FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103754299> ?p ?o ?g. }

• W2103754299 abstract "WHO estimates that 80% of mortality due to malaria occurs among infants and young children. Though it has long been established that malaria disproportionately affects children under age five, our understanding of the underlying biological mechanisms for this distribution remains incomplete. Many studies use age as an indicator of exposure, but age may affect malaria burden independently of previous exposure. Not only does the severity of malaria infection change with age, but the clinical manifestation of disease does as well: younger children are more likely to suffer severe anaemia, while older children are more likely to develop cerebral malaria. Intensity of transmission and acquired immunity are important determinants of this age variation, but age differences remain consistent over varying transmission levels. Thus, age differences in clinical presentation may involve inherent age-related factors as well as still-undiscovered facets of acquired immunity, perhaps including the rates at which relevant aspects of immunity are acquired. The concept of allometry - the relative growth of a part in relation to that of an entire organism or to a standard - has not previously been applied in the context of malaria infection. However, because malaria affects a number of organs and cells, including the liver, red blood cells, white blood cells, and spleen, which may intrinsically develop at rates partly independent of each other and of a child's overall size, developmental allometry may influence the course and consequences of malaria infection. Here, scattered items of evidence have been collected from a variety of disciplines, aiming to suggest possible research paths for investigating exposure-independent age differences affecting clinical outcomes of malaria infection." @default.
• W2103754299 created "2016-06-24" @default.
• W2103754299 creator A5017348677 @default.
• W2103754299 creator A5019044219 @default.
• W2103754299 creator A5059764275 @default.
• W2103754299 creator A5061240538 @default.
• W2103754299 date "2012-03-06" @default.
• W2103754299 modified "2023-10-16" @default.
• W2103754299 title "Developmental allometry and paediatric malaria" @default.
• W2103754299 cites W1540506247 @default.
• W2103754299 cites W1563093902 @default.
• W2103754299 cites W1624420511 @default.
• W2103754299 cites W1674394713 @default.
• W2103754299 cites W1682758370 @default.
• W2103754299 cites W189869399 @default.
• W2103754299 cites W1955660739 @default.
• W2103754299 cites W1964629907 @default.
• W2103754299 cites W1967449698 @default.
• W2103754299 cites W1970564042 @default.
• W2103754299 cites W1970636319 @default.
• W2103754299 cites W1974074965 @default.
• W2103754299 cites W1975133087 @default.
• W2103754299 cites W1975721615 @default.
• W2103754299 cites W1977535665 @default.
• W2103754299 cites W1979307901 @default.
• W2103754299 cites W1981160000 @default.
• W2103754299 cites W1986017621 @default.
• W2103754299 cites W1991084866 @default.
• W2103754299 cites W2000552640 @default.
• W2103754299 cites W2000902397 @default.
• W2103754299 cites W2002678874 @default.
• W2103754299 cites W2003472864 @default.
• W2103754299 cites W2003900447 @default.
• W2103754299 cites W2005470158 @default.
• W2103754299 cites W2011290533 @default.
• W2103754299 cites W2013133736 @default.
• W2103754299 cites W2016827757 @default.
• W2103754299 cites W2017333123 @default.
• W2103754299 cites W2024179545 @default.
• W2103754299 cites W2026375505 @default.
• W2103754299 cites W2026784762 @default.
• W2103754299 cites W2026816588 @default.
• W2103754299 cites W2030452111 @default.
• W2103754299 cites W2030698557 @default.
• W2103754299 cites W2031927049 @default.
• W2103754299 cites W2033459829 @default.
• W2103754299 cites W2036127369 @default.
• W2103754299 cites W2043550930 @default.
• W2103754299 cites W2044125091 @default.
• W2103754299 cites W2044150535 @default.
• W2103754299 cites W2044596656 @default.
• W2103754299 cites W2045755019 @default.
• W2103754299 cites W2046829645 @default.
• W2103754299 cites W2046894314 @default.
• W2103754299 cites W2048368768 @default.
• W2103754299 cites W2050744850 @default.
• W2103754299 cites W2052226782 @default.
• W2103754299 cites W2054199384 @default.
• W2103754299 cites W2057058998 @default.
• W2103754299 cites W2062396541 @default.
• W2103754299 cites W2071289820 @default.
• W2103754299 cites W2071883091 @default.
• W2103754299 cites W2073616642 @default.
• W2103754299 cites W2074413337 @default.
• W2103754299 cites W2084823740 @default.
• W2103754299 cites W2087189871 @default.
• W2103754299 cites W2087730095 @default.
• W2103754299 cites W2090613637 @default.
• W2103754299 cites W2092672386 @default.
• W2103754299 cites W2096468951 @default.
• W2103754299 cites W2096584806 @default.
• W2103754299 cites W2097933658 @default.
• W2103754299 cites W2099353457 @default.
• W2103754299 cites W2102374235 @default.
• W2103754299 cites W2105136979 @default.
• W2103754299 cites W2106620506 @default.
• W2103754299 cites W2108488524 @default.
• W2103754299 cites W2110742166 @default.
• W2103754299 cites W2112162063 @default.
• W2103754299 cites W2112729981 @default.
• W2103754299 cites W2112866009 @default.
• W2103754299 cites W2113251371 @default.
• W2103754299 cites W2113913859 @default.
• W2103754299 cites W2115211402 @default.
• W2103754299 cites W2115786726 @default.
• W2103754299 cites W2116270585 @default.
• W2103754299 cites W2118493661 @default.
• W2103754299 cites W2120276324 @default.
• W2103754299 cites W2121416096 @default.
• W2103754299 cites W2121437137 @default.
• W2103754299 cites W2123061620 @default.
• W2103754299 cites W2124850308 @default.
• W2103754299 cites W2126576666 @default.
• W2103754299 cites W2129124269 @default.
• W2103754299 cites W2131829058 @default.
• W2103754299 cites W2134164686 @default.
• W2103754299 cites W2135490630 @default.
• W2103754299 cites W2140022778 @default.
• W2103754299 cites W2142879334 @default.
• W2103754299 cites W2145743834 @default.

• next