753562 cites W1971806097 @default.
- W2103753562 cites W1977234303 @default.
- W2103753562 cites W1988432501 @default.
- W2103753562 cites W1990194240 @default.
- W2103753562 cites W2012543515 @default.
- W2103753562 cites W2013071117 @default.
- W2103753562 cites W2025692407 @default.
- W2103753562 cites W2030858573 @default.
- W2103753562 cites W2030979507 @default.
- W2103753562 cites W2030989730 @default.
- W2103753562 cites W2031896725 @default.
- W2103753562 cites W2032156621 @default.
- W2103753562 cites W2055055427 @default.
- W2103753562 cites W2075154281 @default.
- W2103753562 cites W2082539152 @default.
- W2103753562 cites W2138152730 @default.
- W2103753562 cites W2156976597 @default.
- W2103753562 cites W237068763 @default.
- W2103753562 cites W2410288775 @default.
- W2103753562 cites W2416563191 @default.
- W2103753562 doi "https://doi.org/10.1016/s1010-7940(02)00582-1" @default.
- W2103753562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12467819" @default.
- W2103753562 hasPublicationYear "2002" @default.
- W2103753562 type Work @default.
- W2103753562 sameAs 2103753562 @default.
- W2103753562 citedByCount "13" @default.
- W2103753562 countsByYear W21037535622012 @default.
- W2103753562 countsByYear W21037535622013 @default.
- W2103753562 countsByYear W21037535622015 @default.
- W2103753562 countsByYear W21037535622016 @default.
- W2103753562 countsByYear W21037535622017 @default.
- W2103753562 countsByYear W21037535622020 @default.
- W2103753562 countsByYear W21037535622021 @default.
- W2103753562 crossrefType "journal-article" @default.
- W2103753562 hasAuthorship W2103753562A5027394112 @default.
- W2103753562 hasBestOaLocation W21037535621 @default.
- W2103753562 hasConcept C126322002 @default.
- W2103753562 hasConcept C158617107 @default.
- W2103753562 hasConcept C164705383 @default.
- W2103753562 hasConcept C185592680 @default.
- W2103753562 hasConcept C2780243291 @default.
- W2103753562 hasConcept C4141045 @default.
- W2103753562 hasConcept C42219234 @default.
- W2103753562 hasConcept C519063684 @default.
- W2103753562 hasConcept C541997718 @default.
- W2103753562 hasConcept C55493867 @default.
- W2103753562 hasConcept C71924100 @default.
- W2103753562 hasConceptScore W2103753562C126322002 @default.
- W2103753562 hasConceptScore W2103753562C158617107 @default.
- W2103753562 hasConceptScore W2103753562C164705383 @default.
- W2103753562 hasConceptScore W2103753562C185592680 @default.
- W2103753562 hasConceptScore W2103753562C2780243291 @default.
- W2103753562 hasConceptScore W2103753562C4141045 @default.
- W2103753562 hasConceptScore W2103753562C42219234 @default.
- W2103753562 hasConceptScore W2103753562C519063684 @default.
- W2103753562 hasConceptScore W2103753562C541997718 @default.
- W2103753562 hasConceptScore W2103753562C55493867 @default.
- W2103753562 hasConceptScore W2103753562C71924100 @default.
- W2103753562 hasIssue "6" @default.
- W2103753562 hasLocation W21037535621 @default.
- W2103753562 hasLocation W21037535622 @default.
- W2103753562 hasOpenAccess W2103753562 @default.
- W2103753562 hasPrimaryLocation W21037535621 @default.
- W2103753562 hasRelatedWork W1531601525 @default.
- W2103753562 hasRelatedWork W1571195528 @default.
- W2103753562 hasRelatedWork W1985391996 @default.
- W2103753562 hasRelatedWork W2054656053 @default.
- W2103753562 hasRelatedWork W2063784476 @default.
- W2103753562 hasRelatedWork W2748952813 @default.
- W2103753562 hasRelatedWork W2899084033 @default.
- W2103753562 hasRelatedWork W2948807893 @default.
- W2103753562 hasRelatedWork W4245370611 @default.
- W2103753562 hasRelatedWork W2778153218 @default.
- W2103753562 hasVolume "22" @default.
- W2103753562 isParatext "false" @default.
- W2103753562 isRetracted "false" @default.
- W2103753562 magId "2103753562" @default.
- W2103753562 workType "article" @default.